Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression.

[1]  H. Broxmeyer,et al.  Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis , 2018, Nature Medicine.

[2]  S. Mattarollo,et al.  Natural killer cell metabolism. , 2017, Molecular immunology.

[3]  David K. Finlay,et al.  Srebp-controlled glucose metabolism is essential for NK cell functional responses , 2017, Nature Immunology.

[4]  N. Restifo,et al.  Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy. , 2017, Cell metabolism.

[5]  H. Ljunggren,et al.  Natural killer cell-mediated immunosurveillance of human cancer. , 2017, Seminars in immunology.

[6]  C. Leslie,et al.  Chromatin states define tumor-specific T cell dysfunction and reprogramming , 2017, Nature.

[7]  Benjamin D. Greenbaum,et al.  Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses , 2017, Cell.

[8]  David K. Finlay,et al.  What Fuels Natural Killers? Metabolism and NK Cell Responses , 2017, Front. Immunol..

[9]  P. Carmeliet,et al.  Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis. , 2016, Cell metabolism.

[10]  Camille Guillerey,et al.  Targeting natural killer cells in cancer immunotherapy , 2016, Nature Immunology.

[11]  Jeffrey J Delrow,et al.  Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis. , 2016, Immunity.

[12]  J. Rathmell,et al.  A guide to immunometabolism for immunologists , 2016, Nature Reviews Immunology.

[13]  Romina E Araya,et al.  NK Cells Restrain Spontaneous Antitumor CD8+ T Cell Priming through PD-1/PD-L1 Interactions with Dendritic Cells , 2016, The Journal of Immunology.

[14]  W. Yin,et al.  Liver-infiltrating CD11b−CD27− NK subsets account for NK-cell dysfunction in patients with hepatocellular carcinoma and are associated with tumor progression , 2016, Cellular and Molecular Immunology.

[15]  H. Honda,et al.  Decreased Expression of Fructose-1,6-bisphosphatase Associates with Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma. , 2016, Cancer research.

[16]  H. Ljunggren,et al.  Emerging insights into natural killer cells in human peripheral tissues , 2016, Nature Reviews Immunology.

[17]  S. Granjeaud,et al.  Inherent and Tumor-Driven Immune Tolerance in the Prostate Microenvironment Impairs Natural Killer Cell Antitumor Activity. , 2016, Cancer research.

[18]  Dongqing Xu,et al.  miR-146a negatively regulates NK cell functions via STAT1 signaling , 2016, Cellular &Molecular Immunology.

[19]  David K. Finlay,et al.  Metabolic Reprogramming Supports IFN-γ Production by CD56bright NK Cells , 2016, The Journal of Immunology.

[20]  Lewis L. Lanier,et al.  NK cells and cancer: you can teach innate cells new tricks , 2015, Nature Reviews Cancer.

[21]  S. Biswas.  Metabolic Reprogramming of Immune Cells in Cancer Progression. , 2015, Immunity.

[22]  M. Chew,et al.  The breast tumor microenvironment alters the phenotype and function of natural killer cells , 2015, Cellular and Molecular Immunology.

[23]  S. Varambally,et al.  Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction , 2015, Nature Immunology.

[24]  M. Cooper,et al.  Activation-Specific Metabolic Requirements for NK Cell IFN-γ Production , 2015, The Journal of Immunology.

[25]  David K. Finlay,et al.  mTORC1-Dependent Metabolic Reprogramming Is a Prerequisite for NK Cell Effector Function , 2014, The Journal of Immunology.

[26]  Kwok-Kin Wong,et al.  Non-small-cell lung cancers: a heterogeneous set of diseases , 2014, Nature Reviews Cancer.

[27]  J. Ochocki,et al.  Fructose-1, 6-bisphosphatase opposes renal carcinoma progression , 2014, Nature.

[28]  E. Gilson,et al.  The metabolic checkpoint kinase mTOR is essential for interleukin-15 signaling during NK cell development and activation , 2014, Nature Immunology.

[29]  Shohei Koyama,et al.  Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression. , 2014, Cancer cell.

[30]  V. Kuchroo,et al.  Reversal of NK-Cell Exhaustion in Advanced Melanoma by Tim-3 Blockade , 2014, Cancer Immunology Research.

