A comparison of the apparent risks of childhood leukaemia from parental exposure to radiation in the six months prior to conception in the Sellafield workforce and the Japanese bomb survivors

The cases of childhood leukaemia found among children of the Sellafield workforce and those observed in the offspring of the Japanese bomb survivors are analysed using both exponential and linear forms of a relative risk model and employing dose estimates for the period six months pre-conception. The leukaemia relative risk coefficients for paternal (whole-body) exposure in this pre-conception period for children of Sellafield workers are found to be statistically incompatible with the (gonadal dose) coefficients applying to the offspring of the bomb survivors born in the period May 1946 to December 1946, i.e. born 9 to 16 months after the bombings. The incompatibility does not depend on whether the risks in the Japanese children are assumed to be a function simply of paternal gonadal dose or of combined paternal and maternal gonadal dose. This finding is also relatively robust to dosimetric uncertainties in the group of Sellafield fathers and to the addition of extra cases in the offspring of parents in the highest dose groups of both data sets.

[1]  F. Alexander,et al.  Community lifestyle characteristics and risk of acute lymphoblastic leukaemia in children , 1990, The Lancet.

[2]  A. J. Warner,et al.  Leukaemia risk and plutonium , 1990, Nature.

[3]  L. Kinlen,et al.  Evidence from population mixing in British New Towns 1946-85 of an infective basis for childhood leukaemia , 1990, The Lancet.

[4]  M. Little.  A comparison between the risks of childhood leukaemia from parental exposure to radiation in the Sellafield workforce and those displayed among the Japanese bomb survivors , 1990 .

[5]  D. Pierce,et al.  Allowing for random errors in radiation dose estimates for the atomic bomb survivor data. , 1990, Radiation research.

[6]  S. Wolff.  Child leukaemia — curies or cars? , 1990, Nature.

[7]  Y. Yoshimoto.  Cancer Risk Among Children of Atomic Bomb Survivors: A Review of RERF Epidemiologic Studies , 1990 .

[8]  Y. Yoshimoto.  Cancer risk among children of atomic bomb survivors. A review of RERF epidemiologic studies. Radiation Effects Research Foundation. , 1990 .

[9]  S. Abrahamson.  Childhood leukemia at Sellafield. , 1990, Radiation research.

[10]  W. Müller.  Transmission of leukaemia , 1990, Nature.

[11]  H. Kato,et al.  Malignant tumors during the first 2 decades of life in the offspring of atomic bomb survivors. , 1990, American journal of human genetics.

[12]  W. Schull,et al.  The children of parents exposed to atomic bombs: estimates of the genetic doubling dose of radiation for humans. , 1990, American journal of human genetics.

[13]  Mel Greaves.  The Sellafield childhood leukemia cluster: are germline mutations responsible? , 1990, Leukemia.

[14]  H. Evans,et al.  Leukaemia and radiation , 1990, Nature.

[15]  W. Schull,et al.  Congenital malformations, stillbirths, and early mortality among the children of atomic bomb survivors: a reanalysis. , 1990, Radiation research.

[16]  E. Knox,et al.  Leukaemia and lymphoma among young people near Sellafield , 1990 .

[17]  J. Shepherd,et al.  Trauma services in a district general hospital , 1990, British medical journal.

[18]  Martin J Gardner,et al.  Leukaemia and lymphoma among young people near Sellafield , 1990 .

[19]  M. Gardner,et al.  Methods and basic data of case-control study of leukaemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria. , 1990, BMJ.

[20]  V. Beral,et al.  Leukaemia and nuclear installations. , 1990, BMJ.

[21]  A J Hall,et al.  Results of case-control study of leukaemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria. , 1990, BMJ.

[22]  Richard Doll,et al.  CANCER NEAR POTENTIAL SITES OF NUCLEAR INSTALLATIONS , 1989, The Lancet.

[23]  K. Jones,et al.  Obstetric Outcomes in West Cumberland Hospital: Is There a Risk from Sellafield? , 1989, Journal of the Royal Society of Medicine.

[24]  Richard Doll,et al.  The Epidemiology of Childhood Leukaemia , 1989 .

[25]  S. C. Darby,et al.  Geographical variation in mortality from leukaemia and other cancers in England and Wales in relation to proximity to nuclear installations, 1969-78. , 1989, British Journal of Cancer.

[26]  Leo Kinlen,et al.  EVIDENCE FOR AN INFECTIVE CAUSE OF CHILDHOOD LEUKAEMIA: COMPARISON OF A SCOTTISH NEW TOWN WITH NUCLEAR REPROCESSING SITES IN BRITAIN , 1988, The Lancet.

[27]  J. Neel,et al.  Search for mutations altering protein charge and/or function in children of atomic bomb survivors: final report. , 1988, American journal of human genetics.

[28]  E. Knox,et al.  Background radiation and childhood cancers , 1988 .

[29]  R. Doll,et al.  Estimated radiation doses to different organs among patients treated for ankylosing spondylitis with a single course of X rays. , 1988, The British journal of radiology.

[30]  P Fraser,et al.  Radiation dose and leukemia risk in patients treated for cancer of the cervix. , 1987, Journal of the National Cancer Institute.

[31]  E. Rappaport,et al.  Childhood leukemia and parents' occupational and home exposures. , 1987, Journal of the National Cancer Institute.

[32]  B. Cattanach,et al.  Specific-locus mutation response to unequal, 1 + 9 Gy X-ray fractionations at 24-h and 4-day fraction intervals. , 1985, Mutation research.

[33]  R. Prentice.  Covariate measurement errors and parameter estimation in a failure time regression model , 1982 .

[34]  T. Nomura.  Parental exposure to X rays and chemicals induces heritable tumours and anomalies in mice. , 1982, Nature.

[35]  P G Smith,et al.  Mortality among patients with ankylosing spondylitis after a single treatment course with x rays. , 1982, British medical journal.

[36]  B. Cattanach,et al.  Sterile period, translocation and specific locus mutation in the mouse following fractionated x-ray treatments with different fractionation intervals. , 1974, Mutation research.

[37]  A. Knudson.  Mutation and cancer: statistical study of retinoblastoma. , 1971, Proceedings of the National Academy of Sciences of the United States of America.

[38]  M. Lyon,et al.  Gene and chromosome mutation after large fractionated or unfractionated radiation doses to mouse spermatogonia. , 1969, Mutation research.

[39]  W. Russell.  An augmenting effect of dose fractionation on radiation-induced mutation rate in mice. , 1962, Proceedings of the National Academy of Sciences of the United States of America.

[40]  S. Narod.  Radiation, genetics and childhood leukaemia. , 1990, European journal of cancer.

[41]  A. Awa,et al.  Cytogenetic Study of the Offspring of Atomic Bomb Survivors, Hiroshima and Nagasaki , 1987 .