Early molecular events during in vitro chondrogenesis

[1]  E. Hunziker Mechanism of longitudinal bone growth and its regulation by growth plate chondrocytes , 1994, Microscopy research and technique.

[2]  D. Zinyk,et al.  Hif-1α regulates differentiation of limb bud mesenchyme and joint development , 2007, The Journal of cell biology.

[3]  W. Richter,et al.  Different culture media affect growth characteristics, surface marker distribution and chondrogenic differentiation of human bone marrow-derived mesenchymal stromal cells , 2013, BMC Musculoskeletal Disorders.

[4]  R. Boot-Handford,et al.  Lineage tracing using matrilin-1 gene expression reveals that articular chondrocytes exist as the joint interzone forms. , 2007, Developmental biology.

[5]  Qian Chen,et al.  MiR‐365: a mechanosensitive microRNA stimulates chondrocyte differentiation through targeting histone deacetylase 4 , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[6]  C. L. Murphy,et al.  Type II Collagen Expression Is Regulated by Tissue-specific miR-675 in Human Articular Chondrocytes* , 2010, The Journal of Biological Chemistry.

[7]  R. Boot-Handford,et al.  The expression and function of microRNAs in chondrogenesis and osteoarthritis. , 2012, Arthritis and rheumatism.

[8]  I. Sekiya,et al.  Methylation status of CpG islands in the promoter regions of signature genes during chondrogenesis of human synovium-derived mesenchymal stem cells. , 2009, Arthritis and rheumatism.

[9]  Masahiro Iwamoto,et al.  A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis. , 2008, Developmental biology.

[10]  S. Perez,et al.  Cell Culture Medium Composition and Translational Adult Bone Marrow‐Derived Stem Cell Research , 2006, Stem cells.

[11]  A. V. van Wijnen,et al.  FGFR1 Signaling Stimulates Proliferation of Human Mesenchymal Stem Cells by Inhibiting the Cyclin‐Dependent Kinase Inhibitors p21Waf1 and p27Kip1 , 2013, Stem cells.

[12]  Yi Luan,et al.  miR-199a*, a Bone Morphogenic Protein 2-responsive MicroRNA, Regulates Chondrogenesis via Direct Targeting to Smad1* , 2009, Journal of Biological Chemistry.

[13]  K. Bieback Platelet Lysate as Replacement for Fetal Bovine Serum in Mesenchymal Stromal Cell Cultures , 2013, Transfusion Medicine and Hemotherapy.

[14]  B. Hall,et al.  Divide, accumulate, differentiate: cell condensation in skeletal development revisited. , 2004, The International journal of developmental biology.

[15]  U. A. Ørom,et al.  MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation. , 2008, Molecular cell.

[16]  E. Schipani,et al.  Fetal Growth Plate , 2007, Annals of the New York Academy of Sciences.

[17]  A. Dopazo,et al.  miR-335 orchestrates cell proliferation, migration and differentiation in human mesenchymal stem cells , 2011, Cell Death and Differentiation.

[18]  Yukio Nakamura,et al.  Chondrocyte-Specific MicroRNA-140 Regulates Endochondral Bone Development and Targets Dnpep To Modulate Bone Morphogenetic Protein Signaling , 2011, Molecular and Cellular Biology.

[19]  N. Zhong,et al.  MicroRNAs of rat articular cartilage at different developmental stages identified by Solexa sequencing. , 2011, Osteoarthritis and cartilage.

[20]  K. Kuettner,et al.  Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and Is a multifunctional proteoglycan with potential growth-promoting, cytoprotective, and lubricating properties in cartilage metabolism. , 1999, Biochemical and biophysical research communications.

[21]  Xianzhe Liu,et al.  MicroRNA-21 controls the development of osteoarthritis by targeting GDF-5 in chondrocytes , 2014, Experimental & Molecular Medicine.

[22]  A. Monsoro-Burq,et al.  The role of bone morphogenetic proteins in vertebral development. , 1996, Development.

[23]  E. Hornstein,et al.  miRNAs control tracheal chondrocyte differentiation. , 2011, Developmental biology.

[24]  P. Robinson,et al.  miR-181a promotes osteoblastic differentiation through repression of TGF-β signaling molecules. , 2013, The international journal of biochemistry & cell biology.

[25]  Konstantinos N. Malizos,et al.  Integrative MicroRNA and Proteomic Approaches Identify Novel Osteoarthritis Genes and Their Collaborative Metabolic and Inflammatory Networks , 2008, PloS one.

