Arginine-Based Inhibitors of Nitric Oxide Synthase: Therapeutic Potential and Challenges
暂无分享,去创建一个
Antonín Lojek | Lukáš Kubala | Jan Víteček | A. Lojek | G. Valacchi | J. Víteček | L. Kubala | Giuseppe Valacchi
[1] J. Tainer,et al. Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase , 2008, Nature chemical biology.
[2] J. Olesen,et al. A dose–response study of nitric oxide synthase inhibition in different vascular beds in man , 2003, European Journal of Clinical Pharmacology.
[3] D. Yang,et al. Estrogen-induced uterine vasodilatation is antagonized by L-nitroarginine methyl ester, an inhibitor of nitric oxide synthesis. , 1992, American journal of obstetrics and gynecology.
[4] D. Kellogg,et al. Roles of nitric oxide synthase isoforms in cutaneous vasodilation induced by local warming of the skin and whole body heat stress in humans. , 2009, Journal of applied physiology.
[5] E. Jaffe,et al. Macrophage and endothelial cell nitric oxide synthesis: cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine. , 1990, Biochemical and biophysical research communications.
[6] C. F. Wilkinson,et al. Steric factors in the inhibitory interaction of imidazoles with microsomal enzymes. , 1977, Biochemical pharmacology.
[7] S. Snyder,et al. Nitric oxide: a neural messenger. , 1995, Annual review of cell and developmental biology.
[8] C. Andressen,et al. NOS-II is involved in early differentiation of murine cortical, retinal and ES cell-derived neurons—an immunocytochemical and functional approach , 2002, International Journal of Developmental Neuroscience.
[9] J. Vincent,et al. An open-label dose escalation study of the nitric oxide synthase inhibitor, NG-methyl-L-arginine hydrochloride (546C88), in patients with septic shock , 1999 .
[10] J. Bakker,et al. Administration of the nitric oxide synthase inhibitor NG-methyl-l-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: Results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144- , 2004, Critical care medicine.
[11] C. Szabó,et al. BENEFICIAL VERSUS DETRIMENTAL EFFECTS OF NITRIC OXIDE SYNTHASE INHIBITORS IN CIRCULATORY SHOCK LESSONS LEARNED FROM EXPERIMENTAL AND CLINICAL STUDIES , 1997, Shock.
[12] J. Zweier,et al. Endogenous Methylarginines Regulate Neuronal Nitric-oxide Synthase and Prevent Excitotoxic Injury* , 2002, The Journal of Biological Chemistry.
[13] O. Griffith,et al. Design of isoform-selective inhibitors of nitric oxide synthase. , 1998, Current opinion in chemical biology.
[14] E. Block,et al. Inhibition of endothelial cell amino acid transport System y+ by arginine analogs that inhibit nitric oxide synthase. , 1997, Biochimica et biophysica acta.
[15] K. Kikuchi,et al. Dipeptides containing L-arginine analogs: new isozyme-selective inhibitors of nitric oxide synthase. , 1999, Biological & pharmaceutical bulletin.
[16] J. Olesen,et al. The effect of I.V. L-NG Methylarginine Hydrochloride (L-NMMA: 546C88) on Basal and Acetazolamide (Diamox®) induced Changes of Blood Velocity in Cerebral Arteries and Regional Cerebral Blood flow in Man , 2005, Cephalalgia : an international journal of headache.
[17] L. Ignarro,et al. NG-amino-L-arginine: a new potent antagonist of L-arginine-mediated endothelium-dependent relaxation. , 1990, Biochemical and biophysical research communications.
[18] E. Cartwright,et al. Neuronal Nitric Oxide Synthase Signaling in the Heart Is Regulated by the Sarcolemmal Calcium Pump 4b , 2007, Circulation.
[19] J. Balligand,et al. Control of cardiac muscle cell function by an endogenous nitric oxide signaling system. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[20] S Moncada,et al. Role of endothelium-derived nitric oxide in the regulation of blood pressure. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[21] J. Duffield,et al. Activated Macrophages Direct Apoptosis and Suppress Mitosis of Mesangial Cells1 , 2000, The Journal of Immunology.
