Toward a Neurogenetic Theory of Neuroticism

Recent advances in neuroscience and molecular biology have begun to identify neural and genetic correlates of complex traits. Future theories of personality need to integrate these data across the behavioral, neural, and genetic level of analysis and further explain the underlying epigenetic processes by which genes and environmental variables interact to shape the structure and function of neural circuitry. In this chapter, I will review some of the work that has been conducted at the cognitive, neural, and molecular genetic level with respect to one specific personality trait—neuroticism. I will focus particularly on individual differences with respect to memory, self‐reference, perception, and attention during processing of emotional stimuli and the significance of gene‐by‐environment interactions. This chapter is intended to serve as a tutorial bridge for psychologists who may be intrigued by molecular genetics and for molecular biologists who may be curious about how to apply their research to the study of personality.

[1]  J. D. McGaugh,et al.  Beta-adrenergic activation and memory for emotional events. , 1994, Nature.

[2]  J. Desmond,et al.  An fMRI study of personality influences on brain reactivity to emotional stimuli. , 2001, Behavioral neuroscience.

[3]  Bryan T. Denny,et al.  Medial prefrontal activity differentiates self from close others. , 2006, Social cognitive and affective neuroscience.

[4]  K. Lesch,et al.  Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on emotional processing. , 2006, Cerebral cortex.

[5]  D. Boomsma,et al.  Editorial: Genetics of Brain Function and Cognition , 2001, Behavior genetics.

[6]  W. Drevets,et al.  Discovering Endophenotypes for Major Depression , 2004, Neuropsychopharmacology.

[7]  M. Burmeister,et al.  Meta‐analysis of the association between a serotonin transporter promoter polymorphism (5‐HTTLPR) and anxiety‐related personality traits , 2004, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[8]  Andreas Meyer-Lindenberg,et al.  Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation. , 2006, Archives of general psychiatry.

[9]  M. Owen,et al.  The genetic basis of complex human behaviors. , 1994, Science.

[10]  N. Alpert,et al.  Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography. , 1994, Archives of general psychiatry.

[11]  E. Coccaro,et al.  Molecular genetics of personality , 2005, Current psychiatry reports.

[12]  Maryanne Martin.  Neuroticism as predisposition toward depression: A cognitive mechanism. , 1985 .

[13]  R. Busch,et al.  A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety , 2004, Molecular Psychiatry.

[14]  A. Caspi,et al.  Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene , 2003, Science.

[15]  J. Gray,et al.  The psychophysiological basis of introversion-extraversion. , 1970, Behaviour research and therapy.

[16]  D. Stein,et al.  The relationship between childhood abuse and dissociation. Is it influenced by catechol-O-methyltransferase (COMT) activity? , 2008, The international journal of neuropsychopharmacology.

[17]  Scott T. Grafton,et al.  Amygdala activity related to enhanced memory for pleasant and aversive stimuli , 1999, Nature Neuroscience.

[18]  Kevin N. Ochsner,et al.  For better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotion , 2004, NeuroImage.

[19]  Andreas Papassotiropoulos,et al.  Identification of a genetic cluster influencing memory performance and hippocampal activity in humans. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[20]  A. Korten,et al.  COMT and DRD3 polymorphisms, environmental exposures, and personality traits related to common mental disorders. , 2000, American journal of medical genetics.

[21]  M. Botvinick,et al.  Conflict monitoring and cognitive control. , 2001, Psychological review.

[22]  I. Gottesman,et al.  The endophenotype concept in psychiatry: etymology and strategic intentions. , 2003, The American journal of psychiatry.

[23]  C. MacLeod,et al.  Anxiety and the Allocation of Attention to Threat , 1988, The Quarterly journal of experimental psychology. A, Human experimental psychology.

[24]  Michael F Egan,et al.  A susceptibility gene for affective disorders and the response of the human amygdala. , 2005, Archives of general psychiatry.

[25]  A. Richards,et al.  Effects of mood manipulation and anxiety on performance of an emotional Stroop task. , 1992, British journal of psychology.

[26]  K. Lesch,et al.  The utility of the non‐human primate model for studying gene by environment interactions in behavioral research , 2003, Genes, brain, and behavior.

[27]  Brien Riley,et al.  The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. , 2005, Archives of general psychiatry.

[28]  K. Lesch,et al.  Toward a molecular architecture of personality , 2003, Behavioural Brain Research.

