The Potential Impact of Pre-Exposure Prophylaxis for HIV Prevention among Men Who Have Sex with Men and Transwomen in Lima, Peru: A Mathematical Modelling Study

Gabriela Gomez and colleagues developed a mathematical model of the HIV epidemic among men who have sex with men and transwomen in Lima, Peru to explore whether HIV pre-exposure prophylaxis could be a cost-effective addition to existing HIV prevention strategies.

[1]  Katrien Fransen,et al.  Preexposure prophylaxis for HIV infection among African women. , 2012, The New England journal of medicine.

[2]  John T Brooks,et al.  Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana. , 2012, The New England journal of medicine.

[3]  James D. Campbell,et al.  Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. , 2012, The New England journal of medicine.

[4]  L. Myer,et al.  Southern African guidelines for the safe use of pre-exposure prophylaxis in men who have sex with men who are at risk for HIV infection : guidelines , 2012 .

[5]  W. Mcfarland,et al.  Understanding the HIV/AIDS Epidemic in Transgender Women of Lima, Peru: Results from a Sero-Epidemiologic Study Using Respondent Driven Sampling , 2012, AIDS and Behavior.

[6]  M. Brandeau,et al.  The Cost-Effectiveness of Preexposure Prophylaxis for HIV Prevention in the United States in Men Who Have Sex With Men , 2012, Annals of Internal Medicine.

[7]  S. McCormack,et al.  The British HIV Association/British Association for Sexual Health and HIV Position Statement on pre-exposure prophylaxis in the UK , 2012, International journal of STD & AIDS.

[8]  J. Baeten,et al.  Optimal Uses of Antiretrovirals for Prevention in HIV-1 Serodiscordant Heterosexual Couples in South Africa: A Modelling Study , 2011, PLoS medicine.

[9]  Stephen W. Sorensen,et al.  The cost-effectiveness of pre-exposure prophylaxis in men who have sex with men in the United States: an epidemic model. , 2011, Journal of Acquired Immune Deficiency Syndromes.

[10]  C. Ávila-Figueroa,et al.  Levels of Spending and Resource Allocation to HIV Programs and Services in Latin America and the Caribbean , 2011, PloS one.

[11]  J. Stover HIV models to inform health policy. , 2011, Current opinion in HIV and AIDS.

[12]  A. Lansky,et al.  Interim guidance: preexposure prophylaxis for the prevention of HIV infection in men who have sex with men. , 2011, MMWR. Morbidity and mortality weekly report.

[13]  David V Glidden,et al.  Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. , 2010, The New England journal of medicine.

[14]  K. Stanecki,et al.  Estimating the impact of antiretroviral therapy: regional and global estimates of life-years gained among adults , 2010, Sexually Transmitted Infections.

[15]  Carel Pretorius,et al.  Evaluating the Cost-Effectiveness of Pre-Exposure Prophylaxis (PrEP) and Its Impact on HIV-1 Transmission in South Africa , 2010, PloS one.

[16]  Lynn Morris,et al.  Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women , 2010, Science.

[17]  T. Hallett,et al.  HIV and risk environment for injecting drug users: the past, present, and future , 2010, The Lancet.

[18]  Sally Blower,et al.  HIV, transmitted drug resistance, and the paradox of preexposure prophylaxis , 2010, Proceedings of the National Academy of Sciences.

[19]  Connie Celum,et al.  Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis , 2010, The Lancet.

[20]  Marie-Claude Boily,et al.  HIV transmission risk through anal intercourse: systematic review, meta-analysis and implications for HIV prevention , 2010, International journal of epidemiology.

[21]  C. Beyrer,et al.  The expanding epidemics of HIV type 1 among men who have sex with men in low- and middle-income countries: diversity and consistency. , 2010, Epidemiologic reviews.

[22]  David Iglesias,et al.  Determining a cost effective intervention response to HIV/AIDS in Peru , 2009, BMC public health.

[23]  K. Russell,et al.  High HIV and Ulcerative Sexually Transmitted Infection Incidence Estimates Among Men Who Have Sex With Men in Peru: Awaiting for an Effective Preventive Intervention , 2009, Journal of acquired immune deficiency syndromes.

[24]  R. Walensky,et al.  HIV preexposure prophylaxis in the United States: impact on lifetime infection risk, clinical outcomes, and cost-effectiveness. , 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[25]  Kelika A. Konda,et al.  Risk factors for the spread of HIV and other sexually transmitted infections among men who have sex with men infected with HIV in Lima, Peru , 2008, Sexually Transmitted Infections.

[26]  G. Garnett,et al.  Modeling the impact of HIV chemoprophylaxis strategies among men who have sex with men in the United States: HIV infections prevented and cost-effectiveness , 2008, AIDS.

[27]  Christophe Fraser,et al.  HIV-1 transmission, by stage of infection. , 2008, The Journal of infectious diseases.

[28]  Eddy R. Segura,et al.  Epidemiology of male same-sex behaviour and associated sexual health indicators in low- and middle-income countries: 2003–2007 estimates , 2008, Sexually Transmitted Infections.

[29]  Kelika A. Konda,et al.  New Populations at High Risk of HIV/STIs in Low-income, Urban Coastal Peru , 2008, AIDS and Behavior.

