The LKB1 complex-AMPK pathway: the tree that hides the forest
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[1] D. St Johnston,et al. LKB1 and AMPK maintain epithelial cell polarity under energetic stress , 2013, The Journal of cell biology.
[2] Gerd Walz,et al. Primary cilia regulate mTORC1 activity and cell size through Lkb1 , 2010, Nature Cell Biology.
[3] M. Pellegrini,et al. AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling. , 2010, Molecular cell.
[4] A. Ashworth,et al. LKB1 Haploinsufficiency Cooperates With Kras to Promote Pancreatic Cancer Through Suppression of p21-Dependent Growth Arrest , 2010, Gastroenterology.
[5] A. Prescott,et al. New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion , 2010, Science Signaling.
[6] G. Rutter,et al. LKB1 deletion with the RIP2.Cre transgene modifies pancreatic β-cell morphology and enhances insulin secretion in vivo , 2010, American journal of physiology. Endocrinology and metabolism.
[7] J. Labbé,et al. Differential requirements for STRAD in LKB1-dependent functions in C. elegans , 2010, Development.
[8] N. Navaratnam,et al. Regulation of ploidy and senescence by the AMPK‐related kinase NUAK1 , 2010, The EMBO journal.
[9] Maria Deak,et al. Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation , 2009, Science.
[10] A. Ashworth,et al. Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation , 2009, The Journal of pathology.
[11] David K. Finlay,et al. LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells , 2009, European journal of immunology.
[12] M. Permutt,et al. LKB1 regulates pancreatic beta cell size, polarity, and function. , 2009, Cell metabolism.
[13] R. Shaw,et al. The LKB1–AMPK pathway: metabolism and growth control in tumour suppression , 2009, Nature Reviews Cancer.
[14] W. Hahn,et al. SIK1 Couples LKB1 to p53-Dependent Anoikis and Suppresses Metastasis , 2009, Science Signaling.
[15] P. Marignani,et al. LKB1 catalytic activity contributes to estrogen receptor alpha signaling. , 2009, Molecular biology of the cell.
[16] Y. Barral,et al. Septins and the lateral compartmentalization of eukaryotic membranes. , 2009, Developmental cell.
[17] L. Chin,et al. Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation. , 2009, Molecular cell.
[18] M. Schwartz,et al. Regulation of LKB1/STRAD Localization and Function by E-Cadherin , 2009, Current Biology.
[19] Fiona C. Denison,et al. Characterization of an Alternative Splice Variant of LKB1* , 2009, Journal of Biological Chemistry.
[20] D. Hardie,et al. C-terminal Phosphorylation of LKB1 Is Not Required for Regulation of AMP-activated Protein Kinase, BRSK1, BRSK2, or Cell Cycle Arrest* , 2009, Journal of Biological Chemistry.
[21] David M. A. Martin,et al. A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis. , 2008, The Biochemical journal.
[22] J. Bertoglio,et al. Rho-ROCK-Dependent Ezrin-Radixin-Moesin Phosphorylation Regulates Fas-Mediated Apoptosis in Jurkat Cells1 , 2008, The Journal of Immunology.
[23] N. Ruderman,et al. SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1 , 2008, Journal of Biological Chemistry.
[24] T. Ochiya,et al. Susceptibility of Snark‐deficient mice to azoxymethane‐induced colorectal tumorigenesis and the formation of aberrant crypt foci , 2008, Cancer science.
[25] A. Ashworth,et al. Lkb1 deficiency causes prostate neoplasia in the mouse. , 2008, Cancer research.
[26] I. Macara,et al. STRADalpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7. , 2008, Molecular biology of the cell.
[27] H. Tokumitsu,et al. Activation of SAD kinase by Ca2+/calmodulin-dependent protein kinase kinase. , 2008, Biochemistry.
[28] A. Marcus,et al. The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity. , 2008, Cancer research.
[29] Kwok-Kin Wong,et al. Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas. , 2008, Cancer research.
[30] Gerald C. Chu,et al. Pancreatic Lkb1 Deletion Leads to Acinar Polarity Defects and Cystic Neoplasms , 2008, Molecular and Cellular Biology.
[31] Y. Liao,et al. Identification of a novel substrate for TNFα-induced kinase NUAK2 , 2008 .
[32] M. Sanchez-Cespedes. A role for LKB1 gene in human cancer beyond the Peutz–Jeghers syndrome , 2007, Oncogene.
[33] P. Marignani,et al. Novel splice isoforms of STRADα differentially affect LKB1 activity, complex assembly and subcellular localization. , 2007, Cancer biology & therapy.
[34] H. Clevers,et al. Suppression of Tubulin Polymerization by the LKB1-Microtubule-associated Protein/Microtubule Affinity-regulating Kinase Signaling* , 2007, Journal of Biological Chemistry.
