Quantitative assessment of amide proton transfer (APT) and nuclear overhauser enhancement (NOE) imaging with extrapolated semi‐solid magnetization transfer reference (EMR) signals: Application to a rat glioma model at 4.7 tesla

To quantify amide proton transfer (APT) and nuclear Overhauser enhancement (NOE) contributions to in vivo chemical exchange saturation transfer MRI signals in tumors.

[1]  Peter Bachert,et al.  On the origins of chemical exchange saturation transfer (CEST) contrast in tumors at 9.4 T , 2014, NMR in biomedicine.

[2]  A Dean Sherry,et al.  Chemical exchange saturation transfer contrast agents for magnetic resonance imaging. , 2008, Annual review of biomedical engineering.

[3]  Nirbhay N. Yadav,et al.  Chemical exchange saturation transfer (CEST): What is in a name and what isn't? , 2011, Magnetic resonance in medicine.

[4]  C. Morrison,et al.  A Model for Magnetization Transfer in Tissues , 1995, Magnetic resonance in medicine.

[5]  P. Jezzard,et al.  Comparing different analysis methods for quantifying the MRI amide proton transfer (APT) effect in hyperacute stroke patients , 2014, NMR in biomedicine.

[6]  Peter Jezzard,et al.  Quantitative Bayesian model‐based analysis of amide proton transfer MRI , 2013, Magnetic resonance in medicine.

[7]  Jinyuan Zhou,et al.  Amide proton transfer (APT) contrast for imaging of brain tumors , 2003, Magnetic resonance in medicine.

[8]  Xuna Zhao,et al.  Saturation power dependence of amide proton transfer image contrasts in human brain tumors and strokes at 3 T , 2011, Magnetic resonance in medicine.

[9]  Vaibhav A. Janve,et al.  Multi‐angle ratiometric approach to measure chemical exchange in amide proton transfer imaging , 2012, Magnetic resonance in medicine.

[10]  Jinyuan Zhou,et al.  Quantitative description of proton exchange processes between water and endogenous and exogenous agents for WEX, CEST, and APT experiments , 2004, Magnetic resonance in medicine.

[11]  Jinyuan Zhou,et al.  Quantitative characterization of nuclear overhauser enhancement and amide proton transfer effects in the human brain at 7 tesla , 2013, Magnetic resonance in medicine.

[12]  Susumu Mori,et al.  Mechanism of magnetization transfer during on‐resonance water saturation. A new approach to detect mobile proteins, peptides, and lipids , 2003, Magnetic resonance in medicine.

[13]  Jinyuan Zhou,et al.  Chemical exchange saturation transfer imaging and spectroscopy , 2006 .

[14]  B Quesson,et al.  Magnetization transfer fast imaging of implanted glioma in the rat brain at 4.7 T: Interpretation using a binary spin‐bath model , 1997, Journal of magnetic resonance imaging : JMRI.

[15]  Tao Jin,et al.  Magnetic resonance imaging of the Amine–Proton EXchange (APEX) dependent contrast , 2012, NeuroImage.

[16]  John A. Detre,et al.  Magnetic Resonance Imaging of Glutamate , 2011, Nature Medicine.

[17]  Gil Navon,et al.  Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST) , 2008, Proceedings of the National Academy of Sciences.

[18]  O. Togao,et al.  Characterization of Lung Cancer by Amide Proton Transfer (APT) Imaging: An In-Vivo Study in an Orthotopic Mouse Model , 2013, PloS one.

[19]  Alain Pitiot,et al.  High‐resolution imaging of magnetisation transfer and nuclear Overhauser effect in the human visual cortex at 7 T , 2013, NMR in biomedicine.

[20]  Jinyuan Zhou,et al.  Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI , 2003, Nature Medicine.

[21]  Xavier Golay,et al.  Amide proton transfer imaging of human brain tumors at 3T , 2006, Magnetic resonance in medicine.

[22]  Jinyuan Zhou,et al.  Three‐dimensional amide proton transfer MR imaging of gliomas: Initial experience and comparison with gadolinium enhancement , 2013, Journal of magnetic resonance imaging : JMRI.

[23]  P. V. van Zijl,et al.  Suppression of lipid artifacts in amide proton transfer imaging , 2005, Magnetic resonance in medicine.

[24]  Peter Bachert,et al.  Quantitative separation of CEST effect from magnetization transfer and spillover effects by Lorentzian-line-fit analysis of z-spectra. , 2011, Journal of magnetic resonance.

[25]  G. B. Pike,et al.  Quantitative imaging of magnetization transfer exchange and relaxation properties in vivo using MRI , 2001, Magnetic resonance in medicine.

[26]  Jinyuan Zhou,et al.  Practical data acquisition method for human brain tumor amide proton transfer (APT) imaging , 2008, Magnetic resonance in medicine.

[27]  John C Gore,et al.  Imaging amide proton transfer and nuclear overhauser enhancement using chemical exchange rotation transfer (CERT) , 2014, Magnetic resonance in medicine.

[28]  C. Cai,et al.  Observation of true and pseudo NOE signals using CEST‐MRI and CEST‐MRS sequences with and without lipid suppression , 2015, Magnetic resonance in medicine.

[29]  P. Z. Sun.  Simplified and scalable numerical solution for describing multi-pool chemical exchange saturation transfer (CEST) MRI contrast. , 2010, Journal of magnetic resonance.

[30]  Kimberly L Desmond,et al.  Mapping of amide, amine, and aliphatic peaks in the CEST spectra of murine xenografts at 7 T , 2014, Magnetic resonance in medicine.

[31]  Yoshinori Kato,et al.  Natural D‐glucose as a biodegradable MRI contrast agent for detecting cancer , 2012, Magnetic resonance in medicine.