[22] M. Currie,et al. Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase. , 1995, European journal of pharmacology.
[23] Haitao Ji,et al. Conformationally restricted dipeptide amides as potent and selective neuronal nitric oxide synthase inhibitors. , 2006, Journal of medicinal chemistry.
[24] P. Martásek,et al. Design, synthesis, and biological testing of potential heme-coordinating nitric oxide synthase inhibitors. , 2006, Bioorganic & medicinal chemistry.
[25] H. Bruining,et al. Distribution and metabolism of N G-nitro-l-arginine methyl ester in patients with septic shock , 1998, European Journal of Clinical Pharmacology.
[26] T. Poulos,et al. Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping. , 2009, Journal of medicinal chemistry.
[27] T. Poulos,et al. Computer modeling of selective regions in the active site of nitric oxide synthases: implication for the design of isoform-selective inhibitors. , 2003, Journal of medicinal chemistry.
[28] S. Moncada,et al. Effects of a nitric oxide synthase inhibitor in humans with septic shock. , 1994, Cardiovascular research.
[29] A. Gibson,et al. l‐NG‐nitro arginine (l‐NOARG), a novel, l‐arginine‐reversible inhibitor of endothelium‐dependent vasodilatation in vitro , 1990, British journal of pharmacology.
[30] S Amerini,et al. Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. , 1994, The Journal of clinical investigation.
[31] G. Burnstock,et al. Effects of nitric oxide synthase inhibitors, l‐NG‐nitroarginine and l‐NG‐nitroarginine methyl ester, on responses to vasodilators of the guinea‐pig coronary vasculature , 1992, British journal of pharmacology.
[32] M. Marletta,et al. NG-allyl- and NG-cyclopropyl-L-arginine: two novel inhibitors of macrophage nitric oxide synthase. , 1992, Journal of medicinal chemistry.
[33] M. Capogrossi,et al. Homeodomain Interacting Protein Kinase 2 Activation Compromises Endothelial Cell Response to Laminar Flow: Protective Role of p21waf1,cip1,sdi1 , 2009, PloS one.
[34] Sucharita Das,et al. Loss of retinal ganglion cells following retinal ischemia: the role of inducible nitric oxide synthase. , 2002, Experimental eye research.
[35] M. Salter,et al. Potent and selective inhibition of human nitric oxide synthases. Selective inhibition of neuronal nitric oxide synthase by S-methyl-L-thiocitrulline and S-ethyl-L-thiocitrulline. , 1994, The Journal of biological chemistry.
[36] M. Currie,et al. 2-Iminopyrrolidines as potent and selective inhibitors of human inducible nitric oxide synthase. , 1998, Journal of medicinal chemistry.
[37] J. Bakker,et al. Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: Effect on survival in patients with septic shock* , 2004, Critical care medicine.
[38] V. Steele,et al. Is inducible nitric oxide synthase a target for chemoprevention? , 2003, Molecular cancer therapeutics.
[39] D. Dexter,et al. Neuroprotection by the selective iNOS inhibitor GW274150 in a model of Parkinson disease. , 2011, Free radical biology & medicine.
[40] A. Tinker,et al. Selective inhibitors of inducible nitric oxide synthase: potential agents for the treatment of inflammatory diseases? , 2006, Current topics in medicinal chemistry.
[41] O. Griffith,et al. Synthesis of L-thiocitrulline, L-homothiocitrulline, and S-methyl-L-thiocitrulline: a new class of potent nitric oxide synthase inhibitors. , 1994, Journal of medicinal chemistry.
[42] S. Maddaford,et al. Chapter 2 Advancements in the Development of Nitric Oxide Synthase Inhibitors , 2009 .
[43] A. Sobel,et al. The Journal of Biological Chemistry. , 2009, Nutrition reviews.
