Resorbable biomaterials as bone graft substitutes

An ageing population and the democratization of high-risk sports have led to a surge of bone-related diseases and bone fractures. As a result, the use of bone graft substitutes has dramatically increased in the last decade. A wide range of materials are considered, from metals to polymers, from injectable cements to complex porous solids. This article aims at presenting a concise, accessible overview of the field of resorbable bone graft substitute materials. A slight emphasis is set on synthetic materials, in particular calcium phosphates.

[1]  G. Muschler,et al.  Bone graft materials. An overview of the basic science. , 2000, Clinical orthopaedics and related research.

[2]  J. Lemaître,et al.  Biomechanical characterization of a biodegradable calcium phosphate hydraulic cement: a comparison with porous biphasic calcium phosphate ceramics. , 1998, Journal of biomedical materials research.

[3]  S. Teitelbaum,et al.  Bone resorption by osteoclasts. , 2000, Science.

[4]  J. Lu,et al.  Role of interconnections in porous bioceramics on bone recolonization in vitro and in vivo , 1999, Journal of materials science. Materials in medicine.

[5]  J. Suh,et al.  Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review. , 2000, Biomaterials.

[6]  Gamal Baroud,et al.  A physical approach to modify the hydraulic reactivity of alpha-tricalcium phosphate powder. , 2009, Acta biomaterialia.

[7]  A. Nissan,et al.  Crosslinked chitosan implants as potential degradable devices for brachytherapy: in vitro and in vivo analysis. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[8]  Ajay Kumar Gupta,et al.  Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. , 2005, Biomaterials.

[9]  L. Grover,et al.  Mechanical activation and cement formation of β-tricalcium phosphate , 2003 .

[10]  J. Vacanti,et al.  Tissue engineering : Frontiers in biotechnology , 1993 .

[11]  Faleh Tamimi,et al.  Bone regeneration in rabbit calvaria with novel monetite granules. , 2008, Journal of biomedical materials research. Part A.

[12]  Larry L. Hench,et al.  Bonding mechanisms at the interface of ceramic prosthetic materials , 1971 .

[13]  H. Deramond,et al.  [Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty]. , 1987, Neuro-Chirurgie.

[14]  Eduardo Saiz,et al.  Freezing as a Path to Build Complex Composites , 2006, Science.

[15]  S. Perren,et al.  Tissue response and in vivo degradation of selected polyhydroxyacids: polylactides (PLA), poly(3-hydroxybutyrate) (PHB), and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHB/VA). , 1993, Journal of biomedical materials research.

[16]  S. Hirano,et al.  N-acetylation in chitosan and the rate of its enzymic hydrolysis. , 1989, Biomaterials.

[17]  O. Suzuki,et al.  Subperiosteal lmplantation of octacalcium phosphate (OCP) stimulates both chondrogenesis and osteogenesis in the tibia, but only osteogenesis in the parietal bone of a rat , 1995, The Anatomical record.

[18]  Ludwig J. Gauckler,et al.  Bioinspired Design and Assembly of Platelet Reinforced Polymer Films , 2008, Science.

[19]  D. Kaplan,et al.  Porosity of 3D biomaterial scaffolds and osteogenesis. , 2005, Biomaterials.

[20]  G. Baroud,et al.  Injectability of calcium phosphate pastes. , 2005, Biomaterials.

[21]  S. Takagi,et al.  Formation of macropores in calcium phosphate cement implants , 2001, Journal of materials science. Materials in medicine.

[22]  E. Munting,et al.  Bone repair of defects filled with a phosphocalcic hydraulic cement: an in vivo study , 1993 .

[23]  C. V. van Blitterswijk,et al.  Bone tissue engineering in a critical size defect compared to ectopic implantations in the goat , 2004, Journal of Orthopaedic Research.

[24]  P. Uggowitzer,et al.  MgZnCa glasses without clinically observable hydrogen evolution for biodegradable implants. , 2009, Nature materials.

[25]  S. Hollister.  Porous scaffold design for tissue engineering , 2005, Nature materials.

