The variance shared across forms of childhood trauma is strongly associated with liability for psychiatric and substance use disorders

Forms of childhood trauma tend to co‐occur and are associated with increased risk for psychiatric and substance use disorders. Commonly used binary measures of trauma exposure have substantial limitations.

[1]  R. Mattick,et al.  Child maltreatment as a risk factor for opioid dependence: Comparison of family characteristics and type and severity of child maltreatment with a matched control group. , 2009, Child abuse & neglect.

[2]  D M Fergusson,et al.  Physical punishment/maltreatment during childhood and adjustment in young adulthood. , 1997, Child abuse & neglect.

[3]  J. Nurnberger,et al.  A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. , 1994, Journal of studies on alcohol.

[4]  D. Fergusson,et al.  Childhood sexual abuse and psychiatric disorder in young adulthood: I. Prevalence of sexual abuse and factors associated with sexual abuse. , 1996, Journal of the American Academy of Child and Adolescent Psychiatry.

[5]  Philip Spinhoven,et al.  Childhood Trauma Questionnaire: factor structure, measurement invariance, and validity across emotional disorders. , 2014, Psychological assessment.

[6]  Beth E. Molnar,et al.  Child sexual abuse and subsequent psychopathology: results from the National Comorbidity Survey. , 2001, American journal of public health.

[7]  N. Martin,et al.  Clustering of Trauma and Associations with Single and Co-Occurring Depression and Panic Attack over Twenty Years , 2010, Twin Research and Human Genetics.

[8]  N. Martin,et al.  Cannabinoid receptor genotype moderation of the effects of childhood physical abuse on anhedonia and depression. , 2012, Archives of general psychiatry.

[9]  L. Bierut,et al.  Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men , 1997, Psychological Medicine.

[10]  R. Poulin.  SPECIES RICHNESS OF PARASITE ASSEMBLAGES: Evolution and Patterns , 1997 .

[11]  M. Schwandt,et al.  Impact of multiple types of childhood trauma exposure on risk of psychiatric comorbidity among alcoholic inpatients. , 2012, Alcoholism, clinical and experimental research.

[12]  N. Wray,et al.  ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure. , 2013, JAMA psychiatry.

[13]  L J Horwood,et al.  Childhood sexual abuse and psychiatric disorder in young adulthood: II. Psychiatric outcomes of childhood sexual abuse. , 1996, Journal of the American Academy of Child and Adolescent Psychiatry.

[14]  K. Kendler,et al.  Childhood sexual abuse and adult psychiatric and substance use disorders in women: an epidemiological and cotwin control analysis. , 2000, Archives of general psychiatry.

[15]  R. Kessler,et al.  Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication II: associations with persistence of DSM-IV disorders. , 2010, Archives of general psychiatry.

[16]  M. Straus,et al.  The Neglect Scale. , 1997 .

[17]  M. Newcomb,et al.  Development and validation of a brief screening version of the Childhood Trauma Questionnaire. , 2003, Child abuse & neglect.

[18]  N. Martin,et al.  Spousal concordance for alcohol dependence: evidence for assortative mating or spousal interaction effects? , 2007, Alcoholism, clinical and experimental research.

[19]  U. John,et al.  Moderation of adult depression by the serotonin transporter promoter variant (5‐HTTLPR), childhood abuse and adult traumatic events in a general population sample , 2012, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[20]  L. Degenhardt,et al.  Sex differences amongst dependent heroin users: histories, clinical characteristics and predictors of other substance dependence. , 2011, Addictive behaviors.

[21]  N. Martin,et al.  Predictors of Non-Response to a Questionnaire Survey of a Volunteer Twin Panel: Findings from the Australian 1989 Twin Cohort , 2001, Twin Research.

[22]  A. Roy,et al.  Interaction between FKBP5 and childhood trauma and risk of aggressive behavior. , 2012, Archives of general psychiatry.

[23]  Jochen Hardt,et al.  Validity of adult retrospective reports of adverse childhood experiences: review of the evidence. , 2004, Journal of child psychology and psychiatry, and allied disciplines.

[24]  Christopher G. Davis,et al.  Childhood adversity and adult psychiatric disorder in the US National Comorbidity Survey , 1997, Psychological Medicine.

[25]  D. Rosielle,et al.  Psychiatry , 1905, NeuroImage.

[26]  N. Martin,et al.  Association between self-reported childhood sexual abuse and adverse psychosocial outcomes: results from a twin study. , 2002, Archives of general psychiatry.

[27]  M. Stein,et al.  The Childhood Trauma Questionnaire in a Community Sample: Psychometric Properties and Normative Data , 2001, Journal of traumatic stress.

[28]  Sarah E. Medland,et al.  A Quantitative-Trait Genome-Wide Association Study of Alcoholism Risk in the Community: Findings and Implications , 2011, Biological Psychiatry.

[29]  L. Crocker,et al.  Introduction to Classical and Modern Test Theory , 1986 .

[30]  N. Martin,et al.  A Family Study of Adult Twins with and without a History of Childhood Abuse: Stability of Retrospective Reports of Maltreatment and Associated Family Measures , 2010, Twin Research and Human Genetics.

[31]  B. Muthén,et al.  Applying Multigroup Confirmatory Factor Models for Continuous Outcomes to Likert Scale Data Complicates Meaningful Group Comparisons , 2004 .

[32]  R. Kessler,et al.  Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication I: associations with first onset of DSM-IV disorders. , 2010, Archives of general psychiatry.

[33]  Anthony S. Bryk,et al.  Hierarchical Linear Models: Applications and Data Analysis Methods , 1992 .

[34]  Katherine M Keyes,et al.  Childhood maltreatment and the structure of common psychiatric disorders , 2012, British Journal of Psychiatry.

[35]  D. Williamson,et al.  The interrelatedness of multiple forms of childhood abuse, neglect, and household dysfunction. , 2004, Child abuse & neglect.

[36]  N. Martin,et al.  Common heritable contributions to low-risk trauma, high-risk trauma, posttraumatic stress disorder, and major depression. , 2012, Archives of general psychiatry.

[37]  N. Martin,et al.  Childhood sexual abuse and risks for licit and illicit drug-related outcomes: a twin study , 2006, Psychological Medicine.

[38]  P. Ellis,et al.  Prospectively ascertained child maltreatment and its association with DSM-IV mental disorders in young adults. , 2010, Archives of general psychiatry.

[39]  L J Horwood,et al.  The Christchurch Child Development Study: a review of epidemiological findings. , 1989, Paediatric and perinatal epidemiology.

[40]  G. Herbison,et al.  Childhood Sexual Abuse and Mental Health in Adult Life , 1993, British Journal of Psychiatry.

[41]  Murray A. Straus,et al.  Measuring intrafamily conflict and violence: The Conflict Tactics (CT) Scales. , 1979 .

[42]  Alexander Teumer,et al.  Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse , 2012, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[43]  W. Meredith.  Measurement invariance, factor analysis and factorial invariance , 1993 .

[44]  N. Martin,et al.  Maternal alcohol use disorder and offspring ADHD: disentangling genetic and environmental effects using a children-of-twins design , 2006, Psychological Medicine.

[45]  B. Muthén.  A general structural equation model with dichotomous, ordered categorical, and continuous latent variable indicators , 1984 .