[44] H. Matter,et al. Inhibition of neuronal nitric oxide synthase by 4-amino pteridine derivatives: structure-activity relationship of antagonists of (6R)-5,6,7,8-tetrahydrobiopterin cofactor. , 1999, Journal of medicinal chemistry.
[45] M. Currie,et al. Inhibitors of human nitric oxide synthase isoforms with the carbamidine moiety as a common structural element. , 1996, Bioorganic & medicinal chemistry.
[46] H. Seller,et al. Neuronal nitric oxide reduces sympathetic excitability by modulation of central glutamate effects in pigs. , 1997, Circulation research.
[47] Richard Graham Knowles,et al. GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo , 2005, British journal of pharmacology.
[48] M. Salter,et al. N-Phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: structure-activity studies and demonstration of in vivo activity. , 1998, Journal of medicinal chemistry.
[49] R. Butterworth,et al. Kinetics, Pharmacology, and Autoradiographic Distribution of l‐[3H]Nitroarginine Binding Sites in Rat Cerebellum , 1996, Journal of neurochemistry.
[50] I. Adcock,et al. Role of nitric oxide in allergic inflammation and bronchial hyperresponsiveness. , 2002, European journal of pharmacology.
[51] Dragos Horvath,et al. Fragment-based drug design: computational & experimental state of the art. , 2011, Combinatorial chemistry & high throughput screening.
[52] J. Mudgett,et al. Identification of nitric oxide synthase as a protective locus against tuberculosis. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[53] B. Mayer,et al. Inhibition of nitric oxide synthesis by NG‐nitro‐L‐arginine methyl ester (L‐NAME): requirement for bioactivation to the free acid, NG‐nitro‐L‐arginine , 1996, British journal of pharmacology.
[54] Hans Matter,et al. Structural requirements for inhibition of the neuronal nitric oxide synthase (NOS-I): 3D-QSAR analysis of 4-oxo- and 4-amino-pteridine-based inhibitors. , 2002, Journal of medicinal chemistry.
[55] Antje Chang,et al. BRENDA, the enzyme information system in 2011 , 2010, Nucleic Acids Res..
[56] P. Tripathi. Nitric oxide and immune response. , 2007, Indian journal of biochemistry & biophysics.
[57] C. Lowenstein,et al. Nitric Oxide: A Physiologic Messenger , 1994, Annals of Internal Medicine.
[58] O. Griffith,et al. Synthesis of L‐Thiocitrulline (IVa), L‐Homothiocitrulline (IVb) and S‐ Methyl‐L‐thiocitrulline (VI): A New Class of Potent Nitric Oxide Synthase Inhibitors. , 1994 .
[59] J. Umans,et al. Nitric oxide in the regulation of blood flow and arterial pressure. , 1995, Annual review of physiology.
[60] P. Klatt,et al. Inhibitors of brain nitric oxide synthase. Binding kinetics, metabolism, and enzyme inactivation. , 1994, The Journal of biological chemistry.
[61] J. Adams,et al. Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis. , 1990, Biochemical and biophysical research communications.
[62] T. Dawson,et al. Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[63] D. Webb,et al. Inhibition of nitric oxide synthesis increases blood pressure in healthy humans , 1993, Journal of hypertension.
[64] E. Garvey,et al. Potent and Selective Inhibition of Human Nitric Oxide Synthases , 1994 .
[65] M. Currie,et al. Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase. , 1998, Arthritis and rheumatism.
[66] T. Poulos,et al. Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy , 2009, Annals of neurology.
[67] N. Patel,et al. Beneficial effects of GW274150 treatment on the development of experimental colitis induced by dinitrobenzene sulfonic acid. , 2005, European journal of pharmacology.
[68] F. László,et al. Actions of isoform-selective and non-selective nitric oxide synthase inhibitors on endotoxin-induced vascular leakage in rat colon. , 1997, European journal of pharmacology.
[69] S. Clarke,et al. Protein arginine methylation in mammals: who, what, and why. , 2009, Molecular cell.
[70] Y. Hellsten,et al. Exercise‐induced hyperaemia and leg oxygen uptake are not altered during effective inhibition of nitric oxide synthase with NG‐nitro‐l‐arginine methyl ester in humans , 2001, The Journal of physiology.
