Improved oral bioavailability of cyclosporin A in male Wistar rats. Comparison of a Solutol HS 15 containing self-dispersing formulation and a microsuspension.

[1]  J. Elashoff,et al.  Postcibal Gastric Emptying of Pancreatin Pellets: Effects of Dose and Meal Oil , 2001, Digestive Diseases and Sciences.

[2]  Beate Bittner,et al.  Intravenous administration of poorly soluble new drug entities in early drug discovery: the potential impact of formulation on pharmacokinetic parameters. , 2002, Current opinion in drug discovery & development.

[3]  S. Benita,et al.  Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs. , 2000, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[4]  M. Maurin,et al.  Improved oral bioavailability of the hypocholesterolemic DMP 565 in dogs following oral dosing in oil and glycol solutions. , 1997, Biopharmaceutics & drug disposition.

[5]  Morton B. Brown,et al.  Role of intestinal P‐glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine , 1997, Clinical pharmacology and therapeutics.

[6]  G. Koren Bias against the null hypothesis in maternal‐fetal pharmacology and toxicology , 1997, Clinical pharmacology and therapeutics.

[7]  C. Beglinger,et al.  Relevance of p‐glycoprotein for the enteral absorption of cyclosporin A: in vitro‐in vivo correlation , 1996, British journal of pharmacology.

[8]  S. Friman,et al.  A New Microemulsion Formulation of Cyclosporin , 1996, Clinical pharmacokinetics.

[9]  L. Benet,et al.  The effect of water‐soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers , 1996, Clinical pharmacology and therapeutics.

[10]  J. Coon,et al.  Reversal of multi‐drug resistance in vitro by fatty acid PEG fatty acid diesters , 1996, International journal of cancer.

[11]  D. Niese,et al.  Safety and tolerability of a new oral formulation of cyclosporin A, Sandimmun Neoral, in renal transplant patients , 1994, Transplant international : official journal of the European Society for Organ Transplantation.

[12]  J. Kovarik,et al.  Blood cyclosporin A and metabolite kinetic profiles after administration of Sandimmune soft gelatine capsules and Neoral in transplant recipients. , 1994, Transplantation proceedings.

[13]  D. Grant,et al.  Potential for CsA-Neoral in organ transplantation. , 1994, Transplantation proceedings.

[14]  J. Kovarik,et al.  Reduced inter- and intraindividual variability in cyclosporine pharmacokinetics from a microemulsion formulation. , 1994, Journal of pharmaceutical sciences.

[15]  M O Karlsson,et al.  Dose dependent absorption and linear disposition of cyclosporin A in rat , 1994, Biopharmaceutics & drug disposition.

[16]  A. Fahr Cyclosporin Clinical Pharmacokinetics , 1993, Clinical pharmacokinetics.

[17]  Y. Tanigawara,et al.  Human P-glycoprotein transports cyclosporin A and FK506. , 1993, The Journal of biological chemistry.

[18]  C. Beglinger,et al.  The absorption site of cyclosporin in the human gastrointestinal tract. , 1992, British journal of clinical pharmacology.

[19]  J. Dressman,et al.  Unusual solubility behaviour of cyclosporin A in aqueous media , 1991, The Journal of pharmacy and pharmacology.

[20]  D. Back,et al.  Cyclosporin metabolism by the gastrointestinal mucosa. , 1991, British journal of clinical pharmacology.

[21]  W. Ritschel,et al.  Improvement of peroral absorption of cyclosporine A by microemulsions. , 1990, Methods and findings in experimental and clinical pharmacology.

[22]  D. V. van Thiel,et al.  Effect of bile on cyclosporin absorption in liver transplant patients. , 1988, British journal of clinical pharmacology.

[23]  R. Venkataramanan,et al.  Clinical Pharmacokinetics of Cyclosporin , 1986, Clinical pharmacokinetics.

[24]  D. Holt,et al.  The effect of vehicle on the oral absorption of cyclosporin. , 1986, British journal of clinical pharmacology.

[25]  B D Kahan,et al.  INDIVIDUALIZATION OF CYCLOSPORINE THERAPY USING PHARMACOKINETIC AND PHARMACODYNAMIC PARAMETERS , 1985, Transplantation.

[26]  N. Shibata,et al.  Promotion of the selective lymphatic delivery of cyclosporin A by lipid-surfactant mixed micelles. , 1985, Journal of pharmacobio-dynamics.

[27]  M. Lemaire,et al.  Apparent dose-dependent oral absorption of cyclosporin A in rats. , 1984, Biopharmaceutics & drug disposition.

[28]  M. Lemaire,et al.  Intestinal lymphatic absorption of cyclosporin A following oral administration in an olive oil solution in rats. , 1983, Biopharmaceutics & drug disposition.

[29]  C. T. Ueda,et al.  Preliminary observations on the absorption of liposome-encapsulated drug by the intestinal lymphatics. , 1981, Research communications in chemical pathology and pharmacology.