Advances in portable electrospinning devices for in situ delivery of personalized wound care.

Electrospinning and electrospun fibrous assemblies have attracted interest in a variety of biomedical fields including woundcare, tissue engineering and drug delivery, due to the large surface-area-to-volume ratio and high porosity of nanofibrous webs. Normally, wound dressings are manufactured well before the point of care, and then packaged and distributed for use at a later stage. More recently, in situ electrospinning of fibers directly onto wound sites has been proposed as a route to personalized wound dressing manufacture, tailored to the needs of individual patients. Practically, in situ deposition of nanofibers on to a wound could be envisaged using a portable or hand-held electrospinning device that is safe and easy to operate. This review focuses on recent advances in portable electrospinning technology and potential applications in woundcare and regenerative medicine. The main research challenges and future trends are also considered.

[1]  Richard A. Vaia,et al.  Generation of electrospun fibers of nylon 6 and nylon 6-montmorillonite nanocomposite , 2002 .

[2]  R. Spretz,et al.  Use of Coaxial Gas Jackets to Stabilize Taylor Cones of Volatile Solutions and to Induce Particle‐to‐Fiber Transitions , 2004 .

[3]  Yun-Ze Long,et al.  In situ deposition of a personalized nanofibrous dressing via a handy electrospinning device for skin wound care. , 2016, Nanoscale.

[4]  Younan Xia,et al.  Direct Fabrication of Composite and Ceramic Hollow Nanofibers by Electrospinning , 2004 .

[5]  Geoffrey Ingram Taylor,et al.  Disintegration of water drops in an electric field , 1964, Proceedings of the Royal Society of London. Series A. Mathematical and Physical Sciences.

[6]  Fang-Fang Yan,et al.  In Situ Electrospinning Iodine-Based Fibrous Meshes for Antibacterial Wound Dressing , 2018, Nanoscale Research Letters.

[7]  Andreas Greiner,et al.  Electrospinning: a fascinating method for the preparation of ultrathin fibers. , 2007, Angewandte Chemie.

[8]  Y. Huang,et al.  Fabrication of curled conducting polymer microfibrous arrays via a novel electrospinning method for stretchable strain sensors. , 2013, Nanoscale.

[9]  H Zhao,et al.  A battery-operated portable handheld electrospinning apparatus. , 2015, Nanoscale.

[10]  Martin Möller,et al.  Electrospinning with dual collection rings , 2005 .

[11]  S. Kundu,et al.  Electrospinning: a fascinating fiber fabrication technique. , 2010, Biotechnology advances.

[12]  Y. Long,et al.  Simple piezoelectric ceramic generator-based electrospinning apparatus , 2016 .

[13]  A. Jayakrishnan,et al.  Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin. , 2005, Biomaterials.

[14]  D. Reneker,et al.  Nanometre diameter fibres of polymer, produced by electrospinning , 1996 .

[15]  P. Mouthuy,et al.  Performances of a portable electrospinning apparatus , 2015, Biotechnology Letters.

[16]  Darrell H. Reneker,et al.  Bending instability of electrically charged liquid jets of polymer solutions in electrospinning , 2000 .

[17]  P. Mouthuy,et al.  Direct electrospinning of poly(vinyl butyral) onto human dermal fibroblasts using a portable device , 2018, Biotechnology Letters.

[18]  M. Edirisinghe,et al.  A portable device for in situ deposition of bioproducts , 2014 .

[19]  G. Taylor.  Studies in electrohydrodynamics. I. The circulation produced in a drop by an electric field , 1966, Proceedings of the Royal Society of London. Series A. Mathematical and Physical Sciences.

[20]  Y. Huang,et al.  Colorful Hydrophobic Poly(Vinyl Butyral)/Cationic Dye Fibrous Membranes via a Colored Solution Electrospinning Process , 2016, Nanoscale Research Letters.

[21]  Jiang Chang,et al.  Controlled drug release from a polymer matrix by patterned electrospun nanofibers with controllable hydrophobicity. , 2013, Journal of materials chemistry. B.

[22]  Nicole E. Zander,et al.  Hierarchically Structured Electrospun Fibers , 2013 .

[23]  Elisa Mele,et al.  Electrospinning of natural polymers for advanced wound care: towards responsive and adaptive dressings. , 2016, Journal of materials chemistry. B.

[24]  C. Angammana,et al.  Fundamentals of electrospinning and processing technologies , 2016 .

[25]  Y. Long,et al.  Electric- Field-Modified In Situ Precise Deposition of Electrospun Medical Glue Fibers on the Liver for Rapid Hemostasis , 2018, Nanoscale Research Letters.

