Vitamin-D synthesis and metabolism after ultraviolet irradiation of normal and vitamin-D-deficient subjects.

THE beneficial effects of sunlight in the treatment and prevention of rickets and osteomalacia have been recognized for over 60 years.1 However, little is known about the sequential changes in the serum concentrations of vitamin D and its metabolites after a single exposure to sunlight. In an attempt to understand these events, we monitored changes in serum concentrations of vitamin D and its metabolites, 25-hydroxyvitamin D (25-OH-D) and 1,25-dihydroxyvitamin D (1,25-(OH)2-D), over a three-week period in normal subjects and vitamin-D-deficient patients, before and after whole-body exposure to various doses of ultraviolet radiation (UVR). We found that exposure to . . .

[1]  J. Habener,et al.  Parathyroid Hormone in Human Plasma: IMMUNOCHEMICAL CHARACTERIZATION AND BIOLOGICAL IMPLICATIONS. , 1972, The Journal of clinical investigation.

[2]  H. DeLuca,et al.  Control of 25-hydroxycholecalciferol metabolism by parathyroid glands. , 1972, Proceedings of the National Academy of Sciences of the United States of America.

[3]  E. Mawer,et al.  The distribution and storage of vitamin D and its metabolites in human tissues. , 1972, Clinical science.

[4]  J. Round,et al.  Seasonal Changes in Human Plasma Levels of 25-Hydroxyvitamin D , 1974, Nature.

[5]  M. Preece,et al.  A competitive protein-binding assay for 25-hydroxycholecalciferol and 25-hydroxyergocalciferol in serum. , 1974, Clinica chimica acta; international journal of clinical chemistry.

[6]  T. Stamp.  Factors in human vitamin D nutrition and in the production and cure of classical rickets , 1975, Proceedings of the Nutrition Society.

[7]  H. DeLuca,et al.  A sensitive, precise, and convenient method for determination of 1,25-dihydroxyvitamin D in human plasma. , 1976, Archives of biochemistry and biophysics.

[8]  G. Jones.  Assay of vitamins D2 and D3, and 25-hydroxyvitamins D2 and D3 in human plasma by high-performance liquid chromatography. , 1978, Clinical chemistry.

[9]  T. Clemens,et al.  METABOLITES OF VITAMIN D IN HUMAN VITAMIN-D DEFICIENCY: EFFECT OF VITAMIN D3 OR 1,25-DIHYDROXYCHOLECALCIFEROL , 1980, The Lancet.

[10]  E. Mawer.  Clinical implications of measurements of circulating vitamin D metabolites. , 1980, Clinics in Endocrinology and Metabolism.

[11]  D. Lawson,et al.  Assessment of plasma 25-hydroxyvitamin D response to ultraviolet irradiation over a controlled area in young and elderly subjects. , 1980, Clinical science.

[12]  J. Adams,et al.  Silica Sep-Pak preparative chromatography for vitamin D and its metabolites. , 1981, Journal of chromatography.

[13]  H. DeLuca,et al.  Absence of seasonal variation in serum concentrations of 1,25-dihydroxyvitamin D despite a rise in 25-hydroxyvitamin D in summer. , 1981, The Journal of clinical endocrinology and metabolism.

[14]  M. Holick,et al.  The cutaneous photosynthesis of previtamin D3: a unique photoendocrine system. , 1981, The Journal of investigative dermatology.

[15]  R. Chesney,et al.  Seasonal fluctuations in serum concentrations of vitamin D metabolites in normal subjects. , 1981, British medical journal.