[71] T. Maurer,et al. Nonlinear pharmacokinetics of L‐NG‐methyl‐arginine in rats: characterization by an improved HPLC assay , 1999, Biopharmaceutics & drug disposition.
[72] S. Moncada,et al. Identification of N‐iminoethyl‐l‐ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells , 1991, British journal of pharmacology.
[73] S. Moncada,et al. Production of nitric oxide and superoxide by activated macrophages and killing of Leishmania major , 1994, European journal of immunology.
[74] J. Ellrich,et al. Neuronal Nitric Oxide Synthase is Involved in the Induction of Nerve Growth Factor‐Induced Neck Muscle Nociception , 2011, Headache.
[75] J. Engel,et al. The neuronal selective nitric oxide synthase inhibitor, Nomega-propyl-L-arginine, blocks the effects of phencyclidine on prepulse inhibition and locomotor activity in mice. , 2004, European journal of pharmacology.
[76] K. Pahan,et al. Induction of Glial Fibrillary Acidic Protein Expression in Astrocytes by Nitric Oxide , 2006, The Journal of Neuroscience.
[77] J. Stamler,et al. Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans. , 1994, Circulation.
[78] R. Böger. The emerging role of asymmetric dimethylarginine as a novel cardiovascular risk factor. , 2003, Cardiovascular research.
[79] M. Marletta,et al. N(ω)-Propargyl-L-arginine and N(ω)-hydroxy-N(ω)-propargyl-L-arginine are inhibitors, but not activators, of neuronal and macrophage nitric oxide synthases , 1997 .
[80] H. Bruining,et al. Prolonged inhibition of nitric oxide synthesis in severe septic shock: a clinical study. , 1998, Critical care medicine.
[81] Y. Itzhak,et al. Long-term memory of visually cued fear conditioning: roles of the neuronal nitric oxide synthase gene and cyclic AMP response element-binding protein , 2011, Neuroscience.
[82] C. Zoccali,et al. Asymmetric dimethylarginine: a cardiovascular risk factor and a uremic toxin coming of age? , 2005, American journal of kidney diseases : the official journal of the National Kidney Foundation.
[83] Glen Andrews,et al. The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS). , 2011, Bioorganic & medicinal chemistry letters.
[84] A. Woodcock,et al. Selective inducible nitric oxide synthase inhibition has no effect on allergen challenge in asthma. , 2007, American journal of respiratory and critical care medicine.
[85] A. Kirkham,et al. Lack of efficacy of the selective iNOS inhibitor GW274150 in prophylaxis of migraine headache , 2010, Cephalalgia : an international journal of headache.
[86] E. Kidd,et al. Autoradiographic distribution of [3H]l-N G-Nitro-arginine binding in rat brain , 1995, Neuropharmacology.
[87] Jiwon Seo,et al. Selective L-nitroargininylaminopyrrolidine and L-nitroargininylaminopiperidine neuronal nitric oxide synthase inhibitors. , 2007, Bioorganic & medicinal chemistry.
[88] P. Klatt,et al. Characterization of endothelial cell amino acid transport systems involved in the actions of nitric oxide synthase inhibitors. , 1993, Molecular pharmacology.
[89] C. Dence,et al. Synthesis, in vivo evaluation and PET study of a carbon-11-labeled neuronal nitric oxide synthase (nNOS) inhibitor S-methyl-L-thiocitrulline. , 1997, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
[90] J. Olesen,et al. The Effect of Nitric Oxide Synthase Inhibition on Histamine Induced Headache and Arterial Dilatation in Migraineurs , 2003, Cephalalgia : an international journal of headache.
[91] C. Cooper,et al. Nitric oxide synthases: structure, function and inhibition. , 2001, The Biochemical journal.
[92] M. Currie,et al. Synthesis and biological characterization of L-N(6)-(1-iminoethyl)lysine 5-tetrazole-amide, a prodrug of a selective iNOS inhibitor. , 2002, Journal of medicinal chemistry.
