Can lifestyle modification improve neurocognition? Rationale and design of the ENLIGHTEN clinical trial.

[1]  J. O’Keefe,et al.  The Effects of Statins on Prevention of Stroke and Dementia: A REVIEW , 2012, Journal of cardiopulmonary rehabilitation and prevention.

[2]  Ronald C Petersen,et al.  Physical exercise as a preventive or disease-modifying treatment of dementia and brain aging. , 2011, Mayo Clinic proceedings.

[3]  Jean Bouyer,et al.  Multiple imputation for estimation of an occurrence rate in cohorts with attrition and discrete follow-up time points: a simulation study , 2010, BMC medical research methodology.

[4]  Jeffrey N. Browndyke,et al.  Effects of the Dietary Approaches to Stop Hypertension Diet, Exercise, and Caloric Restriction on Neurocognition in Overweight Adults With High Blood Pressure , 2010, Hypertension.

[5]  S. Dabbo,et al.  Motivational Interviewing: Preparing People to Change Addictive Behavior , 1993 .

[6]  Jeffrey N. Browndyke,et al.  Aerobic Exercise and Neurocognitive Performance: A Meta-Analytic Review of Randomized Controlled Trials , 2010, Psychosomatic medicine.

[7]  J. Blumenthal,et al.  Diet and neurocognition: review of evidence and methodological considerations. , 2010, Current aging science.

[8]  D. Segal.  Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) , 2010 .

[9]  P. Lin,et al.  Effects of the DASH diet alone and in combination with exercise and weight loss on blood pressure and cardiovascular biomarkers in men and women with high blood pressure: the ENCORE study. , 2010, Archives of internal medicine.

[10]  A. Zonderman,et al.  Carotid Intimal Medial Thickness Predicts Cognitive Decline Among Adults Without Clinical Vascular Disease , 2009, Stroke.

[11]  George Mendelson,et al.  Book Reviews , 1995 .

[12]  C. Choi,et al.  Estimating the probability of stroke in Korean hypertensive patients visiting tertiary hospitals using a risk profile from the framingham study , 2009, BMC neurology.

[13]  W. Kraus,et al.  Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. , 2009, JAMA.

[14]  Linda Dobrzanska.  Motivational interviewing in health care: helping patients change behaviorMotivational interviewing in health care: helping patients change behavior Stephen Rollnick , WilliamMiller , ChristopherButler The Guilford Press210£16.9997815938561201593856121 , 2009 .

[15]  R. Mayeux,et al.  Mediterranean diet and mild cognitive impairment. , 2009, Archives of neurology.

[16]  S. Kreiner,et al.  Cognitive impairment as assessed by a short form of MMSE was predictive of mortality. , 2008, Journal of clinical epidemiology.

[17]  W. Mechelen,et al.  The Effects of Exercise on Cognition in Older Adults With and Without Cognitive Decline: A Systematic Review , 2008, Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine.

[18]  J. Grimley Evans,et al.  Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people. , 2008, The Cochrane database of systematic reviews.

[19]  A. Passaro,et al.  Markers of endothelial dysfunction in older subjects with late onset Alzheimer's disease or vascular dementia , 2008, Journal of the Neurological Sciences.

[20]  J. Foster,et al.  Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. , 2008, JAMA.

[21]  J. Manson,et al.  Primary Prevention of Stroke by Healthy Lifestyle , 2008, Circulation.

[22]  Luc Vanhees,et al.  Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment. , 2008, The Cochrane database of systematic reviews.

[23]  L. Appel,et al.  Alternatives for macronutrient intake and chronic disease: a comparison of the OmniHeart diets with popular diets and with dietary recommendations. , 2008, The American journal of clinical nutrition.

[24]  K. Rockwood,et al.  Prevention of CIND by physical activity: Different impact on VCI-ND compared with MCI , 2008, Journal of the Neurological Sciences.

[25]  F. Sandrini,et al.  Risk factors for the development of atherosclerosis in childhood and adolescence. , 2008, Arquivos brasileiros de cardiologia.

[26]  Steven G Heeringa,et al.  Prevalence of Cognitive Impairment without Dementia in the United States , 2008, Annals of Internal Medicine.

[27]  W. Miller,et al.  Motivational Interviewing in Health Care: Helping Patients Change Behavior , 2008 .

[28]  F. Hu,et al.  Adherence to a DASH-style diet and risk of coronary heart disease and stroke in women. , 2007, Archives of internal medicine.

[29]  K. Aytemir,et al.  Assessment of Endothelial Function in Alzheimer's Disease: Is Alzheimer's Disease a Vascular Disease? , 2007, Journal of the American Geriatrics Society.

