The prognostic value of TCF1+CD8+T in primary small cell carcinoma of the esophagus

TCF1+CD8+T cells are reported to exhibit stem‐like properties with the ability to self‐renew and differentiate into terminal effector T cells (TCF1‐CD8+T cells) to enhance antitumor response. Previous studies indicated that TCF1+CD8+ tumor‐infiltrating lymphocytes (TILs) are related to response to immunotherapy. However, their role in predicting prognosis for patients with primary small cell carcinoma of the esophagus (PSCCE) remains unclear. In this study, the expression of TCF1+CD8+T was analyzed by multiplex fluorescence immunohistochemistry in tumor tissues of 79 patients with PSCCE. High infiltration of TCF1+CD8+T cells had longer overall survival (OS) than low infiltration (P = .009, hazard ratio [HR] = 0.506). High TCF1+CD8/CD8 ratio (>21%) showed superior OS compared with low ratio (≤21%) (P < .001, HR = 0.394). In the validation set (n = 20), the prognostic value of TCF1+CD8+T cells on OS was also verified. TCF1+CD8+T cells are strong prognostic predictors.

[1]  Tracey F Lee-Pullen,et al.  PD‐L1+ dendritic cells in the tumor microenvironment correlate with good prognosis and CD8+ T cell infiltration in colon cancer , 2020, Cancer science.

[2]  G. Altan-Bonnet,et al.  Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer , 2020, Science.

[3]  M. Delorenzi,et al.  Central memory CD8+ T cells derive from stem-like Tcf7hi effector cells in the absence of cytotoxic differentiation. , 2020, Immunity.

[4]  T. MacDonald,et al.  Subtype and grade-dependent spatial heterogeneity of T-cell infiltration in pediatric glioma , 2020, Journal for ImmunoTherapy of Cancer.

[5]  Renquan Zhang,et al.  Primary small cell carcinoma of the esophagus: progression in the last decade , 2020, Annals of translational medicine.

[6]  L. Mielke,et al.  Control of Lymphocyte Fate, Infection, and Tumor Immunity by TCF-1. , 2019, Trends in immunology.

[7]  D. Speiser,et al.  Intratumoral CD8+ T cells with stem cell–like properties: Implications for cancer immunotherapy , 2019, Science Translational Medicine.

[8]  C. Wurmser,et al.  Proliferation-competent Tcf1+ CD8 T cells in dysfunctional populations are CD4 T cell help independent , 2019, Proceedings of the National Academy of Sciences.

[9]  F. Hodi,et al.  Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade , 2019, Nature Immunology.

[10]  Daniel E. Speiser,et al.  Intratumoral Tcf1+PD‐1+CD8+ T Cells with Stem‐like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy , 2019, Immunity.

[11]  Paul J. Hoover,et al.  Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma , 2018, Cell.

[12]  M. Fehlings,et al.  Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates , 2018, Nature.

[13]  R. Pierce,et al.  PD-1 Expression in Head and Neck Squamous Cell Carcinomas Derives Primarily from Functionally Anergic CD4+ TILs in the Presence of PD-L1+ TAMs. , 2017, Cancer research.

[14]  Y. Maehara,et al.  The prognostic impact of programmed cell death ligand 1 and human leukocyte antigen class I in pancreatic cancer , 2017, Cancer medicine.

[15]  A. Bhandoola,et al.  CD8+ T Lymphocyte Self-Renewal during Effector Cell Determination. , 2016, Cell reports.

[16]  Ting Ni,et al.  Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection , 2016, Nature.

[17]  Sandra P. Calderon-Copete,et al.  T Cell Factor 1-Expressing Memory-like CD8(+) T Cells Sustain the Immune Response to Chronic Viral Infections. , 2016, Immunity.

[18]  M. Berger,et al.  Expression and prognostic impact of immune modulatory molecule PD-L1 in meningioma , 2015, Journal of Neuro-Oncology.

[19]  J. Aster,et al.  T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling , 2011, Proceedings of the National Academy of Sciences.

[20]  G. Kroemer,et al.  Prognostic and predictive impact of intra- and peritumoral immune infiltrates. , 2011, Cancer research.

[21]  K. Campbell,et al.  Structure/function of human killer cell immunoglobulin‐like receptors: lessons from polymorphisms, evolution, crystal structures and mutations , 2011, Immunology.

[22]  Federica Cavallo,et al.  2011: the immune hallmarks of cancer , 2011, Cancer Immunology, Immunotherapy.

[23]  H. Fujii,et al.  Downregulation of HLA Class I molecules in the tumour is associated with a poor prognosis in patients with oesophageal squamous cell carcinoma , 2008, British Journal of Cancer.

[24]  S. Kitano,et al.  Clinical significance of HLA class I heavy chain expression in patients with gastric cancer , 2008, Journal of surgical oncology.

[25]  M. Nishimura,et al.  HLA class I antigen expression is associated with a favorable prognosis in early stage non‐small cell lung cancer , 2007, Cancer science.

[26]  L. Zitvogel,et al.  Cancer despite immunosurveillance: immunoselection and immunosubversion , 2006, Nature Reviews Immunology.

[27]  Eric O Long.  Tumor cell recognition by natural killer cells. , 2002, Seminars in cancer biology.

[28]  P. Schlag,et al.  Prognostic significance of activated CD8(+) T cell infiltrations within esophageal carcinomas. , 2001, Cancer research.