[26]  Miao Yu,et al.  Patterned, highly stretchable and conductive nanofibrous PANI/PVDF strain sensors based on electrospinning and in situ polymerization. , 2016, Nanoscale.

[27]  Pedro L Granja,et al.  Advanced biofabrication strategies for skin regeneration and repair. , 2013, Nanomedicine.

[28]  Geoffrey Ingram Taylor,et al.  Electrically driven jets , 1969, Proceedings of the Royal Society of London. A. Mathematical and Physical Sciences.

[29]  Y. Long,et al.  Recent Advances in Needleless Electrospinning of Ultrathin Fibers: From Academia to Industrial Production , 2017 .

[30]  B. Ding,et al.  Ultra-light 3D nanofibre-nets binary structured nylon 6–polyacrylonitrile membranes for efficient filtration of fine particulate matter , 2015 .

[31]  David G Simpson,et al.  Electrospinning of collagen nanofibers. , 2002, Biomacromolecules.

[32]  Younan Xia,et al.  Electrospinning Nanofibers as Uniaxially Aligned Arrays and Layer‐by‐Layer Stacked Films , 2004 .

[33]  Yun-Ze Long,et al.  Electrospun Aligned Fibrous Arrays and Twisted Ropes: Fabrication, Mechanical and Electrical Properties, and Application in Strain Sensors , 2015, Nanoscale Research Letters.

[34]  P. Bártolo,et al.  Advances in electrospun skin substitutes , 2016 .

[35]  M. Kotaki,et al.  A review on polymer nanofibers by electrospinning and their applications in nanocomposites , 2003 .

[36]  Geunhyung Kim,et al.  Apparatus for preparing electrospun nanofibers: designing an electrospinning process for nanofiber fabrication , 2007 .

[37]  Younan Xia,et al.  Electrospinning of Nanofibers: Reinventing the Wheel? , 2004 .

[38]  M. Cai,et al.  Efficient Synthesis of PVDF/PI Side-by-Side Bicomponent Nanofiber Membrane with Enhanced Mechanical Strength and Good Thermal Stability , 2018, Nanomaterials.

[39]  Yun-Ze Long,et al.  In situ precise electrospinning of medical glue fibers as nonsuture dural repair with high sealing capability and flexibility , 2016, International journal of nanomedicine.

[40]  Jun Kameoka,et al.  A scanning tip electrospinning source for deposition of oriented nanofibres , 2003 .

[41]  Portable melt electrospinning apparatus without an extra electricity supply , 2017 .

[42]  R. Kornhaber,et al.  The Feasibility of a Handheld Electrospinning Device for the Application of Nanofibrous Wound Dressings. , 2017, Advances in wound care.

[43]  Yun-Ze Long,et al.  Melt electrospinning of poly(lactic acid) and polycaprolactone microfibers by using a hand-operated Wimshurst generator. , 2015, Nanoscale.

[44]  Y. Long,et al.  Colorimetric Humidity Sensors Based on Electrospun Polyamide/CoCl2 Nanofibrous Membranes , 2017, Nanoscale Research Letters.

[45]  Long Lin,et al.  Grating‐Structured Freestanding Triboelectric‐Layer Nanogenerator for Harvesting Mechanical Energy at 85% Total Conversion Efficiency , 2014, Advanced materials.

[46]  H. Santos,et al.  Electrospun Photocrosslinkable Hydrogel Fibrous Scaffolds for Rapid In Vivo Vascularized Skin Flap Regeneration , 2017 .

[47]  Y. Long,et al.  A portable electrospinning apparatus based on a small solar cell and a hand generator: design, performance and application. , 2016, Nanoscale.

[48]  M. Edirisinghe,et al.  An Inexpensive, Portable Device for Point‐of‐Need Generation of Silver‐Nanoparticle Doped Cellulose Acetate Nanofibers for Advanced Wound Dressing , 2018 .

[49]  George G. Chase,et al.  Continuous Electrospinning of Aligned Polymer Nanofibers onto a Wire Drum Collector , 2004 .

[50]  Zhiyong Fan,et al.  A calibration-free self-powered sensor for vital sign monitoring and finger tap communication based on wearable triboelectric nanogenerator , 2019, Nano Energy.

[51]  Darrell H. Reneker,et al.  Electrospinning process and applications of electrospun fibers , 1995 .

[52]  Jianjun Luo,et al.  Self-Powered Electrospinning System Driven by a Triboelectric Nanogenerator. , 2017, ACS nano.

