Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): a potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery.
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J. Macor | R. Schartman | G. Thalody | G. Dubowchik | G. Cantor | Cen Xu | S. Pin | Laura J. Signor | C. Davis | N. Mathias | S. Mercer | R. Denton | Paul A Moench | V. Whiterock | Deborah Keavy | Charles M. Conway | P. V. Chaturvedula | R. Macci | Sokhom S. Pin