[30]  P. Doraiswamy,et al.  Exercise and Pharmacotherapy in the Treatment of Major Depressive Disorder , 2007, Psychosomatic medicine.

[31]  Nilüfer Ertekin-Taner,et al.  Genetics of Alzheimer's disease: a centennial review. , 2007, Neurologic clinics.

[32]  N. Zawia,et al.  Environmental and dietary risk factors in Alzheimer’s disease , 2007, Expert review of neurotherapeutics.

[33]  P. Doraiswamy,et al.  Cerebrovascular Risk Factors, Vascular Disease, and Neuropsychological Outcomes in Adults With Major Depression , 2007, Psychosomatic medicine.

[34]  Kathryn Ziegler-Graham,et al.  Forecasting the global burden of Alzheimer’s disease , 2007, Alzheimer's & Dementia.

[35]  Yaakov Stern,et al.  Mediterranean diet, Alzheimer disease, and vascular mediation. , 2006, Archives of neurology.

[36]  S. Black,et al.  National Institute of Neurological Disorders and Stroke–Canadian Stroke Network Vascular Cognitive Impairment Harmonization Standards , 2006, Stroke.

[37]  Hilkka Soininen,et al.  Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study , 2006, The Lancet Neurology.

[38]  Jennifer L. Etnier,et al.  A meta-regression to examine the relationship between aerobic fitness and cognitive performance , 2006, Brain Research Reviews.

[39]  P. Zandi,et al.  Vascular Risk Factors for Incident Alzheimer Disease and Vascular Dementia: The Cache County Study , 2006, Alzheimer disease and associated disorders.

[40]  J. Williamson,et al.  Cognitive decline and dementia in diabetes—systematic overview of prospective observational studies , 2005, Diabetologia.

[41]  L S Honig,et al.  Aggregation of vascular risk factors and risk of incident Alzheimer disease , 2005, Neurology.

[42]  F. Hu,et al.  Plasma C peptide level and cognitive function among older women without diabetes mellitus. , 2005, Archives of internal medicine.

[43]  C. Pieper,et al.  Identification of VaD and AD prodromes: The Cache County Study , 2005, Alzheimer's & Dementia.

[44]  Lisa M LaVange,et al.  Randomization-based nonparametric methods for the analysis of multicentre trials , 2005, Statistical methods in medical research.

[45]  J. Cummings,et al.  The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment , 2005, Journal of the American Geriatrics Society.

[46]  K Yaffe,et al.  Midlife cardiovascular risk factors and risk of dementia in late life , 2005, Neurology.

[47]  E. Reiman,et al.  Vascular risk factors, incidence of MCI, and rates of progression to dementia , 2004, Neurology.

[48]  R. Mayeux,et al.  Dietary factors and Alzheimer's disease , 2004, The Lancet Neurology.

[49]  K. Ottenbacher,et al.  The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis. , 2004, Archives of physical medicine and rehabilitation.

[50]  R. Marfella,et al.  Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. , 2004, JAMA.

[51]  J. Manson,et al.  Physical activity, including walking, and cognitive function in older women. , 2004, JAMA.

[52]  C. Jack,et al.  Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment , 2004, Journal of internal medicine.

[53]  D. Bennett,et al.  Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. , 2004, Archives of neurology.

[54]  Peter P. Zandi,et al.  Apolipoprotein E ϵ4 Count Affects Age at Onset of Alzheimer Disease,but Not Lifetime Susceptibility: The Cache County Study , 2004 .

[55]  Eric J Topol,et al.  Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins , 2004, The Lancet.

[56]  M. Haan,et al.  Can dementia be prevented? Brain aging in a population-based context. , 2004, Annual review of public health.

[57]  J. C. Torre.  Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics , 2004, The Lancet Neurology.

[58]  L. Leach,et al.  Diagnostic utility of abbreviated fluency measures in Alzheimer disease and vascular dementia , 2004, Neurology.

[59]  L. Fried,et al.  Cognitive Impairment and Decline Are Associated with Carotid Artery Disease in Patients without Clinically Evident Cerebrovascular Disease , 2004, Annals of Internal Medicine.

[60]  Daniel W. Jones,et al.  Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. , 2003, Hypertension.

[61]  R. Malouf,et al.  Vitamin B6 for cognition , 2003 .

[62]  Antonio Colombo,et al.  From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II. , 2003, Circulation.

[63]  E. Boerwinkle,et al.  From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. , 2003, Circulation.

[64]  A. Ignaszewski,et al.  The prognostic importance of endothelial dysfunction and carotid atheroma burden in patients with coronary artery disease. , 2003, Journal of the American College of Cardiology.

