论文信息 - The Flip Side of Synapse Elimination

The Flip Side of Synapse Elimination

The fine tuning of synaptic circuits often requires an activity-dependent phase in which appropriate connections are strengthened and inappropriate connections are eliminated. In this issue of Neuron, Walsh and Lichtman propose a novel "synaptic takeover" mechanism for synapse elimination at the vertebrate NMJ, where withdrawal of one axon is accompanied by expansion of a competing axon into the newly vacated territory.

Karen Zito | K. Zito

[1] B. Zemelman,et al. Genetic schemes and schemata in neurophysiology , 2001, Current Opinion in Neurobiology.

[2] J. Lichtman,et al. Synapse Elimination and Indelible Memory , 2000, Neuron.

[3] J. Sanes,et al. Development of the vertebrate neuromuscular junction. , 1999, Annual review of neuroscience.

[4] J. Lichtman,et al. In Vivo Time-Lapse Imaging of Synaptic Takeover Associated with Naturally Occurring Synapse Elimination , 2003, Neuron.

[5] Susanne E. Ahmari,et al. Assembly of presynaptic active zones from cytoplasmic transport packets , 2000, Nature Neuroscience.

[6] G. Fischbach,et al. Neuregulin and ErbB receptor signaling pathways in the nervous system , 2001, Current Opinion in Neurobiology.

[7] S. Burden. Building the vertebrate neuromuscular synapse. , 2002, Journal of neurobiology.

[8] G. Feng,et al. Asynchronous Synapse Elimination in Neonatal Motor Units Studies Using GFP Transgenic Mice , 2001, Neuron.

[9] Charles Jennings,et al. Death of a synapse , 1994, Nature.

[10] Scott E. Fraser,et al. Rapid remodeling of retinal arbors in the tectum with and without blockade of synaptic transmission , 1994, Neuron.

[11] Jeff W. Lichtman,et al. Long-term synapse loss induced by focal blockade of postsynaptlc receptors , 1994, Nature.

[12] E. Costanzo,et al. Co‐regulation of synaptic efficacy at stable polyneuronally innervated neuromuscular junctions in reinnervated rat muscle , 1999, The Journal of physiology.