Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates.
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J. Cianfrogna | A. Stepan | Daniel P. Walker | L. Chen | K. Zasadny | P. Verhoest | Patrick E. Trapa | M. Moen | G. Cappon | Xinjun Hou | K. Karki | D. Smith | J. Mancuso | C. L. Shaffer | M. Reese | M. Skaddan | J. R. Dunetz | S. Drozda | Lei Zhang | G. Barreiro | J. Whritenour | K. Coffman | C. Houle | L. Chenard | J. Lazzaro | J. Marcek | J. Tuttle | M. Bohanon | V. Parikh | Somraj Ghosh | M. Zaleska | Isao Sakurada | E. Miller | B. Boscoe | Jason Barricklow | A. Won | A. S. Wright | M. M. Claffey | G. Balan | S. O'neil