[30]  Laith J. Abu-Raddad,et al.  Understanding the Impact of Male Circumcision Interventions on the Spread of HIV in Southern Africa , 2008, PLoS ONE.

[31]  David Iglesias,et al.  Predictors of CD4+ cell count response and of adverse outcome among HIV-infected patients receiving highly active antiretroviral therapy in a public hospital in Peru. , 2008, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

[32]  J. Klausner,et al.  High Rates of Sex with Men among High-Risk, Heterosexually-Identified Men in Low-Income, Coastal Peru , 2008, AIDS and Behavior.

[33]  Roy M. Anderson,et al.  Potential Impact of Antiretroviral Chemoprophylaxis on HIV-1 Transmission in Resource-Limited Settings , 2007, PloS one.

[34]  Kelika A. Konda,et al.  Prevalence of Same-Sex Sexual Behavior and Associated Characteristics among Low-Income Urban Males in Peru , 2007, PloS one.

[35]  Adrian E. Raftery,et al.  Probabilistic projections of HIV prevalence using Bayesian melding. , 2007, 0709.0421.

[36]  J. Hughes,et al.  HIV-1, Sexually Transmitted Infections, and Sexual Behavior Trends Among Men Who Have Sex With Men in Lima, Peru , 2007, Journal of acquired immune deficiency syndromes.

[37]  J. Kublin,et al.  Dual Infection with HIV and Malaria Fuels the Spread of Both Diseases in Sub-Saharan Africa , 2006, Science.

[38]  J. Carr,et al.  Association of herpes simplex virus type 2 infection and syphilis with human immunodeficiency virus infection among men who have sex with men in Peru. , 2006, The Journal of infectious diseases.

[39]  K. Konda,et al.  Estimating the number of men who have sex with men in low and middle income countries , 2006, Sexually Transmitted Infections.

[40]  Neil M Ferguson,et al.  Modelling the Impact of Antiretroviral Use in Resource-Poor Settings , 2006, PLoS medicine.

[41]  J. Salomon,et al.  The Global Impact of Scaling Up HIV/AIDS Prevention Programs in Low- and Middle-Income Countries , 2006, Science.

[42]  G. Sánchez,et al.  Prevalences, Genotypes, and Risk Factors for HIV Transmission in South America , 2005, Journal of acquired immune deficiency syndromes.

[43]  S. Goodreau,et al.  Sexual role and transmission of HIV Type 1 among men who have sex with men, in Peru. , 2005, The Journal of infectious diseases.

[44]  A. Rothberg Making Choices in Health: WHO Guide to Cost Effectiveness Analysis , 2008 .

[45]  W. Mendoza,et al.  Clients of Female Sex Workers in Lima, Peru: A Bridge Population for Sexually Transmitted Disease/HIV Transmission? , 2004, Sexually transmitted diseases.

[46]  N. Walker,et al.  Status of the HIV/AIDS epidemic and methods to monitor it in the Latin America and Caribbean region , 2002, AIDS.

[47]  Else Smith [Condom effectiveness in reducing heterosexual HIV transmission]. , 2002, Ugeskrift for laeger.

[48]  Jonathan AC Sterne,et al.  Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies , 2002, The Lancet.

[49]  K. Holmes,et al.  HIV, syphilis and heterosexual bridging among Peruvian men who have sex with men , 2002, AIDS.

[50]  J. Fox-Rushby,et al.  Calculating and presenting disability adjusted life years (DALYs) in cost-effectiveness analysis. , 2001, Health policy and planning.

[51]  A. Raftery,et al.  Inference for Deterministic Simulation Models: The Bayesian Melding Approach , 2000 .

[52]  J. Shelton,et al.  Empirically Based Conversion Factors for Calculating Couple-Years of Protection , 2000, Evaluation review.

[53]  E. Vittinghoff,et al.  Per-contact risk of human immunodeficiency virus transmission between male sexual partners. , 1999, American journal of epidemiology.

[54]  S. Pinkerton,et al.  Effectiveness of condoms in preventing HIV transmission. , 1997, Social science & medicine.

[55]  K. Hyams,et al.  The epidemiology of HIV‐1 infection in Peru, 1986–1990 , 1996, AIDS.

[56]  Hadi Dowlatabadi,et al.  Sensitivity and Uncertainty Analysis of Complex Models of Disease Transmission: an HIV Model, as an Example , 1994 .

[57]  E. Gotuzzo,et al.  Acquired immunodeficiency syndrome in Peru. , 1986, Annals of internal medicine.

[58]  A. Mills,et al.  Cost Effectiveness in Low- and Middle-Income Countries , 2012, PharmacoEconomics.

[59]  Nikhil Dutta,et al.  Global Fund To Fight AIDS, Tuberculosis, And Malaria , 2010 .

[60]  A. Alban Costing guidelines for HIV/AIDS intervention strategies : for use in estimating resource needs, scaling-up and strategic planning in the Asia/Pacific region , 2004 .

[61]  E. Gotuzzo,et al.  Sexual behavior and frequency of antibodies to type 1 human immunodeficiency virus (HIV-1) in a group of Peruvian male homosexuals. , 1991, Bulletin of the Pan American Health Organization.