[35] David M Sabatini,et al. Defining the role of mTOR in cancer. , 2007, Cancer cell.
[36] D. St Johnston,et al. LKB1 and AMPK maintain epithelial cell polarity under energetic stress , 2007, The Journal of cell biology.
[37] J. Sanes,et al. LKB1 and SAD Kinases Define a Pathway Required for the Polarization of Cortical Neurons , 2007, Cell.
[38] Gordon B. Mills,et al. The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis , 2007, Nature Cell Biology.
[39] L. Cantley,et al. Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase , 2007, Proceedings of the National Academy of Sciences.
[40] M. Caplan,et al. AMP-activated protein kinase regulates the assembly of epithelial tight junctions , 2006, Proceedings of the National Academy of Sciences.
[41] Michael D. Schneider,et al. A pivotal role for endogenous TGF-β-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway , 2006, Proceedings of the National Academy of Sciences.
[42] S. Gruber,et al. Frequency and Spectrum of Cancers in the Peutz-Jeghers Syndrome , 2006, Clinical Cancer Research.
[43] R. DePinho,et al. The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin , 2005, Science.
[44] A. Prescott,et al. 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK , 2005, Journal of Cell Science.
[45] V. Launonen,et al. Mutations in the human LKB1/STK11 gene , 2005, Human mutation.
[46] A. Means,et al. The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases* , 2005, Journal of Biological Chemistry.
[47] A. Reymond,et al. LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes. , 2005, Human molecular genetics.
[48] Kei Sakamoto,et al. Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction , 2005, The EMBO journal.
[49] Hans Clevers,et al. Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity. , 2005, Human molecular genetics.
[50] D. Alessi,et al. Identification of the sucrose non‐fermenting related kinase SNRK, as a novel LKB1 substrate , 2005, FEBS letters.
[51] J. Sanes,et al. Mammalian SAD Kinases Are Required for Neuronal Polarization , 2005, Science.
[52] D. M. Glover,et al. Genome-wide survey of protein kinases required for cell cycle progression , 2004, Nature.
[53] A. Prescott,et al. Analysis of the LKB1-STRAD-MO25 complex , 2004, Journal of Cell Science.
[54] J. Yates,et al. The CREB Coactivator TORC2 Functions as a Calcium- and cAMP-Sensitive Coincidence Detector , 2004, Cell.
[55] H. Esumi,et al. Regulation of caspase-6 and FLIP by the AMPK family member ARK5 , 2004, Oncogene.
[56] A. Suzuki,et al. aPKC Acts Upstream of PAR-1b in Both the Establishment and Maintenance of Mammalian Epithelial Polarity , 2004, Current Biology.
[57] A. Merg,et al. Genetic conditions associated with intestinal juvenile polyps , 2004, American journal of medical genetics. Part C, Seminars in medical genetics.
[58] H. Esumi,et al. ARK5 Is a Tumor Invasion-Associated Factor Downstream of Akt Signaling , 2004, Molecular and Cellular Biology.
[59] P. Brennwald,et al. Mammalian PAR-1 determines epithelial lumen polarity by organizing the microtubule cytoskeleton , 2004, The Journal of cell biology.
[60] Jérôme Boudeau,et al. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1 , 2004, The EMBO journal.
[61] Hans C Clevers,et al. Complete Polarization of Single Intestinal Epithelial Cells upon Activation of LKB1 by STRAD , 2004, Cell.
[62] Gerhard Christofori,et al. Cell adhesion and signalling by cadherins and Ig-CAMs in cancer , 2004, Nature Reviews Cancer.
[63] D. Hardie,et al. CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations. , 2004, The Journal of clinical investigation.
[64] B. Evers,et al. Roles of Phosphatidylinositol 3′-Kinase and Mammalian Target of Rapamycin/p70 Ribosomal Protein S6 Kinase in K-Ras-Mediated Transformation of Intestinal Epithelial Cells , 2004, Cancer Research.
[65] M. Rossel,et al. Stability of the Peutz–Jeghers syndrome kinase LKB1 requires its binding to the molecular chaperones Hsp90/Cdc37 , 2003, Oncogene.
[66] David Carling,et al. Supplemental Data LKB 1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade , 2003 .
[67] E. Mandelkow,et al. MARKK, a Ste20‐like kinase, activates the polarity‐inducing kinase MARK/PAR‐1 , 2003, The EMBO journal.
[68] Hans Clevers,et al. MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm , 2003 .
[69] David Carling,et al. Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[70] H C Clevers,et al. Activation of the tumour suppressor kinase LKB1 by the STE20‐like pseudokinase STRAD , 2003, The EMBO journal.
