IRAK-4 deficiency as a cause for familial fatal invasive infection by Streptococcus pneumoniae.

[1]  N Baldwin,et al.  A narrow repertoire of transcriptional modules responsive to pyogenic bacteria is impaired in patients carrying loss-of-function mutations in MYD88 or IRAK4 , 2014, Nature Immunology.

[2]  J. Casanova,et al.  Invasive pneumococcal disease in children can reveal a primary immunodeficiency. , 2014, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[3]  J. Casanova,et al.  Infectious Diseases in Patients with IRAK-4, MyD88, NEMO, or IκBα Deficiency , 2011, Clinical Microbiology Reviews.

[4]  Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency , 2011, Pediatrics.

[5]  Steven M. Holland,et al.  Primary Immunodeficiency Diseases: an Update on the Classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency 2015 , 2009, Front. Immun..

[6]  Douglas R. McDonald,et al.  Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity , 2007, The Journal of experimental medicine.

[7]  J. Orange,et al.  Prevalence of Toll-like receptor signalling defects in apparently healthy children who developed invasive pneumococcal infection. , 2007, Clinical immunology.

[8]  J. Casanova,et al.  IRAK-4 Mutation (Q293X): Rapid Detection and Characterization of Defective Post-Transcriptional TLR/IL-1R Responses in Human Myeloid and Non-Myeloid Cells1 , 2006, The Journal of Immunology.

[9]  J. Banchereau,et al.  Pyogenic Bacterial Infections in Humans with MyD88 Deficiency , 2003, Science.