[65]  R. Malouf,et al.  Vitamin B12 for cognition. , 2003, The Cochrane database of systematic reviews.

[66]  S. Rubin,et al.  Inflammatory markers and cognition in well-functioning African-American and white elders , 2003, Neurology.

[67]  D. Bennett,et al.  Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. , 2003, Archives of neurology.

[68]  Michael T. Watkins,et al.  Predictive value of noninvasivelydetermined endothelial dysfunction for long-term cardiovascular events inpatients with peripheral vascular disease , 2003 .

[69]  A. Hofman,et al.  Silent brain infarcts and the risk of dementia and cognitive decline. , 2003, The New England journal of medicine.

[70]  G. Maurer,et al.  Noninvasive ultrasound techniques for the assessment of atherosclerosis in coronary artery disease. , 2003, Circulation journal : official journal of the Japanese Circulation Society.

[71]  Amir Lerman,et al.  Endothelial Dysfunction: A Marker of Atherosclerotic Risk , 2003, Arteriosclerosis, thrombosis, and vascular biology.

[72]  D. Bennett,et al.  Dietary fats and the risk of incident Alzheimer disease. , 2003, Archives of neurology.

[73]  G. Balady,et al.  Effect of exercise on upper and lower extremity endothelial function in patients with coronary artery disease. , 2002, The American journal of cardiology.

[74]  A. Hofman,et al.  Dietary Intake of Antioxidants and Risk of Alzheimer Disease , 2002 .

[75]  S. West,et al.  A comparison of methods to test mediation and other intervening variable effects. , 2002, Psychological methods.

[76]  Kenneth Rockwood,et al.  Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people. , 2002, Archives of neurology.

[77]  E. Benjamin,et al.  Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. , 2002, Journal of the American College of Cardiology.

[78]  T. Meinertz,et al.  Endothelial Dysfunction, Oxidative Stress, and Risk of Cardiovascular Events in Patients With Coronary Artery Disease , 2001, Circulation.

[79]  K Yaffe,et al.  A prospective study of physical activity and cognitive decline in elderly women: women who walk. , 2001, Archives of internal medicine.

[80]  B. Winblad,et al.  Vitamin B12 and folate in relation to the development of Alzheimer’s disease , 2001, Neurology.

[81]  C. Schweiger.  [Statins and the risk of dementia]. , 2001, Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology.

[82]  R. Costa,et al.  Incidence of AD in African-Americans, Caribbean Hispanics, and Caucasians in northern Manhattan , 2001, Neurology.

[83]  K. Kostner,et al.  Late prognostic value of flow-mediated dilation in the brachial artery of patients with chest pain. , 2000, The American journal of cardiology.

[84]  M. Breteler.  Vascular Involvement in Cognitive Decline and Dementia: Epidemiologic Evidence from the Rotterdam Study and the Rotterdam Scan Study , 2000, Annals of the New York Academy of Sciences.

[85]  R. Havlik,et al.  Midlife blood pressure and dementia: the Honolulu–Asia aging study☆ , 2000, Neurobiology of Aging.

[86]  E. Tangalos,et al.  Fear recognition deficits after focal brain damage , 2000, Neurology.

[87]  R. Stewart,et al.  Vascular Risk Factors and Alzheimer's Disease , 1999, The Australian and New Zealand journal of psychiatry.

[88]  W. Jagust,et al.  The Role of APOE ∊4 in Modulating Effects of Other Risk Factors for Cognitive Decline in Elderly Persons , 1999 .

[89]  E. Tangalos,et al.  Mild Cognitive Impairment Clinical Characterization and Outcome , 1999 .

[90]  L. Appel,et al.  Effects of dietary patterns on blood pressure: subgroup analysis of the Dietary Approaches to Stop Hypertension (DASH) randomized clinical trial. , 1999, Archives of internal medicine.

[91]  R Clarke,et al.  Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. , 1998, Archives of neurology.

[92]  L. Fried,et al.  Relationship between ApoE, MRI findings, and cognitive function in the Cardiovascular Health Study. , 1998, Stroke.

[93]  L S Honig,et al.  Aging and Alzheimer's disease: lessons from the Nun Study. , 1998, The Gerontologist.

[94]  Jennifer L. Etnier,et al.  The Influence of Physical Fitness and Exercise upon Cognitive Functioning: A Meta-Analysis , 1997 .

[95]  D. Melzer,et al.  Cognitive impairment in elderly people: population based estimate of the future in England, Scotland, and Wales , 1997, BMJ.