[93] O. Griffith,et al. NG-methylarginine, an inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: does nitric oxide regulate blood pressure in vivo? , 1989, Biochemical and biophysical research communications.
[94] M. Currie,et al. L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. , 1994, Journal of Medicinal Chemistry.
[95] M. Marletta,et al. Selective inhibition of neuronal nitric oxide synthase by N omega-nitroarginine-and phenylalanine-containing dipeptides and dipeptide esters. , 1997, Journal of medicinal chemistry.
[96] T. Poulos,et al. Minimal pharmacophoric elements and fragment hopping, an approach directed at molecular diversity and isozyme selectivity. Design of selective neuronal nitric oxide synthase inhibitors. , 2008, Journal of the American Chemical Society.
[97] S. Moncada,et al. L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation. , 1988, Biochemical and biophysical research communications.
[98] Richard Graham Knowles,et al. GW274150, a novel and highly selective inhibitor of the inducible isoform of nitric oxide synthase (iNOS), shows analgesic effects in rat models of inflammatory and neuropathic pain , 2006, Pain.
[99] Richard Graham Knowles,et al. y+ LAT-1 mediates transport of the potent and selective iNOS inhibitor, GW274150, in control J774 macrophages , 2006, Amino Acids.
[100] F. Palm,et al. Cellular ADMA: regulation and action. , 2009, Pharmacological research.
[101] J. Sixma,et al. Nitric Oxide Functions as an Inhibitor of Platelet Adhesion Under Flow Conditions , 1992, Circulation.
[102] E. Garvey,et al. Selective inhibition of constitutive nitric oxide synthase by L-NG-nitroarginine. , 1993, Biochemistry.
[103] D. J. Wolff,et al. Cellular and enzymatic studies of N(omega)-propyl-l-arginine and S-ethyl-N-[4-(trifluoromethyl)phenyl]isothiourea as reversible, slowly dissociating inhibitors selective for the neuronal nitric oxide synthase isoform. , 2000, Archives of biochemistry and biophysics.
[104] S. Moncada,et al. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure , 1992, The Lancet.
[105] Y. Urano,et al. Selective inhibition of human inducible nitric oxide synthase by S‐alkyl‐L‐isothiocitrulline‐containing dipeptides , 2001, British journal of pharmacology.
[106] E. Chinje,et al. Heterocyclic analogues of L-citrulline as inhibitors of the isoforms of nitric oxide synthase (NOS) and identification of N(delta)-(4,5-dihydrothiazol-2-yl)ornithine as a potent inhibitor. , 1999, Bioorganic & medicinal chemistry.
[107] Ryosuke Ijuin,et al. Design, synthesis, and evaluation of new type of L-amino acids containing pyridine moiety as nitric oxide synthase inhibitor. , 2006, Bioorganic & medicinal chemistry.
[108] S H Snyder,et al. Nitric oxide in the nervous system. , 1995, Annual review of pharmacology and toxicology.
[109] P. Vallance,et al. Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock , 1991, The Lancet.
[110] M. Marletta,et al. Mechanism of inactivation of neuronal nitric oxide synthase by N(ω)-allyl-L-arginine , 1997 .
[111] S. Ekins,et al. In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling , 2007, British journal of pharmacology.
[112] M. Milton,et al. Disposition and pharmacokinetics of L-N6-(1-iminoethyl)lysine-5-tetrazole-amide, a selective iNOS inhibitor, in rats. , 2004, Journal of pharmaceutical sciences.
[113] J. Olesen,et al. Effect of inhibition of nitric oxide synthase on chronic tension-type headache: a randomised crossover trial , 1999, The Lancet.
[114] E. Mazzon,et al. Effects of GW274150, a novel and selective inhibitor of iNOS activity, in acute lung inflammation , 2004, British journal of pharmacology.
[115] G. Garcı́a-Cardeña,et al. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. , 1997, The Journal of clinical investigation.