[26]  S. Vasudevan Posttranscriptional Upregulation by MicroRNAs , 2012, Wiley interdisciplinary reviews. RNA.

[27]  R. Place,et al.  MicroRNA-373 induces expression of genes with complementary promoter sequences , 2008, Proceedings of the National Academy of Sciences.

[28]  Lin He,et al.  MicroRNAs: small RNAs with a big role in gene regulation , 2004, Nature reviews genetics.

[29]  J. Steadman,et al.  Treatment of articular cartilage defects in athletes: an analysis of functional outcome and lesion appearance. , 1998, Orthopedics.

[30]  R. Gambari,et al.  Pro-Chondrogenic Effect of miR-221 and Slug Depletion in Human MSCs , 2014, Stem Cell Reviews and Reports.

[31]  Yvonne Tay,et al.  MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation , 2008, Nature.

[32]  V. Ambros,et al.  The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 , 1993, Cell.

[33]  A. Lavrentieva,et al.  Potential for osteogenic and chondrogenic differentiation of MSC. , 2013, Advances in biochemical engineering/biotechnology.

[34]  E. Koyama,et al.  Genesis and morphogenesis of limb synovial joints and articular cartilage. , 2014, Matrix biology : journal of the International Society for Matrix Biology.

[35]  M. Pittenger,et al.  Multilineage potential of adult human mesenchymal stem cells. , 1999, Science.

[36]  S. Kauppinen,et al.  Experimental identification of microRNA-140 targets by silencing and overexpressing miR-140. , 2008, RNA.

[37]  H. Horvitz,et al.  MicroRNA Expression in Zebrafish Embryonic Development , 2005, Science.

[38]  A. Säämänen,et al.  MicroRNAs Regulate Osteogenesis and Chondrogenesis of Mouse Bone Marrow Stromal Cells , 2008, Gene regulation and systems biology.

[39]  T. Karlsen,et al.  Similar Properties of Chondrocytes from Osteoarthritis Joints and Mesenchymal Stem Cells from Healthy Donors for Tissue Engineering of Articular Cartilage , 2013, PloS one.

[40]  Mélanie Gadelorge,et al.  Production of mesenchymal stromal/stem cells according to good manufacturing practices: a review , 2013, Stem Cell Research & Therapy.

[41]  Andrew M. Handorf,et al.  Fibroblast Growth Factor-2 Primes Human Mesenchymal Stem Cells for Enhanced Chondrogenesis , 2011, PloS one.

[42]  A. Mikos,et al.  Enhancing chondrogenic phenotype for cartilage tissue engineering: monoculture and coculture of articular chondrocytes and mesenchymal stem cells. , 2014, Tissue engineering. Part B, Reviews.

[43]  R. Tuan,et al.  Cellular interactions and signaling in cartilage development. , 2000, Osteoarthritis and cartilage.

[44]  F. Reinholt,et al.  Chondrogenesis in a hyaluronic acid scaffold: comparison between chondrocytes and MSC from bone marrow and adipose tissue , 2010, Knee Surgery, Sports Traumatology, Arthroscopy.

[45]  I. Sekiya,et al.  Comparison of effect of BMP-2, -4, and -6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma , 2005, Cell and Tissue Research.

[46]  J. W. Lee,et al.  microRNA-495 inhibits chondrogenic differentiation in human mesenchymal stem cells by targeting Sox9. , 2014, Stem cells and development.

[47]  V. Goldberg,et al.  Fibroblast growth factor-2 enhances proliferation and delays loss of chondrogenic potential in human adult bone-marrow-derived mesenchymal stem cells. , 2010, Tissue engineering. Part A.

[48]  J. Lachuer,et al.  Overexpression of Transcription Factor Sp1 Leads to Gene Expression Perturbations and Cell Cycle Inhibition , 2009, PloS one.

[49]  D. Strunk,et al.  Human Alternatives to Fetal Bovine Serum for the Expansion of Mesenchymal Stromal Cells from Bone Marrow , 2009, Stem cells.

[50]  N Holder,et al.  An experimental investigation into the early development of the chick elbow joint. , 1977, Journal of embryology and experimental morphology.

[51]  Kenneth Dixon,et al.  Reduced chondrogenic and adipogenic activity of mesenchymal stem cells from patients with advanced osteoarthritis. , 2002, Arthritis and rheumatism.

[52]  S. Kauppinen,et al.  mRNA expression profiling reveals conserved and non-conserved miR-140 targets , 2011, RNA biology.

