Effect of MR Distortion on Targeting for Deep-Brain Stimulation

Deep-brain stimulation (DBS) surgery involves placing electrodes within specific deep-brain target nuclei. Surgeons employ MR imaging for preoperative selection of targets and computed tomography (CT) imaging for designing stereotactic frames used for intraoperative placement of electrodes at the targets. MR distortion may contribute to target-selection error in the MR scan and also to MR-CT registration error, each of which contributes to error in electrode placement. In this paper, we analyze the error contributed by the MR distortion to the total DBS targeting error. Distortion in conventional MR scans, both T1 and T2 weighted, were analyzed for six bilateral DBS patients in the typical areas of brain using typical scans on a 3-T clinical scanner. Mean targeting error due to MR distortion in T2 was found to be 0.07 ± 0.025 mm with a maximum of 0.13 mm over 12 targets; error in the T1 images was smaller by 4%.

[1]  Benoit M. Dawant,et al.  Clinical Accuracy of a Customized Stereotactic Platform for Deep Brain Stimulation after Accounting for Brain Shift , 2010, Stereotactic and Functional Neurosurgery.

[2]  Robert E. Gross,et al.  Assessment of Brain Shift Related to Deep Brain Stimulation Surgery , 2007, Stereotactic and Functional Neurosurgery.

[3]  J. Henderson,et al.  The application accuracy of a skull-mounted trajectory guide system for image-guided functional neurosurgery , 2004, Computer aided surgery : official journal of the International Society for Computer Aided Surgery.

[4]  J. Henderson,et al.  Frameless stereotaxy using bone fiducial markers for deep brain stimulation. , 2005, Journal of neurosurgery.

[5]  Max A. Viergever,et al.  Mutual-information-based registration of medical images: a survey , 2003, IEEE Transactions on Medical Imaging.

[6]  R. Maciunas,et al.  The application accuracy of stereotactic frames. , 1994, Neurosurgery.

[7]  Benoit M. Dawant,et al.  The adaptive bases algorithm for intensity-based nonrigid image registration , 2003, IEEE Transactions on Medical Imaging.

[8]  Gerald Q. Maguire,et al.  Comparison and evaluation of retrospective intermodality brain image registration techniques. , 1997, Journal of computer assisted tomography.

[9]  J. Fitzpatrick,et al.  Accuracy of Customized Miniature Stereotactic Platforms , 2005, Stereotactic and Functional Neurosurgery.

[10]  H. Bjartmarz,et al.  Comparison of Accuracy and Precision between Frame-Based and Frameless Stereotactic Navigation for Deep Brain Stimulation Electrode Implantation , 2007, Stereotactic and Functional Neurosurgery.

[11]  Benoit M. Dawant,et al.  Accuracy Evaluation of microTargeting Platforms for Deep-Brain Stimulation Using Virtual Targets , 2009, IEEE Transactions on Biomedical Engineering.