[26]  G. Hofmann,et al.  Infections and immunological hazards of allogeneic bone transplantation , 2004, Archives of Orthopaedic and Trauma Surgery.

[27]  P. Krebsbach,et al.  Isolation and Characterization of MC3T3‐E1 Preosteoblast Subclones with Distinct In Vitro and In Vivo Differentiation/Mineralization Potential , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[28]  J. Hubbell,et al.  Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering , 2005, Nature Biotechnology.

[29]  R. Ritchie,et al.  Tough, Bio-Inspired Hybrid Materials , 2008, Science.

[30]  D. Roy,et al.  Hydroxyapatite formed from Coral Skeletal Carbonate by Hydrothermal Exchange , 1974, Nature.

[31]  B. Bai,et al.  The use of an injectable, biodegradable calcium phosphate bone substitute for the prophylactic augmentation of osteoporotic vertebrae and the management of vertebral compression fractures. , 1999, Spine.

[32]  M. Alini,et al.  Degradable polymeric materials for osteosynthesis: tutorial. , 2008, European cells & materials.

[33]  Jeffrey A. Hubbell,et al.  Polymeric biomaterials with degradation sites for proteases involved in cell migration , 1999 .

[34]  Philipp Beerbaum,et al.  Long-term biocompatibility of a corrodible peripheral iron stent in the porcine descending aorta. , 2006, Biomaterials.

[35]  M. Bohner,et al.  Resorption of, and bone formation from, new beta-tricalcium phosphate-monocalcium phosphate cements: an in vivo study. , 1996, Journal of biomedical materials research.

[36]  Fraser Buchanan,et al.  Degradation rate of bioresorbable materials , 2008 .

[37]  Katsumi Yoshida,et al.  Substitution Model of Monovalent (Li, Na, and K), Divalent (Mg), and Trivalent (Al) Metal Ions for β‐Tricalcium Phosphate , 2006 .

[38]  X. Zhu,et al.  Polymer microspheres for controlled drug release. , 2004, International journal of pharmaceutics.

[39]  F. H. Albee.  STUDIES IN BONE GROWTH: TRIPLE CALCIUM PHOSPHATE AS A STIMULUS TO OSTEOGENESIS. , 1920, Annals of surgery.

[40]  B. Oesch,et al.  Analysis of the risk of transmitting bovine spongiform encephalopathy through bone grafts derived from bovine bone. , 2001, Biomaterials.

[41]  C. Adams,et al.  Inorganic phosphate induces apoptosis of osteoblast-like cells in culture. , 2000, Bone.

[42]  Clemens A van Blitterswijk,et al.  Osteoconduction and osteoinduction of low-temperature 3D printed bioceramic implants. , 2008, Biomaterials.

[43]  M Bohner,et al.  Theoretical model to determine the effects of geometrical factors on the resorption of calcium phosphate bone substitutes. , 2004, Biomaterials.

[44]  S. Goodman,et al.  Histological, chemical, and crystallographic analysis of four calcium phosphate cements in different rabbit osseous sites. , 1998, Journal of biomedical materials research.

[45]  J. Brilliant,et al.  Tricalcium phosphate as an adjunct to apical closure in pulpless permanent teeth. , 1975, Journal of endodontics.

[46]  Norio Itoh,et al.  Requirement of calcium and phosphate ions in expression of sodium-dependent vitamin C transporter 2 and osteopontin in MC3T3-E1 osteoblastic cells. , 2003, Biochimica et biophysica acta.

[47]  G. W. Hastings,et al.  Book reviewDefinitions in Biomaterials: Progress in Biomedical Engineering 4, Editor: D.F. Williams. Elsevier, Amsterdam, 1987, pp viii + 72, US $63.50 , 1989 .

[48]  M. Chapman,et al.  Morbidity at bone graft donor sites. , 1989, Journal of orthopaedic trauma.

[49]  H. Chambers,et al.  Complications of iliac crest bone graft harvesting. , 1996, Clinical orthopaedics and related research.

