Impaired endothelial autophagy promotes liver fibrosis by aggravating the oxidative stress response during acute liver injury.

[1]  Y. Meng,et al.  Autophagic degradation of caveolin-1 promotes liver sinusoidal endothelial cells defenestration , 2018, Cell Death & Disease.

[2]  J. Wan,et al.  Macrophage autophagy protects against liver fibrosis in mice , 2015, Autophagy.

[3]  L. DeLeve Liver sinusoidal endothelial cells in hepatic fibrosis , 2015, Hepatology.

[4]  D. L. Le Couteur,et al.  A standardized method for the analysis of liver sinusoidal endothelial cells and their fenestrations by scanning electron microscopy. , 2015, Journal of visualized experiments : JoVE.

[5]  B. Rothermel,et al.  Autophagy in cardiovascular biology. , 2015, The Journal of clinical investigation.

[6]  G. Garcı́a-Cardeña,et al.  KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins , 2014, Gut.

[7]  C. Fondevila,et al.  A novel form of the human manganese superoxide dismutase protects rat and human livers undergoing ischaemia and reperfusion injury. , 2014, Clinical science.

[8]  F. Cecconi,et al.  Oxidative stress and autophagy: the clash between damage and metabolic needs , 2014, Cell Death and Differentiation.

[9]  Michael Simons,et al.  Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis , 2013, Nature.

[10]  In Hye Lee,et al.  Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor , 2013, Nature Medicine.

[11]  S. Werner,et al.  Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy. , 2013, Journal of hepatology.

[12]  J. Bosch,et al.  Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats. , 2013, Journal of hepatology.

[13]  J. Bosch,et al.  Recombinant human manganese superoxide dismutase reduces liver fibrosis and portal pressure in CCl4-cirrhotic rats. , 2013, Journal of hepatology.

[14]  S. Friedman,et al.  Reduced hepatic stellate cell expression of kruppel‐like factor 6 tumor suppressor isoforms amplifies fibrosis during acute and chronic rodent liver injury , 2013, Hepatology.

[15]  J. Bosch,et al.  Sinusoidal Endothelial Dysfunction Precedes Inflammation and Fibrosis in a Model of NAFLD , 2012, PloS one.

[16]  S. Friedman,et al.  Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues. , 2012, Gastroenterology.

[17]  G. Kanel,et al.  Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats. , 2012, Gastroenterology.

[18]  G. Karaca,et al.  Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation , 2012, Gut.

[19]  R. Bischoff,et al.  Antibody‐Free Detection of Protein Tyrosine Nitration in Tissue Sections , 2011, Chembiochem : a European journal of chemical biology.

[20]  Xiao-Ming Yin,et al.  Selective taste of ethanol-induced autophagy for mitochondria and lipid droplets , 2011, Autophagy.

[21]  G. Kroemer,et al.  Autophagy and the integrated stress response. , 2010, Molecular cell.

[22]  Zev Rosenwaks,et al.  Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration , 2010, Nature.

[23]  N. LaRusso,et al.  Immortalized liver endothelial cells: a cell culture model for studies of motility and angiogenesis , 2010, Laboratory Investigation.

[24]  S. Goerdt,et al.  Liver sinusoidal endothelium: A microenvironment‐dependent differentiation program in rat including the novel junctional protein liver endothelial differentiation‐associated protein‐1 , 2010, Hepatology.

[25]  B. Neuschwander‐Tetri,et al.  Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. , 2010, The New England journal of medicine.

[26]  Mihee M. Kim,et al.  The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 , 2010, Nature Cell Biology.

[27]  M. Czaja,et al.  Autophagy regulates adipose mass and differentiation in mice. , 2009, The Journal of clinical investigation.

[28]  Yongqiang Chen,et al.  Superoxide is the major reactive oxygen species regulating autophagy , 2009, Cell Death and Differentiation.

[29]  M. Czaja,et al.  Autophagy regulates lipid metabolism , 2009, Nature.

[30]  L. DeLeve,et al.  Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence , 2008, Hepatology.

[31]  Mercedes Fernandez,et al.  Increased oxidative stress in cirrhotic rat livers: A potential mechanism contributing to reduced nitric oxide bioavailability , 2007, Hepatology.

[32]  N. Mizushima,et al.  Autophagy: process and function. , 2007, Genes & development.

[33]  J. Bosch,et al.  Enhanced vasoconstrictor prostanoid production by sinusoidal endothelial cells increases portal perfusion pressure in cirrhotic rat livers. , 2007, Journal of hepatology.

[34]  Z. Elazar,et al.  Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4 , 2007, The EMBO journal.

[35]  Masaaki Komatsu,et al.  Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice , 2005, The Journal of cell biology.

[36]  R. McCuskey,et al.  Rat liver sinusoidal endothelial cell phenotype is maintained by paracrine and autocrine regulation. , 2004, American journal of physiology. Gastrointestinal and liver physiology.

[37]  P. Hayashi,et al.  Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis , 2003, American Journal of Gastroenterology.

[38]  P. J. Harvey,et al.  Pseudocapillarization and associated energy limitation in the aged rat liver , 2001, Hepatology.

[39]  D. Rockey,et al.  Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: endothelial dysfunction in portal hypertension. , 1998, Gastroenterology.

[40]  A. Cuervo,et al.  Activation of a selective pathway of lysosomal proteolysis in rat liver by prolonged starvation. , 1995, The American journal of physiology.

[41]  B. Schneider,et al.  Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver. , 1989, Journal of hepatology.

[42]  J. Bosch,et al.  Cross-talk between autophagy and KLF2 determines endothelial cell phenotype and microvascular function in acute liver injury. , 2017, Journal of hepatology.

[43]  Richard Moreau,et al.  Liver sinusoidal endothelial cells: Physiology and role in liver diseases. , 2017, Journal of hepatology.

[44]  M. Czaja,et al.  Macrophage autophagy limits acute toxic liver injury in mice through down regulation of interleukin-1β. , 2016, Journal of hepatology.

[45]  P. Auberger,et al.  When autophagy meets cancer through p62/SQSTM1. , 2012, American journal of cancer research.

[46]  R. Blomhoff,et al.  Isolation and cultivation of rat liver stellate cells. , 1990, Methods in enzymology.