Initial Experience of 3 Tesla Endorectal Coil Magnetic Resonance Imaging and 1H-Spectroscopic Imaging of the Prostate

Rationale and Objectives:We sought to explore the feasibility of magnetic resonance imaging (MRI) of the prostate at 3T, with the knowledge of potential drawbacks of MRI at high field strengths. Material and Methods:MRI, dynamic MRI, and 1H-MR spectroscopic imaging were performed in 10 patients with prostate cancer on 1.5T and 3T whole-body scanners. Comparable scan protocols were used, and additional high-resolution measurements at 3T were acquired. For both field strengths the signal-to-noise ratio was calculated and image quality was assessed. Results:At 3T the signal-to-noise ratio improved. This resulted in increased spatial MRI resolution, which significantly improved anatomic detail. The increased spectral resolution improved the separation of individual resonances in MRSI. Contrast-enhanced time-concentration curves could be obtained with a doubled temporal resolution. Conclusions:Initial results of endorectal 3T 1H-MR spectroscopic imaging in prostate cancer patients showed potential advantages: the increase in spatial, temporal, and spectral resolution at higher field strength may result in an improved accuracy in delineating and staging prostate cancer.

[1]  P. Carroll,et al.  Three-dimensional H-1 MR spectroscopic imaging of the in situ human prostate with high (0.24-0.7-cm3) spatial resolution. , 1996, Radiology.

[2]  René M. Botnar,et al.  Preliminary report on in vivo coronary MRA at 3 Tesla in humans , 2002, Magnetic resonance in medicine.

[3]  C. Matula,et al.  Magnetic Resonance Imaging Contrast Enhancement of Brain Tumors at 3 Tesla Versus 1.5 Tesla , 2002, Investigative radiology.

[4]  J. Kurhanewicz,et al.  Improved water and lipid suppression for 3D PRESS CSI using rf band selective inversion with gradient dephasing (basing) , 1997, Magnetic resonance in medicine.

[5]  M. van der Graaf,et al.  Human prostate: multisection proton MR spectroscopic imaging with a single spin-echo sequence--preliminary experience. , 1999, Radiology.

[6]  T. Foster,et al.  A review of normal tissue hydrogen NMR relaxation times and relaxation mechanisms from 1-100 MHz: dependence on tissue type, NMR frequency, temperature, species, excision, and age. , 1984, Medical physics.

[7]  Henkjan J Huisman,et al.  Discrimination of prostate cancer from normal peripheral zone and central gland tissue by using dynamic contrast-enhanced MR imaging. , 2003, Radiology.

[8]  A. Kangarlu,et al.  Ultra high resolution imaging of the human head at 8 tesla: 2K x 2K for Y2K. , 2000, Journal of computer assisted tomography.

[9]  M. Gorassini,et al.  In vivo magnetic resonance imaging of the human cervical spinal cord at 3 Tesla , 2002, Journal of magnetic resonance imaging : JMRI.

[10]  M. van der Graaf,et al.  In vivo proton MR spectroscopy reveals altered metabolite content in malignant prostate tissue. , 1997, Anticancer research.

[11]  J Kurhanewicz,et al.  Citrate as an in vivo marker to discriminate prostate cancer from benign prostatic hyperplasia and normal prostate peripheral zone: detection via localized proton spectroscopy. , 1995, Urology.

[12]  P S Tofts,et al.  Quantitative Analysis of Dynamic Gd‐DTPA Enhancement in Breast Tumors Using a Permeability Model , 1995, Magnetic resonance in medicine.

[13]  Gabriel P. Krestin,et al.  Contrast‐Enhanced Endorectal Coil MRI in Local Staging of Prostate Carcinoma , 1995, Journal of computer assisted tomography.

[14]  C. Tempany,et al.  Invasion of the neurovascular bundle by prostate cancer: evaluation with MR imaging. , 1991, Radiology.

[15]  Hee-Won Kim,et al.  In Vivo Prostate Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy at 3 Tesla Using a Transceive Pelvic Phased Array Coil: Preliminary Results , 2003, Investigative radiology.

[16]  J R Thornbury,et al.  Local staging of prostate cancer with endorectal MR imaging: correlation with histopathology. , 1996, AJR. American journal of roentgenology.

[17]  Jacob Sosna,et al.  Determinations of prostate volume at 3-Tesla using an external phased array coil: comparison to pathologic specimens. , 2003, Academic radiology.

[18]  Arend Heerschap,et al.  Fast acquisition‐weighted three‐dimensional proton MR spectroscopic imaging of the human prostate , 2004, Magnetic resonance in medicine.

[19]  H. Huisman,et al.  Accurate estimation of pharmacokinetic contrast‐enhanced dynamic MRI parameters of the prostate , 2001, Journal of magnetic resonance imaging : JMRI.

[20]  D P Dearnaley,et al.  Dynamic contrast enhanced MRI of prostate cancer: correlation with morphology and tumour stage, histological grade and PSA. , 2000, Clinical radiology.

[21]  J. R. Landis,et al.  The measurement of observer agreement for categorical data. , 1977, Biometrics.

[22]  B R Rosen,et al.  Dynamic Gd‐DTPA enhanced MRI measurement of tissue cell volume fraction , 1995, Magnetic resonance in medicine.

[23]  Silvia D. Chang,et al.  Prostate cancer tumor volume: measurement with endorectal MR and MR spectroscopic imaging. , 2002, Radiology.

[24]  A. Georgopoulos,et al.  Functional mapping in the human brain using high magnetic fields. , 1999, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[25]  M Recht,et al.  Method for the quantitative assessment of contrast agent uptake in dynamic contrast‐enhanced MRI , 1994, Magnetic resonance in medicine.

[26]  J. V. van Engelshoven,et al.  Contrast‐enhanced peripheral MR angiography at 3.0 Tesla: Initial experience with a whole‐body scanner in healthy volunteers , 2003, Journal of magnetic resonance imaging : JMRI.

[27]  P. Carroll,et al.  Prostate cancer: localization with three-dimensional proton MR spectroscopic imaging--clinicopathologic study. , 1999, Radiology.