[29]  Daniel R. Weinberger,et al.  Variation of Human Amygdala Response During Threatening Stimuli as a Function of 5′HTTLPR Genotype and Personality Style , 2005, Biological Psychiatry.

[30]  A. Meyer-Lindenberg,et al.  5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression , 2005, Nature Neuroscience.

[31]  K. Luan Phan,et al.  Functional Neuroanatomy of Emotion: A Meta-Analysis of Emotion Activation Studies in PET and fMRI , 2002, NeuroImage.

[32]  A. Serretti,et al.  Serotonin transporter gene variants and behavior: a comprehensive review. , 2006, Current drug targets.

[33]  N C Andreasen,et al.  Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flow , 2005 .

[34]  Jane F. Banfield,et al.  Medial prefrontal activity predicts memory for self. , 2004, Cerebral cortex.

[35]  D. Levinson.  The Genetics of Depression: A Review , 2006, Biological Psychiatry.

[36]  Andreas Papassotiropoulos,et al.  The prion gene is associated with human long-term memory. , 2005, Human molecular genetics.

[37]  N. Martin,et al.  The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression , 2005, Psychological Medicine.

[38]  M. Munafo,et al.  Promise and pitfalls in the meta-analysis of genetic association studies: a response to Sen and Schinka , 2005, Molecular Psychiatry.

[39]  Gary H. Glover,et al.  fMRI identifies a network of structures correlated with retention of positive and negative emotional memory , 1999, Psychobiology.

[40]  R. Weksberg,et al.  Catechol-O-methyl Transferase and Expression of Schizophrenia in 73 Adults with 22q11 Deletion Syndrome , 2007, Biological Psychiatry.

[41]  J L McGaugh,et al.  Amygdala activity at encoding correlated with long-term, free recall of emotional information. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[42]  Alexander Strobel,et al.  Interaction between BDNF Val66Met and Dopamine Transporter Gene Variation Influences Anxiety-Related Traits , 2007, Neuropsychopharmacology.

[43]  I. Craig.  The role of monoamine oxidase A, MAOA, in the aetiology of antisocial behaviour: the importance of gene-environment interactions. , 2005, Novartis Foundation symposium.

[44]  P. Costa,et al.  Influence of extraversion and neuroticism on subjective well-being: happy and unhappy people. , 1980, Journal of personality and social psychology.

[45]  M. Raichle,et al.  Subgenual prefrontal cortex abnormalities in mood disorders , 1997, Nature.

[46]  J. Gabrieli,et al.  Event-Related Activation in the Human Amygdala Associates with Later Memory for Individual Emotional Experience , 2000, The Journal of Neuroscience.

[47]  R. T. Constable,et al.  Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation , 2005, Journal of Neural Transmission.

[48]  E. Stern,et al.  Linguistic threat activates the human amygdala. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[49]  R. C. Fraley,et al.  Daily depression and cognitions about stress: evidence for a traitlike depressogenic cognitive style and the prediction of depressive symptoms in a prospective daily diary study. , 2005, Journal of personality and social psychology.

[50]  I. Deary,et al.  Neuroticism and polymorphisms in the serotonin transporter gene , 1999, Psychological Medicine.

[51]  A. Buss,et al.  Personality Traits , 1973 .

[52]  M. Posner,et al.  Cognitive and emotional influences in anterior cingulate cortex , 2000, Trends in Cognitive Sciences.

[53]  Herbert Oberacher,et al.  Differential effect of catechol-O-methyltransferase Val158Met genotype on emotional recognition abilities in healthy men and women , 2007, Journal of the International Neuropsychological Society.

[54]  Timothy Edward John Behrens,et al.  Contrasting roles for cingulate and orbitofrontal cortex in decisions and social behaviour , 2007, Trends in Cognitive Sciences.

[55]  M. Munafo,et al.  Genetic Polymorphisms and Personality in Healthy Adults: A systematic review and meta-analysis , 2003, Molecular Psychiatry.

[56]  F. Castellanos,et al.  Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes , 2002, Nature Reviews Neuroscience.

[57]  Eric R. Kandel,et al.  Individual Differences in Trait Anxiety Predict the Response of the Basolateral Amygdala to Unconsciously Processed Fearful Faces , 2004, Neuron.

[58]  K. Lesch,et al.  Early experience and serotonin transporter gene variation interact to influence primate CNS function , 2002, Molecular Psychiatry.