[53]  D. Saris,et al.  Overexpression of hsa-miR-148a promotes cartilage production and inhibits cartilage degradation by osteoarthritic chondrocytes. , 2014, Osteoarthritis and cartilage.

[54]  M. Ratajczak,et al.  Migration of Bone Marrow and Cord Blood Mesenchymal Stem Cells In Vitro Is Regulated by Stromal‐Derived Factor‐1‐CXCR4 and Hepatocyte Growth Factor‐c‐met Axes and Involves Matrix Metalloproteinases , 2006, Stem cells.

[55]  S. Mundlos,et al.  Regulation of chondrocyte differentiation by Cbfa1 , 1999, Mechanisms of Development.

[56]  G. Hutvagner,et al.  A microRNA in a Multiple-Turnover RNAi Enzyme Complex , 2002, Science.

[57]  J. Abbott,et al.  THE LOSS OF PHENOTYPIC TRAITS BY DIFFERENTIATED CELLS IN VITRO, I. DEDIFFERENTIATION OF CARTILAGE CELLS. , 1960, Proceedings of the National Academy of Sciences of the United States of America.

[58]  Sinnakaruppan Mathavan,et al.  Prepatterning of developmental gene expression by modified histones before zygotic genome activation. , 2011, Developmental cell.

[59]  Peter G Farlie,et al.  Global comparative transcriptome analysis of cartilage formation in vivo , 2009, BMC Developmental Biology.

[60]  A. Reddi,et al.  Profiling microRNA expression in bovine articular cartilage and implications for mechanotransduction. , 2009, Arthritis and rheumatism.

[61]  J. Postlethwait,et al.  MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis , 2008, Nature Genetics.

[62]  F. Luyten,et al.  Donor site morbidity after articular cartilage repair procedures: a review. , 2010, Acta orthopaedica Belgica.

[63]  Darwin J. Prockop,et al.  In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[64]  Chen-Chung Lin,et al.  A KLF4–miRNA-206 Autoregulatory Feedback Loop Can Promote or Inhibit Protein Translation Depending upon Cell Context , 2011, Molecular and Cellular Biology.

[65]  D. Ying,et al.  MicroRNA-145 Regulates Chondrogenic Differentiation of Mesenchymal Stem Cells by Targeting Sox9 , 2011, PloS one.

[66]  J. Cinatl,et al.  Prions and Orthopedic Surgery , 2003, Infection.

[67]  Seyed Hassan Paylakhi,et al.  A microRNA signature associated with chondrogenic lineage commitment , 2012, Journal of Genetics.

[68]  C. Burge,et al.  Most mammalian mRNAs are conserved targets of microRNAs. , 2008, Genome research.

[69]  V. Patel,et al.  MicroRNAs and fibrosis , 2012, Current opinion in nephrology and hypertension.

[70]  D. Cacchiarelli,et al.  Brief Report: Importance of SOX8 for In Vitro Chondrogenic Differentiation of Human Mesenchymal Stromal Cells , 2014, Stem cells.

[71]  J. Song,et al.  MicroRNA-221 Regulates Chondrogenic Differentiation through Promoting Proteosomal Degradation of Slug by Targeting Mdm2* , 2010, The Journal of Biological Chemistry.

[72]  L. Maeng,et al.  Upregulation of miR-23b Enhances the Autologous Therapeutic Potential for Degenerative Arthritis by Targeting PRKACB in Synovial Fluid-Derived Mesenchymal Stem Cells from Patients , 2014, Molecules and cells.

[73]  Shu-Ching Hsu,et al.  Internalized antigens must be removed to prepare hypoimmunogenic mesenchymal stem cells for cell and gene therapy. , 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

[74]  A I Caplan,et al.  In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. , 1998, Experimental cell research.

[75]  D. Ying,et al.  The microRNA expression profiles of mouse mesenchymal stem cell during chondrogenic differentiation. , 2011, BMB reports.

[76]  F. Barry,et al.  Mesenchymal stem cells in joint disease and repair , 2013, Nature Reviews Rheumatology.

[77]  X. Duan,et al.  Expression of microRNAs during chondrogenesis of human adipose-derived stem cells. , 2012, Osteoarthritis and cartilage.

[78]  K. Lyons,et al.  Human Developmental Chondrogenesis as a Basis for Engineering Chondrocytes from Pluripotent Stem Cells , 2013, Stem cell reports.

[79]  Jean-Marie Denoix,et al.  Cartilage tissue engineering: molecular control of chondrocyte differentiation for proper cartilage matrix reconstruction. , 2014, Biochimica et biophysica acta.

