Carbonic anhydrases

[1]  C. Supuran.  Carbonic anhydrase inhibitors as emerging agents for the treatment and imaging of hypoxic tumors , 2018, Expert opinion on investigational drugs.

[2]  C. Supuran,et al.  The carbonic anhydrase IX inhibitor SLC-0111 sensitises cancer cells to conventional chemotherapy , 2018, Journal of enzyme inhibition and medicinal chemistry.

[3]  A. Sudo,et al.  Carbonic anhydrase IX enhances tumor cell proliferation and tumor progression in osteosarcoma , 2018, OncoTargets and therapy.

[4]  J. Deitmer,et al.  A surface proton antenna in carbonic anhydrase II supports lactate transport in cancer cells , 2018, eLife.

[5]  D. Felder-Flesch,et al.  Umbelliferone Decreases Intracellular pH and Sensitizes Melanoma Cell Line A375 to Dacarbazin. Comparison with Acetazolamide. , 2018, Current molecular pharmacology.

[6]  C. Supuran,et al.  Selective inhibition of carbonic anhydrase-IX by sulphonamide derivatives induces pH and reactive oxygen species-mediated apoptosis in cervical cancer HeLa cells , 2018, Journal of enzyme inhibition and medicinal chemistry.

[7]  Emily R. Gordon,et al.  Addition of carbonic anhydrase 9 inhibitor SLC-0111 to temozolomide treatment delays glioblastoma growth in vivo. , 2017, JCI insight.

[8]  A. Crisci,et al.  Plasmatic carbonic anhydrase IX as a diagnostic marker for clear cell renal cell carcinoma , 2017, Journal of enzyme inhibition and medicinal chemistry.

[9]  A. Linē,et al.  Depletion of carbonic anhydrase IX abrogates hypoxia-induced overexpression of stanniocalcin-1 in triple negative breast cancer cells , 2017, Cancer biology & therapy.

[10]  S. Miyamoto,et al.  Impact of Acetazolamide, a Carbonic Anhydrase Inhibitor, on the Development of Intestinal Polyps in Min Mice , 2017, International journal of molecular sciences.

[11]  S. Baruchel,et al.  Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma , 2017, BMC Cancer.

[12]  J. Pouysségur,et al.  Genetic disruption of the pHi-regulating proteins Na+/H+ exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells , 2016, Oncotarget.

[13]  M. Sonobe,et al.  Hypoxia‐inducible factor 1 promotes chemoresistance of lung cancer by inducing carbonic anhydrase IX expression , 2016, Cancer medicine.

[14]  R. Bartha,et al.  Topiramate induces acute intracellular acidification in glioblastoma , 2016, Journal of Neuro-Oncology.

[15]  N. Demartines,et al.  Targeting carbonic anhydrase IX improves the anti-cancer efficacy of mTOR inhibitors , 2016, Oncotarget.

[16]  J. Hatina,et al.  Simultaneous Targeting of Bladder Tumor Growth, Survival, and Epithelial-to-Mesenchymal Transition with a Novel Therapeutic Combination of Acetazolamide (AZ) and Sulforaphane (SFN) , 2016, Targeted Oncology.

[17]  F. Sbrana,et al.  Carbonic anhydrase IX inhibition is an effective strategy for osteosarcoma treatment , 2015, Expert opinion on therapeutic targets.

[18]  Shun-Fa Yang,et al.  Carbonic anhydrase IX overexpression regulates the migration and progression in oral squamous cell carcinoma , 2015, Tumor Biology.

[19]  A. Stopeck,et al.  Assessment of carbonic anhydrase IX expression and extracellular pH in B-cell lymphoma cell line models , 2015, Leukemia & lymphoma.

[20]  J. Kopecka,et al.  Carbonic anhydrase XII is a new therapeutic target to overcome chemoresistance in cancer cells , 2015, Oncotarget.

[21]  K. Silina,et al.  Prognostic relevance of carbonic anhydrase IX expression is distinct in various subtypes of breast cancer and its silencing suppresses self-renewal capacity of breast cancer cells , 2015, Cancer Chemotherapy and Pharmacology.

[22]  S. C. Chafe,et al.  Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche , 2013, Oncogene.

[23]  H. Yeger,et al.  Combination of carbonic anhydrase inhibitor, acetazolamide, and sulforaphane, reduces the viability and growth of bronchial carcinoid cell lines , 2013, BMC Cancer.

