论文信息 - Safety and immunogenicity of the intradermal Thai red cross (2-2-2-0-1-1) post exposure vaccination regimen in the Indian population using purified chick embryo cell rabies vaccine.

Safety and immunogenicity of the intradermal Thai red cross (2-2-2-0-1-1) post exposure vaccination regimen in the Indian population using purified chick embryo cell rabies vaccine.

PURPOSE To test the immunogenicity of the WHO recommended "2-2-2-0-1-1" post-exposure rabies vaccination regimen in Indian subjects to determine the feasibility of replacing crude sheep brain nerve tissue rabies vaccine with modern tissue culture rabies vaccine at major anti-rabies treatment centers throughout India. METHODS Purified chick embryo cell vaccine (PCECV) was administered in the dosage of 0.1 mL per site to 53 Indian subjects. RESULTS All subjects produced rabies antibodies above 0.5 IU/mL by day 14 post-vaccination. Only minor adverse reactions including swelling (6.6%), erythema (5.4%) and pain (1.4%) were observed for which no treatment was required. CONCLUSIONS This study demonstrated that PCECV is safe and highly immunogenic in Indian subjects when administered intradermally as 0.1 mL/site using the "2-2-2-0-1-1" post-exposure regimen.

[1] R. Ichhpujani,et al. Animal bites: the current management guidelines. , 2003, Indian journal of pediatrics.

[2] I. Kurane,et al. Antibody responses induced by immunization with a Japanese rabies vaccine determined by neutralization test and enzyme-linked immunosorbent assay. , 2002, Vaccine.

[3] S. Madhusudana,et al. Evaluation of two intradermal vaccination regimens using purified chick embryo cell vaccine for post-exposure prophylaxis of rabies. , 2001, The National medical journal of India.

[4] M. Aubert,et al. ELISA test for rabies antibody titration in orally vaccinated foxes sampled in the fields. , 2000, Vaccine.

[5] A. Banzhoff,et al. Antibody response of patients after postexposure rabies vaccination with small intradermal doses of purified chick embryo cell vaccine or purified Vero cell rabies vaccine. , 2000, Bulletin of the World Health Organization.

[6] Madhusudana Sn,et al. Response to purified chick embryo cell rabies vaccine administered intradermally for post-exposure prophylaxis. , 1997 .

[7] W. Chaeychomsri,et al. Intradermal simulated rabies postexposure prophylaxis using purified chick embryo rabies vaccine. , 1994, Journal of the Medical Association of Thailand = Chotmaihet thangphaet.