[80]  M. Ochi,et al.  Intra-articular injection of synthetic microRNA-210 accelerates avascular meniscal healing in rat medial meniscal injured model , 2014, Arthritis Research & Therapy.

[81]  Gerard A. Ateshian,et al.  Large, stratified, and mechanically functional human cartilage grown in vitro by mesenchymal condensation , 2014, Proceedings of the National Academy of Sciences.

[82]  R. Shiekhattar,et al.  MicroRNA biogenesis: isolation and characterization of the microprocessor complex. , 2006, Methods in molecular biology.

[83]  Kozo Nakamura,et al.  The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage. , 2004, Arthritis and rheumatism.

[84]  G. Zardo,et al.  Transcriptional targeting by microRNA-Polycomb complexes , 2012, Cell cycle.

[85]  S. Takada,et al.  L-Sox5 and Sox6 Proteins Enhance Chondrogenic miR-140 MicroRNA Expression by Strengthening Dimeric Sox9 Activity* , 2012, The Journal of Biological Chemistry.

[86]  Lars Engebretsen,et al.  A randomized trial comparing autologous chondrocyte implantation with microfracture. Findings at five years. , 2007, The Journal of bone and joint surgery. American volume.

[87]  C. Ohlsson,et al.  Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. , 1994, The New England journal of medicine.

[88]  J. Post,et al.  Metabolic programming of mesenchymal stromal cells by oxygen tension directs chondrogenic cell fate , 2014, Proceedings of the National Academy of Sciences.

[89]  B. Lim,et al.  Identification of Common Pathways Mediating Differentiation of Bone Marrow‐ and Adipose Tissue‐Derived Human Mesenchymal Stem Cells into Three Mesenchymal Lineages , 2007, Stem cells.

[90]  Vincent Moulton,et al.  Analyzing mRNA expression identifies Smad3 as a microRNA-140 target regulated only at protein level. , 2010, RNA.

[91]  Jane Qiu,et al.  Epigenetics: Unfinished symphony , 2006, Nature.

[92]  R. Walker,et al.  Development of antibodies to fetal calf serum with arthus-like reactions in human immunodeficiency virus-infected patients given syngeneic lymphocyte infusions. , 1997, Blood.

[93]  P. Collas,et al.  Closing the (nuclear) envelope on the genome: How nuclear lamins interact with promoters and modulate gene expression , 2014, BioEssays : news and reviews in molecular, cellular and developmental biology.

[94]  Elizabeth G Loboa,et al.  Cytoskeletal and focal adhesion influences on mesenchymal stem cell shape, mechanical properties, and differentiation down osteogenic, adipogenic, and chondrogenic pathways. , 2012, Tissue engineering. Part B, Reviews.

[95]  C. L. Murphy,et al.  Regulation of Human Chondrocyte Function through Direct Inhibition of Cartilage Master Regulator SOX9 by MicroRNA-145 (miRNA-145)* , 2011, The Journal of Biological Chemistry.

[96]  G. Lisignoli,et al.  CXCL12 (SDF‐1) and CXCL13 (BCA‐1) chemokines significantly induce proliferation and collagen type I expression in osteoblasts from osteoarthritis patients , 2006, Journal of cellular physiology.

[97]  T. Dalmay,et al.  The cartilage specific microRNA‐140 targets histone deacetylase 4 in mouse cells , 2006, FEBS letters.

[98]  T. Yamashiro,et al.  Novel role of miR‐181a in cartilage metabolism , 2013, Journal of cellular biochemistry.

[99]  I. Weissman,et al.  Epigenetic and in vivo comparison of diverse MSC sources reveals an endochondral signature for human hematopoietic niche formation. , 2015, Blood.

[100]  Takashi Nakamura,et al.  Stromal Cell-Derived Factor 1 Regulates the Actin Organization of Chondrocytes and Chondrocyte Hypertrophy , 2012, PloS one.

[101]  J. Stenvang,et al.  MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo , 2011, Proceedings of the National Academy of Sciences.

[102]  T. Karlsen,et al.  Human primary articular chondrocytes, chondroblasts-like cells, and dedifferentiated chondrocytes: differences in gene, microRNA, and protein expression and phenotype. , 2011, Tissue engineering. Part C, Methods.

[103]  D. Bartel MicroRNAs Genomics, Biogenesis, Mechanism, and Function , 2004, Cell.

[104]  J. Brinchmann,et al.  Chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells in self-gelling alginate discs reveals novel chondrogenic signature gene clusters. , 2011, Tissue engineering. Part A.

