Prescription pattern of traditional Chinese medicine for climacteric women in Taiwan

Background Traditional Chinese medicine (TCM) has become more popular as a therapy for symptom relief among menopause-aged women. The aim of this study was to analyze the utilization of TCM for climacteric women in Taiwan. Methods The study analyzed frequency distributions among 19 379 women aged 45–55 years, recruited from a random-sampled cohort of 200 000 people from the National Health Insurance database. Data mining was conducted to explore the co-prescription patterns for finished herbal products (FHP). Result There were 19 379 women aged 45–55 years in the sample; of these, 12 572 (64.9%) utilized TCM services at least once. A total of 4078 (21.0%) of the 19 379 climacteric women utilized 145 200 (79.2%) TCM visits. Of these, 39 802 (21.7%) visits were because of diseases of the musculoskeletal system and connective tissue, of which more than half were treated with acupuncture and traumatology manipulative therapies. There were 28 154 visits with FHP prescriptions because of non-specific symptoms and ill-defined conditions, and Jia-wei-xiao-yao-san was the most frequent formula. Nearly two-thirds of FHP contained more than two herbal formulae. Conclusions Women of climacteric age in Taiwan utilized TCM more often than other age groups. To deal with multiple symptoms and/or diseases among climacteric women, new prescription patterns of combining two or more herbal formulae have evolved. Studies on safety issues and drug–herb interactions are warranted for future research.

[1]  Pau-Chung Chen,et al.  Development of active safety surveillance system for traditional Chinese medicine: an empirical study in treating climacteric women , 2006, Pharmacoepidemiology and drug safety.

[2]  Jing-Shiang Hwang,et al.  Duhuo Jisheng Tang for treating osteoarthritis of the knee: a prospective clinical observation , 2007, Chinese medicine.

[3]  Tzeng-Ji Chen,et al.  Use frequency of traditional Chinese medicine in Taiwan , 2007, BMC Health Services Research.

[4]  S. Mckinlay.  The normal menopause transition: an overview. , 1996, Maturitas.

[5]  R. Bauer,et al.  Use of traditional drugs in a hospital of Chinese medicine in Germany , 1999, Pharmacoepidemiology and drug safety.

[6]  H. Burger,et al.  Hormonal changes and biomarkers in late reproductive age, menopausal transition and menopause. , 2009, Best practice & research. Clinical obstetrics & gynaecology.

[7]  Thomas J. Schnitzer,et al.  Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update , 2000 .

[8]  M. Verhoef,et al.  Women's needs for CAM information to manage menopausal symptoms , 2007, Climacteric.

[9]  M. Tramèr,et al.  Quantitative estimation of rare adverse events which follow a biological progression: a new model applied to chronic NSAID use , 2000, Pain.

[10]  K. Yen,et al.  A pilot study comparing the clinical effects of Jia-Wey Shiau-Yau San, a traditional Chinese herbal prescription, and a continuous combined hormone replacement therapy in postmenopausal women with climacteric symptoms. , 2003, Maturitas.

[11]  J. Manson,et al.  Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause. , 2007, JAMA.

[12]  J P Kassirer,et al.  Alternative medicine--the risks of untested and unregulated remedies. , 1998, The New England journal of medicine.

[13]  P. Potthoff,et al.  The Menopause Rating Scale (MRS): comparison with Kupperman index and quality-of-life scale SF-36 , 2000, Climacteric : the journal of the International Menopause Society.

[14]  J. Hammitt,et al.  National Health Insurance and precautionary saving: evidence from Taiwan , 2003 .

[15]  Chuan-Fang Lee,et al.  The prescribing of Chinese herbal products in Taiwan: a cross‐sectional analysis of the national health insurance reimbursement database , 2008, Pharmacoepidemiology and drug safety.

[16]  N. Keenan,et al.  Complementary and alternative medicine use among midlife women for reasons including menopause in the United States: 2002 , 2007, Menopause.

[17]  Jing-Shiang Hwang,et al.  Finished herbal product as an alternative treatment for menopausal symptoms in climacteric women. , 2005, Journal of alternative and complementary medicine.