[53]  Bin Sun,et al.  Recent advances in flexible and stretchable electronic devices via electrospinning , 2014 .

[54]  H Zhao,et al.  Chitosan nanostructures by in situ electrospinning for high-efficiency PM2.5 capture. , 2017, Nanoscale.

[55]  Tao Jiang,et al.  Structural Optimization of Triboelectric Nanogenerator for Harvesting Water Wave Energy. , 2015, ACS nano.

[56]  Andreas Greiner,et al.  Compound Core–Shell Polymer Nanofibers by Co‐Electrospinning , 2003 .

[57]  Ioannis S. Chronakis,et al.  Novel nanocomposites and nanoceramics based on polymer nanofibers using electrospinning process—A review , 2005 .

[58]  Zhong Lin Wang.  Triboelectric nanogenerators as new energy technology for self-powered systems and as active mechanical and chemical sensors. , 2013, ACS nano.

[59]  Y. Huang,et al.  Airflow-directed in situ electrospinning of a medical glue of cyanoacrylate for rapid hemostasis in liver resection. , 2014, Nanoscale.

[60]  Darrell H. Reneker,et al.  DNA fibers by electrospinning , 1997 .

[61]  Yun-Ze Long,et al.  Advances in three-dimensional nanofibrous macrostructures via electrospinning , 2014 .

[62]  Y. Long,et al.  Flexible inorganic core-shell nanofibers endowed with tunable multicolor upconversion fluorescence for simultaneous monitoring dual drug delivery , 2018, Chemical Engineering Journal.

[63]  Y. Huang,et al.  Self-powered electrospinning apparatus based on a hand-operated Wimshurst generator. , 2015, Nanoscale.

[64]  Jiang Chang,et al.  Patterning of Electrospun Fibers Using Electroconductive Templates , 2007 .

[65]  Liwei Lin,et al.  Near-field electrospinning. , 2006, Nano letters.

[66]  Younan Xia,et al.  Electrospinning of polymeric and ceramic nanofibers as uniaxially aligned arrays , 2003 .

[67]  H. Santos,et al.  Electrospun Fibrous Architectures for Drug Delivery, Tissue Engineering and Cancer Therapy , 2018, Advanced Functional Materials.

[68]  Zhiyong Fan,et al.  Recent advances in large-scale assembly of semiconducting inorganic nanowires and nanofibers for electronics, sensors and photovoltaics. , 2012, Chemical Society reviews.

[69]  S. Ramakrishna,et al.  A review on electrospinning design and nanofibre assemblies , 2006, Nanotechnology.

[70]  Nripan Mathews,et al.  High efficiency electrospun TiO₂ nanofiber based hybrid organic-inorganic perovskite solar cell. , 2014, Nanoscale.

[71]  Xin Ning,et al.  Reversible photochromic nanofibrous membranes with excellent water/windproof and breathable performance , 2018 .

[72]  Y. Long,et al.  In situ precision electrospinning as an effective delivery technique for cyanoacrylate medical glue with high efficiency and low toxicity. , 2015, Nanoscale.

[73]  Ce Wang,et al.  Electrospun Nanomaterials for Supercapacitor Electrodes: Designed Architectures and Electrochemical Performance , 2017 .

[74]  Zhiyong Fan,et al.  Bionic Single-Electrode Electronic Skin Unit Based on Piezoelectric Nanogenerator. , 2018, ACS nano.

[75]  Jingwei Xie,et al.  Recent advances in electrospun nanofibers for wound healing. , 2017, Nanomedicine.

[76]  Eleanor Stride,et al.  Design, construction and performance of a portable handheld electrohydrodynamic multi-needle spray gun for biomedical applications. , 2013, Materials science & engineering. C, Materials for biological applications.

[77]  Xilin Li,et al.  From nano to micro to macro: Electrospun hierarchically structured polymeric fibers for biomedical applications , 2017, Progress in Polymer Science.

[78]  Bin Ding,et al.  Electrospun nanomaterials for ultrasensitive sensors , 2010, Materials Today.

[79]  Darrell H. Reneker,et al.  Beaded nanofibers formed during electrospinning , 1999 .

[80]  Seyed Hassan Jafari,et al.  A review on wound dressings with an emphasis on electrospun nanofibrous polymeric bandages , 2010 .

[81]  S. Ramakrishna,et al.  Electric Field-Assisted In Situ Precise Deposition of Electrospun γ-Fe2O3/Polyurethane Nanofibers for Magnetic Hyperthermia , 2018, Nanoscale Research Letters.