[32]  Jinyuan Zhou,et al.  Detection of the Ischemic Penumbra Using pH-Weighted MRI , 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[33]  A. Sherry,et al.  A novel europium(III)-based MRI contrast agent. , 2001, Journal of the American Chemical Society.

[34]  Craig K. Jones,et al.  Four‐pool modeling of proton exchange processes in biological systems in the presence of MRI–paramagnetic chemical exchange saturation transfer (PARACEST) agents , 2008, Magnetic resonance in medicine.

[35]  Matthew E Merritt,et al.  Numerical solution of the Bloch equations provides insights into the optimum design of PARACEST agents for MRI , 2005, Magnetic resonance in medicine.

[36]  Jinyuan Zhou,et al.  Defining an Acidosis-Based Ischemic Penumbra from pH-Weighted MRI , 2011, Translational Stroke Research.

[37]  M. Bronskill,et al.  Characterizing white matter with magnetization transfer and T2 , 1999, Magnetic resonance in medicine.

[38]  Jinyuan Zhou,et al.  MR imaging of high-grade brain tumors using endogenous protein and peptide-based contrast , 2010, NeuroImage.

[39]  S. Walter Englander,et al.  Hydrogen exchange , 2001, Nature Structural Biology.

[40]  Gottfried Otting,et al.  Proton exchange rates from amino acid side chains— implications for image contrast , 1996, Magnetic resonance in medicine.

[41]  Jinyuan Zhou,et al.  Quantitative description of the asymmetry in magnetization transfer effects around the water resonance in the human brain , 2007, Magnetic resonance in medicine.

[42]  Robert E Lenkinski,et al.  CEST: from basic principles to applications, challenges and opportunities. , 2013, Journal of magnetic resonance.

[43]  Edward Pan,et al.  In vivo chemical exchange saturation transfer imaging allows early detection of a therapeutic response in glioblastoma , 2014, Proceedings of the National Academy of Sciences.

[44]  Tao Jin,et al.  MR imaging of the amide‐proton transfer effect and the pH‐insensitive nuclear overhauser effect at 9.4 T , 2013, Magnetic resonance in medicine.

[45]  Jinyuan Zhou,et al.  Amide proton transfer MR imaging of prostate cancer: A preliminary study , 2011, Journal of magnetic resonance imaging : JMRI.

[46]  Bennett A Landman,et al.  Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments , 2009, Magnetic resonance in medicine.

[47]  R S Balaban,et al.  A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST). , 2000, Journal of magnetic resonance.

[48]  Craig R Malloy,et al.  MRI thermometry based on PARACEST agents. , 2005, Journal of the American Chemical Society.

[49]  Ravinder R Regatte,et al.  Isolating chemical exchange saturation transfer contrast from magnetization transfer asymmetry under two-frequency rf irradiation. , 2012, Journal of magnetic resonance.

[50]  Yuguo Li,et al.  Design and characterization of a new irreversible responsive PARACEST MRI contrast agent that detects nitric oxide , 2007, Magnetic resonance in medicine.

[51]  Jinyuan Zhou,et al.  Amide proton transfer imaging of 9L gliosarcoma and human glioblastoma xenografts , 2008, NMR in biomedicine.

[52]  G. Barker,et al.  Precise estimate of fundamental in-vivo MT parameters in human brain in clinically feasible times. , 2002, Magnetic resonance imaging.

[53]  Enzo Terreno,et al.  Iopamidol: Exploring the potential use of a well‐established x‐ray contrast agent for MRI , 2005, Magnetic resonance in medicine.

[54]  Koji Yamashita,et al.  Amide proton transfer imaging of adult diffuse gliomas: correlation with histopathological grades. , 2014, Neuro-oncology.

[55]  Peter Bachert,et al.  Chemical exchange saturation transfer (CEST) and MR Z-spectroscopy in vivo: a review of theoretical approaches and methods , 2013, Physics in medicine and biology.

[56]  Mark F. Lythgoe,et al.  In vivo imaging of glucose uptake and metabolism in tumors , 2012, Nature Medicine.

[57]  Thomas E Yankeelov,et al.  Amide proton transfer imaging of the breast at 3 T: Establishing reproducibility and possible feasibility assessing chemotherapy response , 2013, Magnetic resonance in medicine.

[58]  Robert Bartha,et al.  Quantitative Tissue Ph Measurement during Cerebral Ischemia Using Amine and Amide Concentration-Independent Detection (AACID) with MRI , 2014, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[59]  Leif Østergaard,et al.  Assessment of ischemic penumbra in patients with hyperacute stroke using amide proton transfer (APT) chemical exchange saturation transfer (CEST) MRI , 2014, NMR in biomedicine.

[60]  Jinyuan Zhou,et al.  Quantitative multiparametric MRI assessment of glioma response to radiotherapy in a rat model. , 2014, Neuro-oncology.

[61]  Jinyuan Zhou,et al.  In vivo three‐dimensional whole‐brain pulsed steady‐state chemical exchange saturation transfer at 7 T , 2012, Magnetic resonance in medicine.

[62]  Erik Tryggestad,et al.  Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides , 2010, Nature Medicine.

[63]  R M Henkelman,et al.  Quantitative interpretation of magnetization transfer , 1993, Magnetic resonance in medicine.

[64]  Richard A. E. Edden,et al.  Nuclear Overhauser enhancement (NOE) imaging in the human brain at 7T , 2013, NeuroImage.

[65]  Ravinder Reddy,et al.  A technique for in vivo mapping of myocardial creatine kinase metabolism , 2014, Nature Medicine.

[66]  Jing Yuan,et al.  APT‐weighted and NOE‐weighted image contrasts in glioma with different RF saturation powers based on magnetization transfer ratio asymmetry analyses , 2013, Magnetic resonance in medicine.