[59]  D. Murphy,et al.  Non-linear association between the serotonin transporter promoter polymorphism and neuroticism: a caution against using extreme samples to identify quantitative trait loci. , 1999, Psychiatric genetics.

[60]  T. Moffitt,et al.  The new look of behavioral genetics in developmental psychopathology: gene-environment interplay in antisocial behaviors. , 2005, Psychological bulletin.

[61]  Michael J Meaney,et al.  Epigenetic programming by maternal behavior , 2004, Nature Neuroscience.

[62]  P. R. Mayo.  Personality traits and the retrieval of positive and negative memories , 1983 .

[63]  M. Egan,et al.  Serotonin Transporter Genetic Variation and the Response of the Human Amygdala , 2002, Science.

[64]  B. Vogt,et al.  Contributions of anterior cingulate cortex to behaviour. , 1995, Brain : a journal of neurology.

[65]  Thomas E. Nichols,et al.  Impact of complex genetic variation in COMT on human brain function , 2006, Molecular Psychiatry.

[66]  C. N. Macrae,et al.  Finding the Self? An Event-Related fMRI Study , 2002, Journal of Cognitive Neuroscience.

[67]  W. Drevets,et al.  Toward Constructing an Endophenotype Strategy for Bipolar Disorders , 2006, Biological Psychiatry.

[68]  Andreas Heinz,et al.  Catechol-O-Methyltransferase val158met Genotype Affects Processing of Emotional Stimuli in the Amygdala and Prefrontal Cortex , 2005, The Journal of Neuroscience.

[69]  G. Glover,et al.  Reflecting upon Feelings: An fMRI Study of Neural Systems Supporting the Attribution of Emotion to Self and Other , 2004, Journal of Cognitive Neuroscience.

[70]  R. Larsen.  Neuroticism and selective encoding and recall of symptoms: evidence from a combined concurrent-retrospective study. , 1992, Journal of personality and social psychology.

[71]  Y Shoda,et al.  Reconciling processing dynamics and personality dispositions. , 1998, Annual review of psychology.

[72]  R Todd Constable,et al.  Emotional conflict and neuroticism: personality-dependent activation in the amygdala and subgenual anterior cingulate. , 2007, Behavioral neuroscience.

[73]  J. Callicott,et al.  Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia. , 2004, The American journal of psychiatry.

[74]  B. Neale,et al.  A genome scan of neuroticism in nicotine dependent smokers , 2005, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[75]  A. Hariri,et al.  Genetics of emotional regulation: the role of the serotonin transporter in neural function , 2006, Trends in Cognitive Sciences.

[76]  A. Caspi,et al.  Role of Genotype in the Cycle of Violence in Maltreated Children , 2002, Science.

[77]  D. Pine,et al.  Impaired recognition of fear facial expressions in 5-HTTLPR S-polymorphism carriers following tryptophan depletion , 2006, Psychopharmacology.

[78]  A. Grace,et al.  The Prefrontal Cortex Regulates Lateral Amygdala Neuronal Plasticity and Responses to Previously Conditioned Stimuli , 2003, The Journal of Neuroscience.

[79]  Eliza Congdon,et al.  Neural correlates of epigenesis , 2006, Proceedings of the National Academy of Sciences.

[80]  Jason J. Corneveaux,et al.  Common Kibra Alleles Are Associated with Human Memory Performance , 2006, Science.

[81]  H. Eysenck.  Biological Basis of Personality , 1963, Nature.

[82]  D. Fowles.  Jeffrey Gray's Contributions to Theories of Anxiety, Personality, and Psychopathology. , 2006 .

[83]  W. Drevets.  Neuroimaging Abnormalities in the Amygdala in Mood Disorders , 2003, Annals of the New York Academy of Sciences.

[84]  Andreas J. Fallgatter,et al.  Serotonin transporter promoter polymorphism influences topography of inhibitory motor control. , 1999, The international journal of neuropsychopharmacology.

[85]  John H Krystal,et al.  Social supports and serotonin transporter gene moderate depression in maltreated children. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[86]  R. Coppola,et al.  Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia. , 2003, Archives of general psychiatry.

[87]  Stella W. Y. Chan,et al.  Highly neurotic never-depressed students have negative biases in information processing , 2007, Psychological Medicine.

[88]  M. Egan,et al.  Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. , 2004, American journal of human genetics.