[105]  Shengying Qin,et al.  MiR‐140 is co‐expressed with Wwp2‐C transcript and activated by Sox9 to target Sp1 in maintaining the chondrocyte proliferation , 2011, FEBS letters.

[106]  T. Yamashiro,et al.  Identification of miR-1 as a micro RNA that supports late-stage differentiation of growth cartilage cells. , 2010, Biochemical and biophysical research communications.

[107]  Y. Sakaguchi,et al.  Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source. , 2005, Arthritis and rheumatism.

[108]  W. Richter,et al.  Correlation of COL10A1 induction during chondrogenesis of mesenchymal stem cells with demethylation of two CpG sites in the COL10A1 promoter. , 2008, Arthritis and rheumatism.

[109]  T. Mikkelsen,et al.  Analysis of the Effects of Five Factors Relevant to In Vitro Chondrogenesis of Human Mesenchymal Stem Cells Using Factorial Design and High Throughput mRNA-Profiling , 2014, PloS one.

[110]  A. McMahon,et al.  Dicer-dependent pathways regulate chondrocyte proliferation and differentiation , 2008, Proceedings of the National Academy of Sciences.

[111]  M. Strioga,et al.  Same or not the same? Comparison of adipose tissue-derived versus bone marrow-derived mesenchymal stem and stromal cells. , 2012, Stem cells and development.

[112]  Li-Wei Chang,et al.  Differentially Expressed MicroRNAs in Chondrocytes from Distinct Regions of Developing Human Cartilage , 2013, PloS one.

[113]  T. Mikkelsen,et al.  Genome-wide map of quantified epigenetic changes during in vitro chondrogenic differentiation of primary human mesenchymal stem cells , 2013, BMC Genomics.

[114]  C. Sen,et al.  miR‐210: The Master Hypoxamir , 2012, Microcirculation.

[115]  T. Mikkelsen,et al.  microRNA-140 targets RALA and regulates chondrogenic differentiation of human mesenchymal stem cells by translational enhancement of SOX9 and ACAN. , 2014, Stem cells and development.

[116]  T. Hardingham,et al.  Notch Signaling Through Jagged‐1 Is Necessary to Initiate Chondrogenesis in Human Bone Marrow Stromal Cells but Must Be Switched off to Complete Chondrogenesis , 2008, Stem cells.

[117]  Hong Zhou,et al.  MicroRNA hsa-miR-138 inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells through adenovirus EID-1. , 2011, Stem cells and development.

[118]  M. Goldring,et al.  The control of chondrogenesis , 2006, Journal of cellular biochemistry.

[119]  N. Rajewsky,et al.  Widespread changes in protein synthesis induced by microRNAs , 2008, Nature.

[120]  Adele Hill,et al.  Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators , 2008, Current opinion in cell biology.

[121]  J. Postlethwait,et al.  Sox9 Is Upstream of MicroRNA-140 in Cartilage , 2011, Applied Biochemistry and Biotechnology.

[122]  R. Harland,et al.  The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4 , 1996, Cell.

[123]  Xue-cheng Sun,et al.  Association of CXCL12 Levels in Synovial Fluid With the Radiographic Severity of Knee Osteoarthritis , 2012, Journal of Investigative Medicine.

[124]  A. Boskey,et al.  Notch Signaling in Osteocytes Differentially Regulates Cancellous and Cortical Bone Remodeling* , 2013, The Journal of Biological Chemistry.

[125]  R. Russell,et al.  Principles of MicroRNA–Target Recognition , 2005, PLoS biology.

[126]  S. Takada,et al.  MicroRNA-140 plays dual roles in both cartilage development and homeostasis. , 2010, Genes & development.

[127]  Zachary D. Smith,et al.  DNA methylation: roles in mammalian development , 2013, Nature Reviews Genetics.

[128]  Katrine Frønsdal,et al.  In Vitro Expansion of Human Mesenchymal Stem Cells: Choice of Serum Is a Determinant of Cell Proliferation, Differentiation, Gene Expression, and Transcriptome Stability , 2005, Stem cells.

[129]  L. Wolpert,et al.  Overexpression of BMP-2 and BMP-4 alters the size and shape of developing skeletal elements in the chick limb , 1996, Mechanisms of Development.

[130]  P. Sikorski,et al.  Biochemical and Structural Characterization of Neocartilage Formed by Mesenchymal Stem Cells in Alginate Hydrogels , 2014, PloS one.