Desmoid Type Fibromatosis of the Breast Masquerading as Breast Carcinoma: Value of Dynamic Magnetic Resonance Imaging and Its Correlation.

Desmoid type fibromatosis of the breast is a rare stromal tumor that accounts for <0.2% of all breast tumors. Bilateral and multicentric lesions are extremely rare, with only less than ten cases reported in the literature. Although benign, it is locally aggressive with frequent recurrence in up to almost one-third of the cases. We experienced our first case of bilateral multicentric breast fibromatosis in a 19-year-old woman, with a paternal aunt diagnosed with breast cancer at age 30, who presented to our institution with the chief complaint of retracted nipples for 1 year. The patient denied any history of trauma to her chest. Sonography showed suspicious bilateral hypoechoic masses. Magnetic resonance imaging (MRI) was performed for further evaluation because of the extensive involvement of both the breasts. This report aimed to illustrate the main clinical, radiological, and histopathological characteristics of this rare disease to increase awareness of this entity and discuss the role of MRI.

[1]  Susan Crook,et al.  Fibromatosis arising from the pectoralis major muscle mimicking breast cancer , 2018, Radiology case reports.

[2]  R. Lo Gullo,et al.  Fibromatosis of the breast mimicking cancer: A case report , 2017, Radiology case reports.

[3]  K. Pohlodek,et al.  Desmoid-type fibromatosis of the breast: A report of 2 cases , 2017, Oncology letters.

[4]  A. Somwangprasert,et al.  Bilateral desmoid tumor of the breast: case seriesand literature review , 2016, International medical case reports journal.

[5]  A. Flanagan,et al.  Next-generation sequencing is highly sensitive for the detection of beta-catenin mutations in desmoid-type fibromatoses , 2015, Virchows Archiv.

[6]  Katrina N Glazebrook,et al.  Mammary fibromatosis. , 2009, AJR. American journal of roentgenology.

[7]  H. Haro,et al.  Report of 2 cases , 2008 .

[8]  L. Anna,et al.  Desmoid Tumor of the Breast: Radiologic Appearance with a Focus on its Magnetic Resonance Features , 2008 .

[9]  C. Zuiani,et al.  Desmoid tumor of the breast: radiologic appearance with a focus on its magnetic resonance features. , 2008, The breast journal.

[10]  B. A. Buchele,et al.  Management of a patient with multiple recurrences of fibromatosis (desmoid tumor) of the breast involving the chest wall musculature , 2006, World journal of surgical oncology.

[11]  L. Fellah,et al.  Dynamic breast MRI in recurrent fibromatosis. , 2005, AJR. American journal of roentgenology.

[12]  P. Dempsey,et al.  Primary desmoid tumor (extraabdominal fibromatosis) of the breast. , 2005, AJR. American journal of roentgenology.

[13]  T. Nakazono,et al.  Dynamic MRI of fibromatosis of the breast. , 2003, AJR. American journal of roentgenology.

[14]  D. C. Henckel,et al.  Case report. , 1995, Journal.