[89]  C. L. Rusting,et al.  Personality, mood, and cognitive processing of emotional information: three conceptual frameworks. , 1998, Psychological bulletin.

[90]  Christian Büchel,et al.  Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter , 2005, Nature Neuroscience.

[91]  M. Egan,et al.  Brain-Derived Neurotrophic Factor val66met Polymorphism Affects Human Memory-Related Hippocampal Activity and Predicts Memory Performance , 2003, The Journal of Neuroscience.

[92]  R. Larsen,et al.  Personality and susceptibility to positive and negative emotional states. , 1991, Journal of personality and social psychology.

[93]  Eliza Congdon,et al.  The endophenotype of impulsivity: reaching consilience through behavioral, genetic, and neuroimaging approaches. , 2005, Behavioral and cognitive neuroscience reviews.

[94]  Christopher Andrew,et al.  Differential neural responses to overt and covert presentations of facial expressions of fear and disgust , 2000, NeuroImage.

[95]  C. Olson,et al.  Functional heterogeneity in cingulate cortex: the anterior executive and posterior evaluative regions. , 1992, Cerebral cortex.

[96]  Ralph Adolphs,et al.  Is the Human Amygdala Specialized for Processing Social Information? , 2003, Annals of the New York Academy of Sciences.

[97]  Martial Van der Linden,et al.  Self-referential reflective activity and its relationship with rest: a PET study , 2005, NeuroImage.

[98]  M. Reuter,et al.  The influence of the dopaminergic system on cognitive functioning: A molecular genetic approach , 2005, Behavioural Brain Research.

[99]  Heather L. Urry,et al.  Failure to Regulate: Counterproductive Recruitment of Top-Down Prefrontal-Subcortical Circuitry in Major Depression , 2007, The Journal of Neuroscience.

[100]  M. Egan,et al.  Prefrontal neurons and the genetics of schizophrenia , 2001, Biological Psychiatry.

[101]  A. Hariri,et al.  A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity , 2005, Molecular Psychiatry.

[102]  Joseph E LeDoux,et al.  Contributions of the Amygdala to Emotion Processing: From Animal Models to Human Behavior , 2005, Neuron.

[103]  D. Schacter,et al.  See Blockindiscussions, Blockinstats, Blockinand Blockinauthor Blockinprofiles Blockinfor Blockinthis Blockinpublication Aging, Blockinself-referencing, Blockinand Blockinmedial Blockinprefrontal Cortex , 2022 .

[104]  L. DiLalla,et al.  Behavior genetics principles : perspectives in development, personality, and psychopathology , 2004 .

[105]  M. Nobile,et al.  Effect of the catechol‐O‐methyltransferase val158met genotype on children’s early phases of facial stimuli processing , 2007, Genes, brain, and behavior.

[106]  M. Posner,et al.  Assessing the molecular genetics of attention networks , 2002, BMC Neuroscience.

[107]  P. Cowen,et al.  Tryptophan depletion decreases the recognition of fear in female volunteers , 2003, Psychopharmacology.

[108]  Murray B Stein,et al.  Personality and anxiety disorders: a review. , 2003, Journal of personality disorders.

[109]  Eliza Congdon,et al.  Analysis of DRD4 and DAT polymorphisms and behavioral inhibition in healthy adults: Implications for impulsivity , 2008, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[110]  Bruce D. McCandliss,et al.  Testing the Efficiency and Independence of Attentional Networks , 2002, Journal of Cognitive Neuroscience.

[111]  A. Bandura.  Social Foundations of Thought and Action: A Social Cognitive Theory , 1985 .

[112]  I. Ulmanen,et al.  Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. , 1995, Biochemistry.

[113]  Lin He,et al.  Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD). , 2006, Human molecular genetics.

[114]  M. Munafo,et al.  Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? A meta-analysis , 2005, Molecular Psychiatry.

[115]  P. Cowen,et al.  Acute administration of nutritionally sourced tryptophan increases fear recognition , 2003, Psychopharmacology.

[116]  Timothy E. J. Behrens,et al.  Adaptive decision making and value in the anterior cingulate cortex , 2007, NeuroImage.

[117]  H. Flor,et al.  Gene–gene effects on central processing of aversive stimuli , 2007, Molecular Psychiatry.

[118]  Justin S. Feinstein,et al.  Increased amygdala and insula activation during emotion processing in anxiety-prone subjects. , 2007, The American journal of psychiatry.

