The future of image processing and CAD in diagnostic radiology is more promising now than ever, with increasingly impressive results being reported from various observer performance studies in both mammography and chest radiography. Clinical trials in years to come will help optimize the accuracy of the programs and determine the actual contribution of CAD to the interpretation process. Radiologists using output from computer analyses of images, however, will still make the final decision regarding diagnosis and patient management. Nonetheless, studies have indicated that the computer output need not have greater overall accuracy than a given radiologist in order to improve his or her performance. A systematic and gradual introduction of CAD into radiology departments will be necessary so that radiologists can become familiar with the strengths and weaknesses of each CAD program, thereby avoiding either excessive reliance or a dismissive attitude toward the computer output. This should ensure the acceptance of CAD and optimal diagnostic performance by the radiologist. Thus, an appropriate role for each CAD program will be determined for each radiologist, according to his or her individual training and observational skills, reducing intraobserver variations and improving diagnostic performance.