The TPM3‐NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition

[1]  Amar Gajjar,et al.  The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma , 2014, Nature Genetics.

[2]  Jinkuk Kim,et al.  NTRK1 Fusion in Glioblastoma Multiforme , 2014, PloS one.

[3]  David M. Jones,et al.  New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing. , 2014, The oncologist.

[4]  Iwei Yeh,et al.  Kinase fusions are frequent in Spitz tumours and spitzoid melanomas , 2014, Nature Communications.

[5]  Jeffrey A. Engelman,et al.  Tyrosine kinase gene rearrangements in epithelial malignancies , 2013, Nature Reviews Cancer.

[6]  L. Garraway,et al.  Oncogenic and drug sensitive NTRK1 rearrangements in lung cancer , 2013, Nature Medicine.

[7]  J. Tabernero,et al.  Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. , 2013, The New England journal of medicine.

[8]  A. D’Incecco,et al.  Targeted therapy for NSCLC with driver mutations , 2013, Expert opinion on biological therapy.

[9]  M. Ladanyi,et al.  ALK Rearrangements Are Mutually Exclusive with Mutations in EGFR or KRAS: An Analysis of 1,683 Patients with Non–Small Cell Lung Cancer , 2013, Clinical Cancer Research.

[10]  Seung-Yong Jeong,et al.  Targeted Sequencing of Cancer-Related Genes in Colorectal Cancer Using Next-Generation Sequencing , 2013, PloS one.

[11]  Angelo Nuzzo,et al.  Cell line identity finding by fingerprinting, an optimized resource for short tandem repeat profile authentication. , 2013, Genetic testing and molecular biomarkers.

[12]  Y. Indo,et al.  Nerve growth factor and the physiology of pain: lessons from congenital insensitivity to pain with anhidrosis , 2012, Clinical genetics.

[13]  Melanie A. Huntley,et al.  Recurrent R-spondin fusions in colon cancer , 2012, Nature.

[14]  Steven J. M. Jones,et al.  Comprehensive molecular characterization of human colon and rectal cancer , 2012, Nature.

[15]  Jeffrey W. Clark,et al.  ROS1 rearrangements define a unique molecular class of lung cancers. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[16]  Adam A. Margolin,et al.  The Cancer Cell Line Encyclopedia enables predictive modeling of anticancer drug sensitivity , 2012, Nature.

[17]  Doron Lipson,et al.  Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies , 2012, Nature Medicine.

[18]  A. Isacchi,et al.  The generation of purinome-targeted libraries as a means to diversify ATP-mimetic chemical classes for lead finding , 2012, Molecular Diversity.

[19]  A. Tsao,et al.  ROS1 Rearrangements Define a Unique Molecular Class of Lung Cancers , 2012 .

[20]  F. Fiorentini,et al.  NMS-P937, a 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitor. , 2011, Bioorganic & Medicinal Chemistry Letters.

[21]  G. Webersinke,et al.  Characterization of a newly identified ETV6-NTRK3 fusion transcript in acute myeloid leukemia , 2011, Diagnostic pathology.

[22]  A. Isacchi,et al.  102 Identification and preclinical characterization of NMS-P626, a potent, selective and orally bioavailable TrkA inhibitor with anti-tumor activity in a TrkA-dependent colorectal cancer , 2010 .

[23]  B. Nordlinger,et al.  Colorectal cancer – Authors' reply , 2010, The Lancet.

[24]  M. A. Pierotti,et al.  Rearrangements of NTRK1 gene in papillary thyroid carcinoma , 2010, Molecular and Cellular Endocrinology.

[25]  A. Bardelli,et al.  Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[26]  A. Bardelli,et al.  Biomarkers Predicting Clinical Outcome of Epidermal Growth Factor Receptor–Targeted Therapy in Metastatic Colorectal Cancer , 2009, Journal of the National Cancer Institute.

[27]  D. Cunningham,et al.  Treatment in advanced colorectal cancer: what, when and how? , 2009, British Journal of Cancer.

[28]  Giovanni Parmigiani,et al.  Mutational Analysis of the Tyrosine Kinome in Colorectal Cancers , 2003, Nature Reviews Cancer.

[29]  P. Sorensen,et al.  Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. , 2002, Cancer cell.

[30]  D. Gisselsson,et al.  ETV6 Rearrangements in Patients with Infantile Fibrosarcomas and Congenital Mesoblastic Nephromas by Fluorescence In Situ Hybridization , 2001, Modern Pathology.

[31]  David R Kaplan,et al.  Neurotrophin signal transduction in the nervous system , 2000, Current Opinion in Neurobiology.

[32]  P. Sorensen,et al.  The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells , 2000, Oncogene.

[33]  M. Pierotti,et al.  A novel NTRK1 mutation associated with congenital insensitivity to pain with anhidrosis. , 1999, American journal of human genetics.

[34]  G. Evan,et al.  Specific TrkA survival signals interfere with different apoptotic pathways , 1998, Oncogene.

[35]  P. Sorensen,et al.  A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma , 1998, Nature Genetics.

[36]  M. Pierotti,et al.  Chromosome I rearrangements involving the genes TPR and NTRK1 produce structurally different thyroid‐specific TRK oncogenes , 1997, Genes, chromosomes & cancer.

[37]  R. Stephens,et al.  Autophosphorylation of Activation Loop Tyrosines Regulates Signaling by the TRK Nerve Growth Factor Receptor* , 1997, The Journal of Biological Chemistry.

[38]  D. Kaplan,et al.  Signal transduction by the neutrophin receptors , 1997 .

[39]  D. Kaplan,et al.  Signal transduction by the neurotrophin receptors. , 1997, Current opinion in cell biology.

[40]  M. Borrello,et al.  A sequence analysis of the genomic regions involved in the rearrangements between TPM3 and NTRK1 genes producing TRK oncogenes in papillary thyroid carcinomas. , 1995, Genomics.

[41]  G. Yancopoulos,et al.  Neurotrophic factors and their receptors , 1994, Annals of neurology.

[42]  W. Snider,et al.  Functions of the neurotrophins during nervous system development: What the knockouts are teaching us , 1994, Cell.

[43]  T. Pawson,et al.  Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses , 1994, Neuron.

[44]  M. Pierotti,et al.  TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas. , 1992, Oncogene.

[45]  J. Bishop,et al.  Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[46]  A. Lupas,et al.  Predicting coiled coils from protein sequences , 1991, Science.

[47]  D. Kaplan,et al.  The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. , 1991, Science.

[48]  D. Kaplan,et al.  Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF , 1991, Nature.

[49]  M. Barbacid,et al.  Human trk oncogenes activated by point mutation, in-frame deletion, and duplication of the tyrosine kinase domain , 1990, Molecular and cellular biology.

[50]  I. Fidler,et al.  Influence of organ environment on the growth, selection, and metastasis of human colon carcinoma cells in nude mice. , 1988, Cancer research.

[51]  G. Daley,et al.  Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[52]  Q. Sattentau,et al.  HIV infection of primate lymphocytes and conservation of the CD4 receptor , 1987, Nature.

[53]  R. Levi‐montalcini,et al.  The nerve growth factor 35 years later. , 1987, Science.

[54]  M. Barbacid,et al.  A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences , 1986, Nature.