HMGB1-DNA complex-induced autophagy limits AIM2 inflammasome activation through RAGE.

[1]  Jacob D. Jaffe,et al.  Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense , 2014, Proceedings of the National Academy of Sciences.

[2]  Xiaorong Zhu,et al.  Hepatocyte‐specific high‐mobility group box 1 deletion worsens the injury in liver ischemia/reperfusion: A role for intracellular high‐mobility group box 1 in cellular protection , 2014, Hepatology.

[3]  K. Tracey,et al.  Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice. , 2014, Gastroenterology.

[4]  T. Taniguchi,et al.  Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection , 2013, Proceedings of the National Academy of Sciences.

[5]  M. Lotze,et al.  Strange attractors: DAMPs and autophagy link tumor cell death and immunity , 2013, Cell Death and Disease.

[6]  E. Latz,et al.  RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA , 2013, The Journal of experimental medicine.

[7]  M. Lotze,et al.  HMGB1 in Cancer: Good, Bad, or Both? , 2013, Clinical Cancer Research.

[8]  M. Lotze,et al.  DAMPs and autophagy , 2013, Autophagy.

[9]  D. Tang,et al.  PKR-Dependent Inflammatory Signals , 2012, Science Signaling.

[10]  M. Lotze,et al.  PAMPs and DAMPs: signal 0s that spur autophagy and immunity , 2012, Immunological reviews.

[11]  K. Tracey,et al.  Novel role of PKR in inflammasome activation and HMGB1 release , 2012, Nature.

[12]  Simon C Watkins,et al.  p53/HMGB1 complexes regulate autophagy and apoptosis. , 2012, Cancer research.

[13]  A. Sher,et al.  Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction , 2012, Nature Immunology.

[14]  V. Deretic,et al.  Autophagy‐based unconventional secretory pathway for extracellular delivery of IL‐1β , 2011, The EMBO journal.

[15]  M. Lotze,et al.  High mobility group box 1 (HMGB1) activates an autophagic response to oxidative stress. , 2011, Antioxidants & redox signaling.

[16]  K. Tracey,et al.  EGCG stimulates autophagy and reduces cytoplasmic HMGB1 levels in endotoxin-stimulated macrophages. , 2011, Biochemical pharmacology.

[17]  K. Tracey,et al.  HMGB1 is a therapeutic target for sterile inflammation and infection. , 2011, Annual review of immunology.

[18]  H. Virgin,et al.  Autophagy in immunity and inflammation , 2011, Nature.

[19]  J. Tschopp,et al.  Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation , 2011, The Journal of Biological Chemistry.

[20]  S. Ryter,et al.  Autophagy proteins regulate innate immune response by inhibiting NALP3 inflammasome-mediated mitochondrial DNA release , 2010, Nature Immunology.

[21]  G. Kroemer,et al.  Autophagy and the integrated stress response. , 2010, Molecular cell.

[22]  K. Tracey,et al.  Endogenous HMGB1 regulates autophagy , 2010, The Journal of cell biology.

[23]  K. Tracey,et al.  HMGB1 Release and Redox Regulates Autophagy and Apoptosis in Cancer Cells , 2010, Oncogene.

[24]  Pengyuan Yang,et al.  The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a β-catenin-dependent pathway , 2010, Nature Immunology.

[25]  L. Zitvogel,et al.  Decoding Cell Death Signals in Inflammation and Immunity , 2010, Cell.

[26]  S. Akira,et al.  HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses , 2009, Nature.

[27]  M. Bianchi,et al.  HMGB1 loves company , 2009, Journal of leukocyte biology.

[28]  E. Alnemri,et al.  AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA , 2009, Nature.

[29]  Daniel R. Caffrey,et al.  AIM2 recognizes cytosolic dsDNA and forms a caspase-1 activating inflammasome with ASC , 2009, Nature.

[30]  S. Akira,et al.  Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production , 2008, Nature.

[31]  K. Honda,et al.  DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response , 2007, Nature.

[32]  L. Audoly,et al.  Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE , 2007, Nature Immunology.

[33]  Haichao Wang,et al.  A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA. , 2007, Blood.

[34]  D. Angus,et al.  Circulating high-mobility group box 1 (HMGB1) concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsis* , 2007, Critical care medicine.

[35]  Kevin J. Tracey,et al.  High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal , 2005, Nature Reviews Immunology.

[36]  E. Schleicher,et al.  Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response. , 2004, The Journal of clinical investigation.

[37]  T. Misteli,et al.  Release of chromatin protein HMGB1 by necrotic cells triggers inflammation , 2002, Nature.

[38]  S. Knapp,et al.  Thermodynamics of HMGB1 interaction with duplex DNA. , 2001, Biochemistry.

[39]  S. Emr,et al.  Autophagy as a regulated pathway of cellular degradation. , 2000, Science.

[40]  Takeshi Noda,et al.  LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing , 2000, The EMBO journal.

[41]  K. Tracey,et al.  HMG-1 as a late mediator of endotoxin lethality in mice. , 1999, Science.

[42]  D. Tang,et al.  HMGB1 promotes drug resistance in osteosarcoma. , 2012, Cancer research.

[43]  M. Lotze,et al.  HMGB1-induced autophagy promotes chemotherapy resistance in leukemia cells , 2011, Leukemia.

[44]  J. Tschopp,et al.  The Inflammasomes , 2010, Cell.

[45]  Hong Wang,et al.  Structural Basis for the Proinflammatory Cytokine Activity of High Mobility Group Box 1 , 2003, Molecular medicine.