Interstitial photodynamic therapy of nonresectable malignant glioma recurrences using 5‐aminolevulinic acid induced protoporphyrin IX

Limited knowledge of the light and temperature distribution within the target volume in combination with non‐selective accumulation of the applied photosensitizers (PS) has hampered the clinical relevance of interstitial photodynamic therapy (iPDT) for treatment of malignant glioma patients. The current pilot study focused on the development and the clinical implementation of an accurate and reproducible irradiation scheme for iPDT using 5‐aminolevulinic acid (5‐ALA) induced protoporphyrin IX (PPIX) as a selectively working PS.

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