[24]  J. Healey,et al.  Additive Influence of Extracellular pH, Oxygen Tension, and Pressure on Invasiveness and Survival of Human Osteosarcoma Cells , 2013, Front. Oncol..

[25]  C. Supuran,et al.  Hypoxia induced CA9 inhibitory targeting by two different sulfonamide derivatives including acetazolamide in human glioblastoma. , 2013, Bioorganic & medicinal chemistry.

[26]  Thijs J. Hagenbeek,et al.  Pharmacological inhibition of carbonic anhydrase XII interferes with cell proliferation and induces cell apoptosis in T-cell lymphomas. , 2013, Cancer letters.

[27]  E. Giannoni,et al.  Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells , 2013, Cell cycle.

[28]  Marcus Schmidt,et al.  Relevance of cellular and serum carbonic anhydrase IX in primary breast cancer , 2013, Journal of Cancer Research and Clinical Oncology.

[29]  A. Scaloni,et al.  Characterization of carbonic anhydrase IX interactome reveals proteins assisting its nuclear localization in hypoxic cells. , 2013, Journal of proteome research.

[30]  M. Proescholdt,et al.  Function of carbonic anhydrase IX in glioblastoma multiforme. , 2012, Neuro-oncology.

[31]  W. Sly,et al.  Carbonic anhydrase isozymes II, IX, and XII in uterine tumors , 2012, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[32]  Kong Bin,et al.  Acetazolamide inhibits aquaporin-1 expression and colon cancer xenograft tumor growth. , 2011, Hepato-gastroenterology.

[33]  P. Fasching,et al.  Prospective evaluation of serum tissue inhibitor of metalloproteinase 1 and carbonic anhydrase IX in correlation to circulating tumor cells in patients with metastatic breast cancer , 2011, Breast Cancer Research.

[34]  Y. Li,et al.  Catalysis and pH Control by Membrane-associated Carbonic Anhydrase IX in MDA-MB-231 Breast Cancer Cells* , 2011, The Journal of Biological Chemistry.

[35]  P. Argani,et al.  Carbonic anhydrase IX expression in renal neoplasms: correlation with tumor type and grade. , 2010, American journal of clinical pathology.

[36]  C. Supuran,et al.  Selective Inhibition of Carbonic Anhydrase IX Decreases Cell Proliferation and Induces Ceramide-Mediated Apoptosis in Human Cancer Cells , 2010, Journal of Pharmacology and Experimental Therapeutics.

[37]  R. Simon,et al.  Overexpression of carbonic anhydrase IX (CAIX) in vulvar cancer is associated with tumor progression and development of locoregional lymph node metastases , 2010, Virchows Archiv.

[38]  B. Monk,et al.  Prognostic relevance of carbonic anhydrase-IX in high-risk, early-stage cervical cancer: a Gynecologic Oncology Group study. , 2010, Gynecologic oncology.

[39]  A. Scaloni,et al.  Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX , 2009, Proceedings of the National Academy of Sciences.

[40]  Dario Neri,et al.  In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives. , 2009, Bioorganic & medicinal chemistry letters.

[41]  M. Lerman,et al.  Transcriptional control of the tumor- and hypoxia-marker carbonic anhydrase 9: A one transcription factor (HIF-1) show? , 2009, Biochimica et biophysica acta.

[42]  A. Belldegrun,et al.  Carbonic anhydrase IX in bladder cancer , 2009, Cancer.

[43]  A. Scaloni,et al.  Biochemical Characterization of CA IX, One of the Most Active Carbonic Anhydrase Isozymes* , 2008, Journal of Biological Chemistry.

[44]  A. Harris,et al.  Tumor-associated Carbonic Anhydrase 9 Spatially Coordinates Intracellular pH in Three-dimensional Multicellular Growths* , 2008, Journal of Biological Chemistry.

[45]  B. Katzenellenbogen,et al.  Estrogen receptor regulation of carbonic anhydrase XII through a distal enhancer in breast cancer. , 2008, Cancer research.

[46]  Claudiu T. Supuran,et al.  Carbonic anhydrases: novel therapeutic applications for inhibitors and activators , 2008, Nature Reviews Drug Discovery.

[47]  Richard D. Vaughan-Jones,et al.  Regulation of tumor pH and the role of carbonic anhydrase 9 , 2007, Cancer and Metastasis Reviews.

