Effects of reduction in the alpha‐gal antigen on bony union: a model of xenobone graft using GalT knockout mouse

Among the bone graft sources used currently, the availability of autografts is limited and allografts are expensive. Therefore, xenobone grafts have drawn attention as a new source of bone grafts, although immunologic rejection issues are unresolved. This study used a GalT knockout mouse model to investigate the effects of reducing the alpha‐gal epitope using alpha‐galactosidase on the union of porcine xenobone grafts.

[1]  S. Choi,et al.  Removal of Alpha-Gal Epitopes from Porcine Aortic Valve and Pericardium using Recombinant Human Alpha Galactosidase A , 2009, Journal of Korean medical science.

[2]  U. Galili,et al.  Anterior cruciate ligament reconstruction with a porcine xenograft: a serologic, histologic, and biomechanical study in primates. , 2007, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[3]  U. Galili,et al.  Replacement of Human Anterior Cruciate Ligaments with Pig Ligaments: A Model for Anti-Non-Gal Antibody Response in Long-Term Xenotransplantation , 2007, Transplantation.

[4]  W. Feng,et al.  Distribution of the alpha-gal epitope on adult porcine bone tissue. , 2006, Transplantation proceedings.

[5]  U. Galili.  The α‐gal epitope and the anti‐Gal antibody in xenotransplantation and in cancer immunotherapy , 2005 .

[6]  P. Lehmann,et al.  Immunologic testing of xeno-derived osteochondral grafts using peripheral blood mononuclear cells from healthy human donors , 2005, BMC musculoskeletal disorders.

[7]  U. Galili.  The alpha-gal epitope and the anti-Gal antibody in xenotransplantation and in cancer immunotherapy. , 2005, Immunology and cell biology.

[8]  Su-Hyang Kim,et al.  Chemical, structural properties, and osteoconductive effectiveness of bone block derived from porcine cancellous bone. , 2004, Journal of biomedical materials research. Part B, Applied biomaterials.

[9]  Shan-ying Peng,et al.  [The alpha-gal epitope (Gal alpha 1-3 Gal beta 1-4 GlcNAc-R) in xenotransplantation]. , 2003, Sheng li ke xue jin zhan [Progress in physiology].

[10]  U. Galili,et al.  The α-Gal epitope (Galα1-3Galβ1-4GlcNAc-R) in xenotransplantation. , 2001, Biochimie.

[11]  U. Galili.  Evolution of alpha 1,3galactosyltransferase and of the alpha-Gal epitope. , 1999, Sub-cellular biochemistry.

[12]  U. Galili,et al.  Porcine and bovine cartilage transplants in cynomolgus monkey: II. Changes in anti-Gal response during chronic rejection. , 1997, Transplantation.

[13]  K. Heiple,et al.  Bone grafting: Role of histocompatibility in transplantation , 1985, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.