[119]  John D E Gabrieli,et al.  Amygdala Response to Happy Faces as a Function of Extraversion , 2002, Science.

[120]  Edward T. Bullmore,et al.  Differential neural responses to overt and covert presentations of facial expressions of fear and disgust , 2000, NeuroImage.

[121]  D. Ball,et al.  The serotonin transporter gene and peer‐rated neuroticism , 1997, Neuroreport.

[122]  J. Mazziotta,et al.  Modulating emotional responses: effects of a neocortical network on the limbic system , 2000, Neuroreport.

[123]  Jonathan D. Cohen,et al.  Conflict monitoring and anterior cingulate cortex: an update , 2004, Trends in Cognitive Sciences.

[124]  A. Bandura.  Social cognitive theory of personality. , 1999 .

[125]  T A Ketter,et al.  Blunted left cingulate activation in mood disorder subjects during a response interference task (the Stroop). , 1997, The Journal of neuropsychiatry and clinical neurosciences.

[126]  Alfonso Troisi,et al.  Early Trauma and Increased Risk for Physical Aggression during Adulthood: The Moderating Role of MAOA Genotype , 2007, PloS one.

[127]  K. Lesch,et al.  CRSN Symposium : Focus on Depression , Part I Symposium du CRSN : le point sur la dépression , première partie Gene – environment interaction and the genetics of depression , 2004 .

[128]  D. Murphy,et al.  Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531 , 2006, Molecular Psychiatry.

[129]  Andreas Heinz,et al.  The Effects of Catechol O-methyltransferase Genotype on Brain Activation Elicited by Affective Stimuli and Cognitive Tasks , 2006, Reviews in the neurosciences.

[130]  John P A Ioannidis,et al.  Common genetic variants for breast cancer: 32 largely refuted candidates and larger prospects. , 2006, Journal of the National Cancer Institute.

[131]  S. Rauch,et al.  An fMRI study of anterior cingulate function in posttraumatic stress disorder , 2001, Biological Psychiatry.

[132]  G. Quirk,et al.  Neuronal signalling of fear memory , 2004, Nature Reviews Neuroscience.

[133]  Peter Graf,et al.  Personality predicts prospective memory task performance: an adult lifespan study. , 2007, Scandinavian journal of psychology.

[134]  J. Flint,et al.  Social Adversity, the Serotonin Transporter (5-HTTLPR) Polymorphism and Major Depressive Disorder , 2006, Biological Psychiatry.

[135]  George Bush,et al.  The emotional counting stroop paradigm: a functional magnetic resonance imaging probe of the anterior cingulate affective division , 1998, Biological Psychiatry.

[136]  Margit Burmeister,et al.  A BDNF Coding Variant is Associated with the NEO Personality Inventory Domain Neuroticism, a Risk Factor for Depression , 2003, Neuropsychopharmacology.

[137]  K. Lesch,et al.  Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region , 1996, Science.

[138]  Turhan Canli,et al.  Functional brain mapping of extraversion and neuroticism: learning from individual differences in emotion processing. , 2004, Journal of personality.

[139]  P. Baud.  Personality traits as intermediary phenotypes in suicidal behavior: Genetic issues , 2005, American journal of medical genetics. Part C, Seminars in medical genetics.

[140]  K. Kendler,et al.  A genome‐wide linkage analysis for the personality trait neuroticism in the Irish affected sib‐pair study of alcohol dependence , 2007, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[141]  S. Srivastava,et al.  The Big Five Trait taxonomy: History, measurement, and theoretical perspectives. , 1999 .

[142]  S. Rauch,et al.  Masked Presentations of Emotional Facial Expressions Modulate Amygdala Activity without Explicit Knowledge , 1998, The Journal of Neuroscience.

[143]  Michael D. Robinson,et al.  Rotten to the core: Neuroticism and implicit evaluations of the self , 2005 .

[144]  F. Craik,et al.  In search of the emotional self: an fMRI study using positive and negative emotional words. , 2003, The American journal of psychiatry.

[145]  Ahmad R. Hariri,et al.  Serotonin Transporter Genotype (5-HTTLPR): Effects of Neutral and Undefined Conditions on Amygdala Activation , 2007, Biological Psychiatry.

[146]  Janice M. Fullerton,et al.  Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism. , 2003, American journal of human genetics.

[147]  H. Eysenck.  Biological dimensions of personality. , 1990 .