[48]  Xue-jun Li,et al.  Effects of Acetazolamide Combined with or without NaHCO3 on Suppressing Neoplasm Growth, Metastasis and Aquaporin-1 (AQP1) Protein Expression , 2007, International Journal of Molecular Sciences.

[49]  D. Rea,et al.  Hypoxia-regulated carbonic anhydrase IX expression is associated with poor survival in patients with invasive breast cancer , 2007, British Journal of Cancer.

[50]  C. Ling,et al.  Detecting changes in tumor hypoxia with carbonic anhydrase IX and pimonidazole , 2007, Cancer biology & therapy.

[51]  A. Ochiai,et al.  Carbonic anhydrase IX expression is associated with tumor progression and a poor prognosis of lung adenocarcinoma. , 2006, Lung cancer.

[52]  W. Sly,et al.  Expression of transmembrane carbonic anhydrases IX and XII in ovarian tumours , 2006, Histopathology.

[53]  S. Fox,et al.  Role of carbonic anhydrase IX expression in prediction of the efficacy and outcome of primary epirubicin/tamoxifen therapy for breast cancer. , 2006, Endocrine-related cancer.

[54]  M. Flentje,et al.  Distinct patterns of hypoxic expression of carbonic anhydrase IX (CA IX) in human malignant glioma cell lines , 2006, Journal of Neuro-Oncology.

[55]  P. Malfertheiner,et al.  Expression of carbonic anhydrase 9 at the invasion front of gastric cancers , 2005, Gut.

[56]  S. Signoretti,et al.  Carbonic Anhydrase IX Expression Predicts Outcome of Interleukin 2 Therapy for Renal Cancer , 2005, Clinical Cancer Research.

[57]  S. Parkkila,et al.  Expression of a novel carbonic anhydrase, CA XIII, in normal and neoplastic colorectal mucosa , 2005, BMC Cancer.

[58]  C. Supuran,et al.  Hypoxia activates the capacity of tumor‐associated carbonic anhydrase IX to acidify extracellular pH , 2004, FEBS letters.

[59]  M. Lerman,et al.  DNA Damage Is a Prerequisite for p53-Mediated Proteasomal Degradation of HIF-1α in Hypoxic Cells and Downregulation of the Hypoxia Marker Carbonic Anhydrase IX , 2004, Molecular and Cellular Biology.

[60]  Xue-jun Li,et al.  Acetazolamide inhibits aquaporin-1 protein expression and angiogenesis. , 2004, Acta Pharmacologica Sinica.

[61]  A. Harris,et al.  Hypoxia Inducible Carbonic Anhydrase IX, Marker of Tumour: Hypoxia, Survival Pathway and Therapy Target , 2004, Cell cycle.

[62]  G. Klebe,et al.  Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition. , 2004, Journal of medicinal chemistry.

[63]  J. Pastorek,et al.  Carbonic anhydrase IX reduces E-cadherin-mediated adhesion of MDCK cells via interaction with β-catenin , 2003 .

[64]  C. Sweep,et al.  Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: association with treatment outcome , 2003, British Journal of Cancer.

[65]  Claudiu T Supuran,et al.  Carbonic anhydrase inhibitors. , 2003, Bioorganic & medicinal chemistry letters.

[66]  E. Stanbridge,et al.  Expression of the hypoxia marker carbonic anhydrase IX is critically dependent on SP1 activity. Identification of a novel type of hypoxia-responsive enhancer. , 2003, Cancer research.

[67]  Steve Horvath,et al.  Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[68]  Xue-jun Li,et al.  Acetazolamide suppresses tumor metastasis and related protein expression in mice bearing Lewis lung carcinoma. , 2002, Acta pharmacologica Sinica.

[69]  A. Harris,et al.  Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

[70]  W. Sly,et al.  The expression of carbonic anhydrase II in hematological malignancies. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

[71]  M. Lerman,et al.  Carbonic anhydrase 9 as an endogenous marker for hypoxic cells in cervical cancer. , 2001, Cancer research.

[72]  A. Harris,et al.  Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer. , 2001, Cancer research.

[73]  A. Harris,et al.  Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. , 2001, Cancer research.

