Carcinogen Switching NQO1 Gene Polymorphism Study to Find Out the Risk Population in Vindhyan Region

The NQO1 is an important carcinogen metabolizing gene, as responsible for the metabolism of highly ubiquitous environmental carcinogen like Polycyclic Aromatic Hydrocarbon (PAH) which is also the most lethal constituent of cigarette smoke. The genotype and allelic frequencies of three Polycyclic aromatic Hydrocarbon (PAH) metabolizing genes were determined in a sample of typical population, which were stratified into three groups (Hindu, Muslim and Tribal) based on their ethnicity. DTdiphorase is an enzyme which has known because of its ability to detoxify a number of natural and Synthetic Compounds and also to activate certain anticancer factors [1]. Among Northern Europeans and Caucasian Americans, the gene frequency is 0.79 for the wild-type allele and 0.21 for the mutated allele [2,3]. DT-diphorase (NQO1) converts toxic benzoquinone into hydroquinone in an obligate two electron reduction [4].

[1]  T. Chakrabarti,et al.  Distribution of detoxifying genes polymorphism in Maharastrian population of central India. , 2008, Chemosphere.

[2]  Sang‐wook Lee,et al.  Association of the GSTP1 and NQO1 Polymorphisms and Head and Neck Squamous Cell Carcinoma Risk , 2006, Journal of Korean medical science.

[3]  D. Ross,et al.  A NAD(P)H:Quinone Oxidoreductase 1 Polymorphism Is a Risk Factor for Human Colon Cancer , 2006, Cancer Epidemiology Biomarkers & Prevention.

[4]  K. Cherian,et al.  Genetic polymorphism analysis of NAD ( P ) H : quinone oxidoreductase 1 in different Iranian ethnic groups , 2006 .

[5]  Y. Nakanishi,et al.  NQO1, MPO, and the risk of lung cancer: A HuGE review , 2005, Genetics in Medicine.

[6]  X. Shu,et al.  Oral contraceptive use and breast cancer risk: modification by NAD(P)H:quinone oxoreductase (NQO1) genetic polymorphisms. , 2004, Cancer Epidemiology, Biomarkers and Prevention.

[7]  M. Warholm,et al.  Influence of CYP1A1, GSTM1, GSTT1, and NQO1 genotypes and cumulative smoking dose on lung cancer risk in a Swedish population. , 2004, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[8]  D. Toncheva,et al.  Identification of NQO1 and GSTs genotype frequencies in Bulgarian patients with Balkan endemic nephropathy. , 2004, Journal of nephrology.

[9]  X. Shu,et al.  Urinary isothiocyanate excretion, brassica consumption, and gene polymorphisms among women living in Shanghai, China. , 2003, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[10]  R. Hayes,et al.  CYP2E1 and NQO1 genotypes, smoking and bladder cancer. , 2003, Pharmacogenetics.

[11]  W. Schulz,et al.  Association of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism with esophageal squamous cell carcinoma in a German Caucasian and a northern Chinese population. , 2003, Carcinogenesis.

[12]  J. Lotem,et al.  NQO1 stabilizes p53 through a distinct pathway , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[13]  A. Jaiswal.  Regulation of genes encoding NAD(P)H:quinone oxidoreductases. , 2000, Free radical biology & medicine.

[14]  A. Dinkova-Kostova,et al.  Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen. , 2000, Free radical biology & medicine.

[15]  M. Smith,et al.  Benzene, NQO1, and genetic susceptibility to cancer. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[16]  L. Marchand,et al.  Association of the NAD(P)H:quinone oxidoreductase 609C-->T polymorphism with a decreased lung cancer risk. , 1999, Cancer research.

[17]  Kyungsoon Kim,et al.  Reduction of Nitrosoarene by Purified NAD(P)H-Quinone Oxidoreductase , 1999 .

[18]  T. Murphy,et al.  Activation of Endogenous Antioxidant Defenses in Neuronal Cells Prevents Free Radical‐Mediated Damage , 1998, Journal of neurochemistry.

[19]  M. Spitz,et al.  Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy. , 1997, British Journal of Cancer.

[20]  M. Spitz,et al.  Lung cancer in Mexican-Americans and African-Americans is associated with the wild-type genotype of the NAD(P)H: quinone oxidoreductase polymorphism. , 1997, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[21]  D. Ross,et al.  Characterization of a polymorphism in NAD(P)H: quinone oxidoreductase (DT-diaphorase). , 1997, British Journal of Cancer.

[22]  B. Kuehl,et al.  A polymorphism in NAD(P)H:quinone oxidoreductase (NQO1): relationship of a homozygous mutation at position 609 of the NQO1 cDNA to NQO1 activity. , 1996, British Journal of Cancer.

[23]  A. Jaiswal,et al.  Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin. , 1991, Biochemistry.

[24]  E. Cadenas,et al.  DT-diaphorase: purification, properties, and function. , 1990, Methods in enzymology.