[96]  Alistair Burns,et al.  Observations on the brains of demented old people. B.E. Tomlinson, G. Blessed and M. Roth, Journal of the Neurological Sciences (1970) 11, 205–242; (1968) 7, 331–356 , 1997 .

[97]  Janice E Graham,et al.  Prevalence and severity of cognitive impairment with and without dementia in an elderly population , 1997, The Lancet.

[98]  A. Hofman,et al.  Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study , 1997, The Lancet.

[99]  P. Touboul,et al.  Ultrasonographic assessment of carotid wall characteristics and cognitive functions in a community sample of 59- to 71-year-olds. The EVA Study Group. , 1996, Stroke.

[100]  B. Pannier,et al.  Assessment of arterial distensibility by automatic pulse wave velocity measurement. Validation and clinical application studies. , 1995, Hypertension.

[101]  P. Ganz,et al.  Systemic nature of endothelial dysfunction in atherosclerosis. , 1995, The American journal of cardiology.

[102]  J. J. Claus,et al.  Cardiovascular disease and distribution of cognitive function in elderly people: the Rotterdam study , 1994, BMJ.

[103]  J. K. Lloyd,et al.  Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis , 1992, The Lancet.

[104]  G Wassmer,et al.  Procedures for two-sample comparisons with multiple endpoints controlling the experimentwise error rate. , 1991, Biometrics.

[105]  R B D'Agostino,et al.  Probability of stroke: a risk profile from the Framingham Study. , 1991, Stroke.

[106]  M. D. O'Brien,et al.  Cerebral blood flow in dementia , 1986, Neurology.

[107]  P. O'Brien.  Procedures for comparing samples with multiple endpoints. , 1984, Biometrics.

[108]  R. B. Johnson,et al.  Effects of frequency and duration of training on attrition and incidence of injury. , 1976, Medicine and science in sports.

[109]  Glen E Duncan,et al.  Effects of aerobic exercise on mild cognitive impairment: a controlled trial. , 2010, Archives of neurology.

[110]  D. Steffens,et al.  Textbook of Geriatric Psychiatry , 2009 .

[111]  D. Grobbee,et al.  Cardiovascular disease and cognitive performance in middle-aged and elderly men. , 2007, Atherosclerosis.

[112]  Benjamin J. Epstein,et al.  Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure , 2007 .

[113]  J. Wands,et al.  Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes? , 2005, Journal of Alzheimer's disease : JAD.

[114]  Deborah Gustafson,et al.  Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. , 2004, Archives of neurology.

[115]  T. Harris,et al.  The metabolic syndrome, inflammation, and risk of cognitive decline. , 2004, JAMA.

[116]  J. C. de la Torre,et al.  For Personal Use. Only Reproduce with Permission the Lancet Publishing Group. Personal View Is Ad Neurodegenerative or Vascular? Is Ad Neurodegenerative? Is Alzheimer's Disease a Neurodegenerative or a Vascular Disorder? Data, Dogma, and Dialectics , 2022 .

[117]  J. Grimley Evans,et al.  The effect of vitamin B6 on cognition. , 2003, The Cochrane database of systematic reviews.

[118]  M. Watkins,et al.  Predictive value of noninvasively determined endothelial dysfunction for long-term cardiovascular events in patients with peripheral vascular disease. , 2003, Journal of the American College of Cardiology.

[119]  M. Essink‐bot,et al.  Cross-national comparability of burden of disease estimates: the European Disability Weights Project. , 2002, Bulletin of the World Health Organization.

[120]  B. Winblad,et al.  Vitamin B12 and folate in relation to the development of Alzheimer’s disease , 2001, Neurology.

[121]  H. Sinzinger,et al.  Endothelial dysfunction, atherosclerosis and diabetes. , 1999, Acta medica Austriaca.

[122]  W. Jagust,et al.  The role of APOE epsilon4 in modulating effects of other risk factors for cognitive decline in elderly persons. , 1999, JAMA.

[123]  M L Bots,et al.  Apolipoprotein E genotype, atherosclerosis, and cognitive decline: the Rotterdam Study. , 1998, Journal of neural transmission. Supplementum.

[124]  E. Feskens,et al.  Polyunsaturated fatty acids, antioxidants, and cognitive function in very old men. , 1997, American journal of epidemiology.

[125]  C. Klersy,et al.  Different methods to analyze clinical experiments with multiple endpoints: a comparison of real data. , 1996, Journal of biopharmaceutical statistics.

[126]  R B D'Agostino,et al.  Stroke risk profile: adjustment for antihypertensive medication. The Framingham Study. , 1994, Stroke.

[127]  D. A. Kenny,et al.  The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. , 1986, Journal of personality and social psychology.