Metabolic changes during carcinogenesis: potential impact on invasiveness.

[1]  Peter Bartenstein,et al.  Overexpression of Glut‐1 and increased glucose metabolism in tumors are associated with a poor prognosis in patients with oral squamous cell carcinoma , 2003, Cancer.

[2]  P. Vaupel,et al.  Glucose uptake, lactate release, ketone body turnover, metabolic micromilieu, and pH distributions in human breast cancer xenografts in nude rats. , 1988, Cancer research.

[3]  E. Racker.  History of the Pasteur effect and its pathobiology , 1974, Molecular and Cellular Biochemistry.

[4]  P. Maini,et al.  The role of acidity in solid tumour growth and invasion. , 2005, Journal of theoretical biology.

[5]  S. Gambhir.  Molecular imaging of cancer with positron emission tomography , 2002, Nature Reviews Cancer.

[6]  M G Nichols,et al.  Oxygen diffusion and reaction kinetics in the photodynamic therapy of multicell tumour spheroids. , 1994, Physics in medicine and biology.

[7]  K. Groebe,et al.  Glucose diffusion coefficients determined from concentration profiles in EMT6 tumor spheroids incubated in radioactively labeled L-glucose. , 1994, Advances in experimental medicine and biology.

[8]  E. T. Gawlinski,et al.  A reaction-diffusion model of cancer invasion. , 1996, Cancer research.

[9]  N. Komarova.  Mathematical modeling of tumorigenesis: mission possible , 2005, Current opinion in oncology.

[10]  A. Anderson,et al.  A hybrid mathematical model of solid tumour invasion: the importance of cell adhesion. , 2005, Mathematical medicine and biology : a journal of the IMA.

[11]  E. T. Gawlinski,et al.  A cellular automaton model of early tumor growth and invasion. , 2001, Journal of theoretical biology.

[12]  R. Gillies,et al.  Why do cancers have high aerobic glycolysis? , 2004, Nature Reviews Cancer.

[13]  B. Vogelstein,et al.  A genetic model for colorectal tumorigenesis , 1990, Cell.

[14]  J. Shirlaw.  THE METABOLISM OF TUMOURS , 1931 .

[15]  P. Maini,et al.  A cellular automaton model for tumour growth in inhomogeneous environment. , 2003, Journal of theoretical biology.

[16]  E. T. Gawlinski,et al.  The possible role of postoperative azotemia in enhanced survival of patients with metastatic renal cancer after cytoreductive nephrectomy. , 2002, Cancer research.

[17]  S. Schreiber,et al.  Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[18]  L. H. Gray,et al.  The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy , 1955, British Journal of Cancer.

[19]  Rakesh K. Jain,et al.  Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation , 1997, Nature Medicine.

[20]  G. di Chiro,et al.  Glucose utilization by intracranial meningiomas as an index of tumor aggressivity and probability of recurrence: a PET study. , 1987, Radiology.

[21]  René Bernards,et al.  A progression puzzle. , 2002, Nature.

[22]  M. Melicow.  The three steps to cancer: a new concept of cancerigenesis. , 1982, Journal of theoretical biology.

[23]  S. V. Sotirchos,et al.  Variations in tumor cell growth rates and metabolism with oxygen concentration, glucose concentration, and extracellular pH , 1992, Journal of cellular physiology.

[24]  Michael E Phelps,et al.  Positron emission tomography scanning: current and future applications. , 2002, Annual review of medicine.

[25]  E. T. Gawlinski,et al.  A Cellular Automaton Model of Early Tumor Growth and Invasion: The Effects of Native Tissue Vascularity and Increased Anaerobic Tumor Metabolism , 2001 .

[26]  A Krogh,et al.  The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue , 1919, The Journal of physiology.

[27]  M. Eigen.  Selforganization of matter and the evolution of biological macromolecules , 1971, Naturwissenschaften.

[28]  Bonnie F. Sloane,et al.  Pericellular pH affects distribution and secretion of cathepsin B in malignant cells. , 1994, Cancer research.

[29]  Robert J Gillies,et al.  Contributions of cell metabolism and H+ diffusion to the acidic pH of tumors. , 2003, Neoplasia.

[30]  E. Boyland.  Metabolism of Tumours , 1940, Nature.

[31]  E. Hill.  Journal of Theoretical Biology , 1961, Nature.

[32]  Peter Schuster.  How do RNA molecules and viruses explore their worlds , 1999 .

[33]  W. Godwin.  Article in Press , 2000 .

[34]  P. Maini,et al.  Mathematical oncology: Cancer summed up , 2003, Nature.

[35]  E. T. Gawlinski,et al.  The glycolytic phenotype in carcinogenesis and tumor invasion: insights through mathematical models. , 2003, Cancer research.

[36]  J F Gross,et al.  Determination of local oxygen consumption rates in tumors. , 1994, Cancer research.

[37]  W. Sly,et al.  Expression of the hypoxia-inducible and tumor-associated carbonic anhydrases in ductal carcinoma in situ of the breast. , 2001, The American journal of pathology.