Computational Thermodynamics Analysis of Vaporizing Fuel Droplets in the Human Upper Airways

The detailed knowledge of air flow structures as well as particle transport and deposition in the human lung for typical inhalation flow rates is an important precursor for dosimetry-and-health-effect studies of toxic particles as well as for targeted drug delivery of therapeutic aerosols. Focusing on highly toxic JP-8 fuel aerosols, 3-D airflow and fluid-particle thermodynamics in a human upper airway model starting from mouth to Generation G3 (G0 is the trachea) are simulated using a user-enhanced and experimentally validated finite-volume code. The temperature distributions and their effects on airflow structures, fuel vapor deposition and droplet motion/evaporation are discussed. The computational results show that the thermal effect on vapor deposition is minor, but it may greatly affect droplet deposition in human airways.

[1]  Clement Kleinstreuer,et al.  Flow structures and particle deposition patterns in double-bifurcation airway models. Part 1. Air flow fields , 2001, Journal of Fluid Mechanics.

[2]  B. Cohen,et al.  The deposition of unattached radon progeny in a tracheobronchial cast as measured with iodine vapor , 1998 .

[3]  Clement Kleinstreuer,et al.  Laminar-to-turbulent fluid-particle flows in a human airway model , 2003 .

[4]  A. Benaissa,et al.  Modelling evaporation of multicomponent fuel droplets under ambient temperature conditions , 2002 .

[5]  Clement Kleinstreuer,et al.  Cyclic micron-size particle inhalation and deposition in a triple bifurcation lung airway model , 2002 .

[6]  A. Gosman,et al.  Aspects of Computer Simulation of Liquid-Fueled Combustors , 1983 .

[7]  Sanford D Zelnick,et al.  Personal exposure to JP-8 jet fuel vapors and exhaust at air force bases. , 2000, Environmental health perspectives.

[8]  Clement Kleinstreuer,et al.  Low-Reynolds-Number Turbulent Flows in Locally Constricted Conduits: A Comparison Study , 2003 .

[9]  E. Weibel.  Morphometry of the Human Lung , 1965, Springer Berlin Heidelberg.

[10]  A. Gosman,et al.  Aspects of computer simulation of liquid-fuelled combustors , 1981 .

[11]  Thomas Heistracher,et al.  Computation of local enhancement factors for the quantification of particle deposition patterns in airway bifurcations , 1999 .

[12]  D. Wilcox.  Turbulence modeling for CFD , 1993 .

[13]  G. Yu,et al.  Fluid Flow and Particle Diffusion in the Human Upper Respiratory System , 1998 .

[14]  Clement Kleinstreuer,et al.  Transient airflow structures and particle transport in a sequentially branching lung airway model , 2002 .

[15]  Morrison Ir.  Functional anatomy of the upper airway. , 1988 .

[16]  Y. Cheng,et al.  Measurements of airway dimensions and calculation of mass transfer characteristics of the human oral passage. , 1997, Journal of biomechanical engineering.