[50]  J. Wiltfang,et al.  Intraindividual Comparative Animal Study of &agr;- and &bgr;-Tricalcium Phosphate Degradation in Conjunction with Simultaneous Insertion of Dental Implants , 2001, The Journal of craniofacial surgery.

[51]  Frank Witte,et al.  In vitro and in vivo corrosion measurements of magnesium alloys. , 2006, Biomaterials.

[52]  Cato T. Laurencin,et al.  Bone-Graft Substitutes: Facts, Fictions, and Applications , 2001, The Journal of bone and joint surgery. American volume.

[53]  M. Sayer,et al.  Silicon substitution in the calcium phosphate bioceramics. , 2007, Biomaterials.

[54]  Michel Vert,et al.  Polymeric biomaterials: Strategies of the past vs. strategies of the future , 2007 .

[55]  D. Hutmacher,et al.  Scaffolds in tissue engineering bone and cartilage. , 2000, Biomaterials.

[56]  M. Fukase,et al.  Effect of elevated extracellular calcium on the proliferation of osteoblastic MC3T3-E1 cells:its direct and indirect effects via monocytes. , 1991, Biochemical and biophysical research communications.

[57]  Jack E. Lemons,et al.  Quantitative characterization and performance of porous implants for hard tissue applications : a symposium sponsored by ASTM Committee F-4 on Medical and Surgical Materials and Devices, Nashville, TN, 18-19 Nov. 1985 , 1987 .

[58]  James M. Anderson,et al.  The future of biomedical materials , 2006, Journal of materials science. Materials in medicine.

[59]  G. Baroud,et al.  Theoretical and experimental approach to test the cohesion of calcium phosphate pastes. , 2006, European cells & materials.

[60]  H. Datta,et al.  'Calcium-activated' intracellular calcium elevation: a novel mechanism of osteoclast regulation. , 1989, Biochemical and biophysical research communications.

[61]  H. Seeherman,et al.  rhBMP-2/calcium phosphate matrix accelerates osteotomy-site healing in a nonhuman primate model at multiple treatment times and concentrations. , 2006, The Journal of bone and joint surgery. American volume.

[62]  A. Engström‐Làurent,et al.  ELIMINATION OF HYALURONIC ACID FROM THE BLOOD STREAM IN THE HUMAN , 1984, Clinical and experimental pharmacology & physiology.

[63]  A. Bigi,et al.  Nanocrystals of magnesium and fluoride substituted hydroxyapatite. , 1998, Journal of inorganic biochemistry.

[64]  C. Wilkinson,et al.  The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder. , 2007, Nature materials.

[65]  Pamela Habibovic,et al.  Osteoinductive biomaterials—properties and relevance in bone repair , 2007, Journal of tissue engineering and regenerative medicine.

[66]  M. Bohner,et al.  Silicon-substituted calcium phosphates - a critical view. , 2009, Biomaterials.

[67]  G. Daculsi,et al.  Osteoclastic resorption of calcium phosphate ceramics with different hydroxyapatite/beta-tricalcium phosphate ratios. , 1997, Biomaterials.

[68]  Banwart Jc,et al.  Iliac crest bone graft harvest donor site morbidity. A statistical evaluation. , 1995 .

[69]  J. Klawitter,et al.  Application of porous ceramics for the attachment of load bearing internal orthopedic applications , 1971 .

[70]  O. Suzuki,et al.  Bone regeneration by synthetic octacalcium phosphate and its role in biological mineralization. , 2008, Current medicinal chemistry.

[71]  Gladius Lewis,et al.  Injectable bone cements for use in vertebroplasty and kyphoplasty: state-of-the-art review. , 2006, Journal of biomedical materials research. Part B, Applied biomaterials.

[72]  O. Nakade,et al.  Effect of extracellular calcium on the gene expression of bone morphogenetic protein-2 and -4 of normal human bone cells , 2001, Journal of Bone and Mineral Metabolism.