Antitumor and Phytotoxic Activities of Leaf Methanol Extract of Oldenlandia diffusa (Willd.) Roxb

Oldenlandia diffusa (Willd.) Roxb., a well known medicinal plant in Bangladesh has been identified for antitumor properties through Agrobacterium tumefaciens infection using potato disc bioassay and phytotoxic effects on radish root and seed. Significant tumor inhibition was observed at 100ppm and 1000ppm of leaf methanol extract. Maximum tumor inhibition 40.98, 41.93 and 41.89% were observed at 1000ppm for the accessions of the Agrobacterium tumefaciens AtTa0112, AtAc0114 and AtSl0105, respectively. Phytotoxicity assay shows significant root length inhibition by the extract at the concentrations of 1000ppm and 10000ppm. Similarly, seed germinations were also significantly inhibited at the concentrations 1000ppm and 7500ppm extracts. Overall results supported that Oldenlandia diffusa might be a potential source of antitumor agent that could be used for further drug development for tumor treatment in human.

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