[71] N. Horike,et al. Salt-inducible kinase-mediated regulation of steroidogenesis at the early stage of ACTH-stimulation , 2003, The Journal of Steroid Biochemistry and Molecular Biology.
[72] M. Lawlor,et al. Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability. , 2003, The Biochemical journal.
[73] Daniel St Johnston,et al. A role for Drosophila LKB1 in anterior–posterior axis formation and epithelial polarity , 2003, Nature.
[74] C. Smythe,et al. Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. , 2002, The Biochemical journal.
[75] Ronald A. DePinho,et al. Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation , 2002, Nature.
[76] Q. Deveraux,et al. ILPIP, a Novel Anti-apoptotic Protein That Enhances XIAP-mediated Activation of JNK1 and Protection against Apoptosis* , 2002, The Journal of Biological Chemistry.
[77] Z. Shao,et al. The tumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.
[78] T. Mäkelä,et al. Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1). , 2002, Human molecular genetics.
[79] G. Sapkota,et al. Identification and characterization of four novel phosphorylation sites (Ser 31 , Ser 325 , Thr 336 and Thr 366 ) on LKB1/STK11, the protein kinase mutated in Peutz–Jeghers cancer syndrome , 2022 .
[80] A. Ashworth,et al. LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1. , 2001, Human molecular genetics.
[81] F. Kanai,et al. LKB1 Associates with Brg1 and Is Necessary for Brg1-induced Growth Arrest* , 2001, The Journal of Biological Chemistry.
[82] K. Alitalo,et al. Vascular Abnormalities and Deregulation of VEGF in Lkb1-Deficient Mice , 2001, Science.
[83] L. Cantley,et al. The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. , 2001, Molecular cell.
[84] G. Sapkota,et al. Phosphorylation of the Protein Kinase Mutated in Peutz-Jeghers Cancer Syndrome, LKB1/STK11, at Ser431 by p90RSK and cAMP-dependent Protein Kinase, but Not Its Farnesylation at Cys433, Is Essential for LKB1 to Suppress Cell Growth* , 2001, The Journal of Biological Chemistry.
[85] G. Thomas,et al. Peutz-Jeghers families unlinked toSTK11/LKB1 gene mutations are highly predisposed to primitive biliary adenocarcinoma , 2001, Journal of medical genetics.
[86] S. Goodman,et al. Very high risk of cancer in familial Peutz-Jeghers syndrome. , 2000, Gastroenterology.
[87] R. Poulsom,et al. In situ analysis of LKB1/STK11 mRNA expression in human normal tissues and tumours , 2000, The Journal of pathology.
[88] M. Uhler,et al. LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo. , 2000, The Biochemical journal.
[89] J. Nezu,et al. Loss of cytoplasmic retention ability of mutant LKB1 found in Peutz-Jeghers syndrome patients. , 1999, Biochemical and biophysical research communications.
[90] T. Mäkelä,et al. Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[91] A. Ashworth,et al. The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase. , 1999, Human molecular genetics.
[92] A. Hemminki. The molecular basis and clinical aspects of Peutz-Jeghers syndrome , 1999, Cellular and Molecular Life Sciences CMLS.
[93] Gerhard Christofori,et al. A causal role for E-cadherin in the transition from adenoma to carcinoma , 1998, Nature.
[94] M. Stratton,et al. A serine/threonine kinase gene defective in Peutz–Jeghers syndrome , 1998, Nature.
[95] J. Maller,et al. Cloning and Characterization of a Novel Serine/Threonine Protein Kinase Expressed in Early Xenopus Embryos* , 1996, The Journal of Biological Chemistry.
[96] P. Fisher,et al. Cell cycle arrest. , 1995, Science.
[97] D. Morton,et al. Identification of genes required for cytoplasmic localization in early C. elegans embryos , 1988, Cell.
[98] David K. Finlay,et al. LKB 1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells , 2009 .
[99] E. Sahin,et al. LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis. , 2008, Cancer research.
[100] Y. Liao,et al. Identification of a novel substrate for TNFalpha-induced kinase NUAK2. , 2008, Biochemical and biophysical research communications.
[101] Alessandro Stella,et al. An LKB1 AT-AC intron mutation causes Peutz-Jeghers syndrome via splicing at noncanonical cryptic splice sites , 2005, Nature Structural &Molecular Biology.
[102] H. S. Kim,et al. Genetic analysis of the LKB1/STK11 gene in hepatocellular carcinomas. , 2004, European journal of cancer.
[103] Hans C Clevers,et al. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. , 2003, The EMBO journal.
[104] T. Mäkelä,et al. Growth arrest by the LKB 1 tumor suppressor : induction of p 21 WAF 1 / CIP 1 , 2002 .
[105] J. Nezu,et al. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. , 1998, Nature genetics.