Predictors of Adverse Outcome in Patients Hospitalised for Exacerbation of Chronic Obstructive Pulmonary Disease

Background: It is crucial to identify risk factors for poor evolution of patients admitted to hospital with chronic obstructive pulmonary disease (COPD) in order to provide adequate intensive therapy and closer follow-up. Objectives: To identify predictors of adverse outcomes in patients hospitalised for exacerbation of COPD. Methods: A prospective, observational study was conducted in patients admitted for exacerbation of COPD. Demographic and clinical parameters were evaluated, including different multidimensional prognostic scores. Adverse outcomes included the following: death during hospitalisation or 1-month follow-up, intensive care unit admission, invasive or non-invasive mechanical ventilation, prolonged hospitalisation ( 1 11 days) and COPD-related emergency visit or readmission within 1 month after discharge. Univariate and multivariate analysis were performed. Results: Of 155 patients included, an adverse outcome occurred in 69 (45%). Patients with an adverse outReceived: October 12, 2011 Accepted after revision: November 24, 2011 Published online: February 11, 2012 Marc Miravitlles Servei de Pneumologia, Hospital Clínic Villarroel 170 ES–08036 Barcelona (Spain) Tel. +34 93 227 5549, E-Mail marcm @ separ.es © 2012 S. Karger AG, Basel 0025–7931/12/0841–0017$38.00/0 Accessible online at: www.karger.com/res For editorial comment see p. 12

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