[31]  M. Caligiuri,et al.  CS1-Specific Chimeric Antigen Receptor (CAR)-Engineered Natural Killer Cells Enhance In Vitro and In Vivo Anti-tumor Activity Against Human Multiple Myeloma , 2013, Leukemia.

[32]  K. Rabe,et al.  Management of non-small-cell lung cancer: recent developments , 2013, The Lancet.

[33]  J. Blay,et al.  Immune infiltrates are prognostic factors in localized gastrointestinal stromal tumors. , 2013, Cancer research.

[34]  Jun Yao,et al.  Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. , 2013, Cancer cell.

[35]  T. Stinchcombe,et al.  KRAS mutation: should we test for it, and does it matter? , 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[36]  D. Noonan,et al.  The proangiogenic phenotype of natural killer cells in patients with non-small cell lung cancer. , 2013, Neoplasia.

[37]  R. Sun,et al.  Lung natural killer cells in mice: phenotype and response to respiratory infection , 2012, Immunology.

[38]  C. Drake,et al.  Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. , 2012, The New England journal of medicine.

[39]  David C. Smith,et al.  Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. , 2012, The New England journal of medicine.

[40]  C. Sautès-Fridman,et al.  The immune contexture in human tumours: impact on clinical outcome , 2012, Nature Reviews Cancer.

[41]  F. Bertucci,et al.  Human breast tumor cells induce self-tolerance mechanisms to avoid NKG2D-mediated and DNAM-mediated NK cell recognition. , 2011, Cancer research.

[42]  Ning Li,et al.  Promoter Hypermethylation Mediated Downregulation of FBP1 in Human Hepatocellular Carcinoma and Colon Cancer , 2011, PloS one.

[43]  P. Validire,et al.  Profound coordinated alterations of intratumoral NK cell phenotype and function in lung carcinoma. , 2011, Cancer research.

[44]  S. Rosenberg,et al.  Adoptive Transfer of Autologous Natural Killer Cells Leads to High Levels of Circulating Natural Killer Cells but Does Not Mediate Tumor Regression , 2011, Clinical Cancer Research.

[45]  Kwang Dong Kim,et al.  L-kynurenine-induced apoptosis in human NK cells is mediated by reactive oxygen species. , 2011, International immunopharmacology.

[46]  M. Caligiuri,et al.  The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody. , 2010, Blood.

[47]  Richard A. Flavell,et al.  The polarization of immune cells in the tumour environment by TGFβ , 2010, Nature Reviews Immunology.

[48]  F. Culley.  Natural killer cells in infection and inflammation of the lung , 2009, Immunology.

[49]  T. Jacks,et al.  Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase , 2009, Nature Protocols.

[50]  Eric Vivier,et al.  Functions of natural killer cells , 2008, Nature Immunology.

[51]  G. Altavilla,et al.  Natural killer cells infiltrating human nonsmall‐cell lung cancer are enriched in CD56brightCD16− cells and display an impaired capability to kill tumor cells , 2008, Cancer.

[52]  F. Geissmann,et al.  The trafficking of natural killer cells , 2007, Immunological reviews.

[53]  yang-xin fu,et al.  NK-cell activation by LIGHT triggers tumor-specific CD8+ T-cell immunity to reject established tumors. , 2006, Blood.

[54]  L. Zitvogel,et al.  Trial Watch , 2005 .

[55]  Tao Jiang,et al.  MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[56]  R. Schreiber,et al.  Cancer immunoediting: from immunosurveillance to tumor escape , 2002, Nature Immunology.

[57]  Kazuyoshi Takeda,et al.  New aspects of natural-killer-cell surveillance and therapy of cancer , 2002, Nature Reviews Cancer.

[58]  G. Vawter,et al.  INVESTIGATION OF INBORN ERRORS OF METABOLISM IN UNEXPECTED INFANT DEATHS , 1988, The Lancet.

[59]  R. Crystal,et al.  Natural killer cells are present in the normal human lung but are functionally impotent. , 1984, The Journal of clinical investigation.

[60]  CONTACT FOR REAGENT AND RESOURCE SHARING , 2018 .

[61]  A. Jemal,et al.  Cancer statistics, 2012 , 2012, CA: a cancer journal for clinicians.

[62]  U. Mellqvist,et al.  Natural killer cell dysfunction and apoptosis induced by chronic myelogenous leukemia cells: role of reactive oxygen species and regulation by histamine. , 2000, Blood.