[148]  R. Ebstein,et al.  An update on molecular genetic studies of human personality traits. , 2002, Applied bioinformatics.

[149]  John A. Detre,et al.  Genetic Variation in Serotonin Transporter Alters Resting Brain Function in Healthy Individuals , 2007, Biological Psychiatry.

[150]  K. Lesch,et al.  Long story short: the serotonin transporter in emotion regulation and social cognition , 2007, Nature Neuroscience.

[151]  M. Egan,et al.  The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function , 2003, Cell.

[152]  R. Plomin.  Behavioral genetics. , 1991, Research publications - Association for Research in Nervous and Mental Disease.

[153]  Turhan Canli,et al.  The emergence of genomic psychology , 2007, EMBO reports.

[154]  Georg Northoff,et al.  Self-referential processing in our brain—A meta-analysis of imaging studies on the self , 2006, NeuroImage.

[155]  S. Tsai,et al.  Association Study of a Brain-Derived Neurotrophic Factor (BDNF) Val66Met Polymorphism and Personality Trait and Intelligence in Healthy Young Females , 2004, Neuropsychobiology.

[156]  John Patrick Aggleton,et al.  The Amygdala : a functional analysis , 2000 .

[157]  Walter Mischel,et al.  Personality dispositions revisited and revised: A view after three decades. , 1990 .

[158]  W. Lishman.  The speed of recall of pleasant and unpleasant experiences , 1974, Psychological Medicine.

[159]  David Goldman,et al.  Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primates. , 2004, Archives of general psychiatry.

[160]  Brandon E. Gibb,et al.  Serotonin transporter genetic variation and biased attention for emotional word stimuli among psychiatric inpatients. , 2007, Journal of abnormal psychology.

[161]  Peter Boesiger,et al.  Better Memory and Neural Efficiency in Young Apolipoprotein E ε4 Carriers , 2007 .

[162]  A. Lozano,et al.  Deep Brain Stimulation for Treatment-Resistant Depression , 2005, Neuron.

[163]  J. Benjamin,et al.  DRD4 related to infant attention and information processing: a developmental link to ADHD? , 2001, Psychiatric genetics.

[164]  R Todd Constable,et al.  Beyond affect: a role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[165]  I. Craig,et al.  Genotyping Pooled DNA on Microarrays: A Systematic Genome Screen of Thousands of SNPs in Large Samples to Detect QTLs for Complex Traits , 2004, Behavior genetics.

[166]  Thomas Elbert,et al.  A deletion variant of the α2b-adrenoceptor is related to emotional memory in Europeans and Africans , 2007, Nature Neuroscience.

[167]  Brian W. Haas,et al.  Interference produced by emotional conflict associated with anterior cingulate activation , 2006, Cognitive, affective & behavioral neuroscience.

[168]  Katharina Henke,et al.  A functional genetic variation of the 5-HT2a receptor affects human memory , 2003, Nature Neuroscience.

[169]  K Konrad,et al.  Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder , 2005, Molecular Psychiatry.

[170]  C L Rusting.  Interactive effects of personality and mood on emotion-congruent memory and judgment. , 1999, Journal of personality and social psychology.

[171]  A. Meyer-Lindenberg,et al.  Prefrontal-Hippocampal Coupling During Memory Processing Is Modulated by COMT Val158Met Genotype , 2006, Biological Psychiatry.

[172]  K. Luan Phan,et al.  Valence, gender, and lateralization of functional brain anatomy in emotion: a meta-analysis of findings from neuroimaging , 2003, NeuroImage.

[173]  Janice M. Fullerton,et al.  The Val66Met Coding Variant of the Brain-Derived Neurotrophic Factor (BDNF) Gene Does Not Contribute Toward Variation in the Personality Trait Neuroticism , 2005, Biological Psychiatry.

[174]  G. Abecasis,et al.  Genome-wide linkage analysis of a composite index of neuroticism and mood-related scales in extreme selected sibships. , 2004, Human molecular genetics.

[175]  Andreas Buchmann,et al.  Calmodulin-binding transcription activator 1 (CAMTA1) alleles predispose human episodic memory performance. , 2007, Human molecular genetics.

[176]  J. Vaidya,et al.  The two general activation systems of affect: Structural findings, evolutionary considerations, and psychobiological evidence , 1999 .

[177]  M. Egan,et al.  Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine , 2003, Proceedings of the National Academy of Sciences of the United States of America.