[74]  A. Harris,et al.  Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[75]  A. Harris,et al.  Carbonic anhydrase IX, an endogenous hypoxia marker, expression in head and neck squamous cell carcinoma and its relationship to hypoxia, necrosis, and microvessel density. , 2001, Cancer research.

[76]  Andrea Scozzafava,et al.  Carbonic anhydrase inhibitors. , 2001, Medicinal research reviews.

[77]  Alun D. Hughes,et al.  In vivo evidence for KCa channel opening properties of acetazolamide in the human vasculature , 2001, British journal of pharmacology.

[78]  P H Watson,et al.  Hypoxia-inducible expression of tumor-associated carbonic anhydrases. , 2000, Cancer research.

[79]  W. Sly,et al.  Expression of transmembrane carbonic anhydrase isoenzymes IX and XII in normal human pancreas and pancreatic tumours , 2000, Histochemistry and Cell Biology.

[80]  W. Sly,et al.  Carbonic anhydrase inhibitor suppresses invasion of renal cancer cells in vitro. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[81]  C. Supuran,et al.  Carbonic Anhydrase Inhibitors: Aromatic Sulfonamides and Disulfonamides Act as Efficient Tumor Growth Inhibitors , 2000, Journal of enzyme inhibition.

[82]  R. Shank,et al.  An Overview of the Preclinical Aspects of Topiramate: Pharmacology, Pharmacokinetics, and Mechanism of Action , 2000, Epilepsia.

[83]  J. Pastorek,et al.  Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation. , 1998, The American journal of pathology.

[84]  G N Shah,et al.  Human carbonic anhydrase XII: cDNA cloning, expression, and chromosomal localization of a carbonic anhydrase gene that is overexpressed in some renal cell cancers. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[85]  R. Kettmann,et al.  Human MN/CA9 gene, a novel member of the carbonic anhydrase family: structure and exon to protein domain relationships. , 1996, Genomics.

[86]  J. Pastorek,et al.  Expression of MaTu‐MN protein in human tumor cultures and in clinical specimens , 1993, International journal of cancer.

[87]  S. Wysocki,et al.  Detection of mRNA for carbonic anhydrase II in human osteoclast‐like cells by in situ hybridization , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[88]  S. Pastoreková,et al.  A novel quasi-viral agent, MaTu, is a two-component system. , 1992, Virology.

[89]  W. Stadie,et al.  THE CATALYSIS OF THE HYDRATION OF CARBON DIOXIDE AND DEHYDRATION OF CARBONIC ACID BY AN ENZYME ISOLATED FROM RED BLOOD CELLS , 1933 .

[90]  C. Supuran,et al.  Novel carbonic anhydrase IX‐targeted therapy enhances the anti‐tumour effects of cisplatin in small cell lung cancer , 2018, International journal of cancer.

[91]  O. Thews,et al.  Inhibition of Carbonic Anhydrase IX by Ureidosulfonamide Inhibitor U104 Reduces Prostate Cancer Cell Growth, But Does Not Modulate Daunorubicin or Cisplatin Cytotoxicity. , 2018, Oncology research.

[92]  R. Gillies,et al.  Carbonic anhydrase IX as an imaging and therapeutic target for tumors and metastases. , 2014, Sub-cellular biochemistry.

[93]  D. Zynger,et al.  Carbonic anhydrase IX is expressed in mesothelioma and metastatic clear cell renal cell carcinoma of the lung , 2011, Virchows Archiv.

[94]  Liu-zhen Xiao.  Relations of carbonic anhydrase-IX with tumorigenesis and metastasis of rectal cancer , 2011 .

[95]  S. Pastoreková,et al.  Tumor-associated carbonic anhydrases and their clinical significance. , 2006, Advances in clinical chemistry.

[96]  K. Wakasa,et al.  Histochemistry of tartrate-resistant acid phosphatase and carbonic anhydrase isoenzyme II in osteoclast-like giant cells in bone tumours , 2005, Virchows Archiv A.

[97]  H. Kasai,et al.  Potentiation of antitumor activity of 1-phthalidyl 5-fluorouracil by acetazolamide , 2004, Cancer Chemotherapy and Pharmacology.

[98]  M. Sheng.  Inhibition of AQP1 expression by acetazolamide and its relationship to intracellular pH and Ca~(2+) , 2003 .

[99]  B. Teicher,et al.  A carbonic anhydrase inhibitor as a potential modulator of cancer therapies. , 1993, Anticancer Research.