Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1α transcription coactivator

[1]  C. Block,et al.  Mechanisms linking obesity with cardiovascular disease , 2006, Nature.

[2]  B. P. Flemming,et al.  Gluconeogenesis: Re-evaluating the FOXO1–PGC-1α connection , 2006, Nature.

[3]  R. Eckel,et al.  Preventing cardiovascular disease and diabetes: a call to action from the American Diabetes Association and the American Heart Association. , 2006, Circulation.

[4]  Christoph Handschin,et al.  Metabolic control through the PGC-1 family of transcription coactivators. , 2005, Cell metabolism.

[5]  J. Jessurun,et al.  Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. , 2005, The Journal of clinical investigation.

[6]  T. Unterman,et al.  FoxO proteins in insulin action and metabolism , 2005, Trends in Endocrinology & Metabolism.

[7]  A. Goldfine,et al.  The cellular fate of glucose and its relevance in type 2 diabetes. , 2004, Endocrine reviews.

[8]  E. Kanaya,et al.  The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner. , 2004, The Biochemical journal.

[9]  B. Hemmings,et al.  Advances in protein kinase B signalling: AKTion on multiple fronts. , 2004, Trends in biochemical sciences.

[10]  T. Asano,et al.  Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement. , 2003, Diabetes.

[11]  M. Beylot,et al.  Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease. , 2003, Diabetes & metabolism.

[12]  A. Barthel,et al.  Novel concepts in insulin regulation of hepatic gluconeogenesis. , 2003, American journal of physiology. Endocrinology and metabolism.

[13]  M. Stoffel,et al.  Insulin regulates the activity of forkhead transcription factor Hnf-3β/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[14]  Anastasia Kralli,et al.  The Transcriptional Coactivator PGC-1 Regulates the Expression and Activity of the Orphan Nuclear Receptor Estrogen-Related Receptor α (ERRα)* , 2003, The Journal of Biological Chemistry.

[15]  Henriette Pilegaard,et al.  Exercise induces transient transcriptional activation of the PGC‐1α gene in human skeletal muscle , 2003, The Journal of physiology.

[16]  P. Puigserver,et al.  Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. , 2003, Endocrine reviews.

[17]  Daniel P. Kelly,et al.  Peroxisome Proliferator-activated Receptor Coactivator-1α (PGC-1α) Coactivates the Cardiac-enriched Nuclear Receptors Estrogen-related Receptor-α and -γ , 2002, The Journal of Biological Chemistry.

[18]  J. Shaw,et al.  Global and societal implications of the diabetes epidemic , 2001, Nature.

[19]  D. Accili,et al.  The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. , 2001, The Journal of clinical investigation.

[20]  Guillaume Adelmant,et al.  Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1 , 2001, Nature.

[21]  H. Yost,et al.  Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus , 2001, The EMBO journal.

[22]  K. Kaestner,et al.  Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ) , 2001 .

[23]  Toshiyuki Obata,et al.  Peptide and Protein Library Screening Defines Optimal Substrate Motifs for AKT/PKB* , 2000, The Journal of Biological Chemistry.

[24]  A. Barthel,et al.  Activation of Protein Kinase B/Akt Is Sufficient to Repress the Glucocorticoid and cAMP Induction of Phosphoenolpyruvate Carboxykinase Gene* , 1998, The Journal of Biological Chemistry.

[25]  Y. Yazaki,et al.  Potential Role of Protein Kinase B in Insulin-induced Glucose Transport, Glycogen Synthesis, and Protein Synthesis* , 1998, The Journal of Biological Chemistry.

[26]  M. Birnbaum,et al.  Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation* , 1996, The Journal of Biological Chemistry.

[27]  T. Harris,et al.  Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. , 2006, Cell metabolism.

[28]  Jerry Donovan,et al.  Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. , 2003, Nature.

[29]  J. McGarry.  Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. , 2002, Diabetes.

[30]  J. McGarry.  Dysregulation of Fatty Acid Metabolism in the Etiology of Type 2 Diabetes , 2001 .