[116] M. Singer,et al. Temporal variation in endotoxin‐induced vascular hyporeactivity in a rat mesenteric artery organ culture model , 2001, British journal of pharmacology.
[117] M. Beal,et al. N-iminoethyl-l-lysine improves memory and reduces amyloid pathology in a transgenic mouse model of amyloid deposition , 2010, Neurochemistry International.
[118] B. Masters,et al. L-thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases. , 1994, The Journal of biological chemistry.
[119] J. Vane,et al. On the substrate specificity of nitric oxide synthase , 1991, FEBS letters.
[120] A. Tinker,et al. 1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo. , 2003, Journal of medicinal chemistry.
[121] Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine. , 2000, Bioorganic & medicinal chemistry letters.
[122] S. McCreedy,et al. N-nitro-L-arginine and N-monomethyl-L-arginine exhibit a different pattern of inactivation toward the three nitric oxide synthases. , 1995, Archives of biochemistry and biophysics.
[123] P. Martásek,et al. Synthesis and evaluation of peptidomimetics as selective inhibitors and active site probes of nitric oxide synthases. , 2000, Journal of medicinal chemistry.
[124] S. Ueno,et al. Distribution of Free Methylarginines in Rat Tissues and in the Bovine Brain , 1992, Journal of neurochemistry.
[125] C. Nathan,et al. Identification of arginine as a precursor of endothelium-derived relaxing factor. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[126] R. Komers,et al. Role of neuronal nitric oxide synthase (NOS1) in the pathogenesis of renal hemodynamic changes in diabetes. , 2000, American journal of physiology. Renal physiology.
[127] B. Masters,et al. Nω-Nitroarginine-Containing Dipeptide Amides. Potent and Highly Selective Inhibitors of Neuronal Nitric Oxide Synthase , 1999 .
[128] O. Griffith,et al. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. , 1998, The Journal of biological chemistry.
[129] E. Chinje,et al. S-2-amino-5-azolylpentanoic acids related to L-ornithine as inhibitors of the isoforms of nitric oxide synthase (NOS). , 1998, Bioorganic & medicinal chemistry.
[130] N. Patel,et al. GW274150, a potent and highly selective inhibitor of iNOS, reduces experimental renal ischemia/reperfusion injury. , 2003, Kidney international.
[131] M. Currie,et al. A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[132] K. Boje,et al. Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death , 1992, Brain Research.
[133] J. Adams,et al. hypotension: Implications for the involvement of nitric oxide , 2022 .
[134] P. Martásek,et al. Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase. , 2001, Journal of medicinal chemistry.
[135] Haitao Ji,et al. Selective neuronal nitric oxide synthase inhibitors. , 2005, Current topics in medicinal chemistry.
[136] M. Marletta,et al. Characterization of the inactivation of nitric oxide synthase by NG-methyl-L-arginine: evidence for heme loss. , 1994, Biochemistry.
[137] M. Nyberg,et al. Low blood flow at onset of moderate-intensity exercise does not limit muscle oxygen uptake. , 2010, American journal of physiology. Regulatory, integrative and comparative physiology.
[138] K. Guntupalli,et al. Pharmacokinetics of the nitric oxide synthase inhibitor L‐NG‐methylarginine hydrochloride in patients with septic shock , 1999, Clinical pharmacology and therapeutics.
[139] J. Fukuto,et al. Inhibition of purified nitric oxide synthase from rat cerebellum and macrophage by L-arginine analogs. , 1994, Archives of biochemistry and biophysics.
[140] S. Moncada,et al. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo , 1990, British journal of pharmacology.
[141] P. Vallance,et al. Nitric oxide and cardiovascular control , 1993, Experimental physiology.
[142] B Testa,et al. In silico pharmacology for drug discovery: applications to targets and beyond , 2007, British journal of pharmacology.
[143] E. Garvey,et al. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. , 1994, The Journal of biological chemistry.
[144] R. Silverman. Design of selective neuronal nitric oxide synthase inhibitors for the prevention and treatment of neurodegenerative diseases. , 2009, Accounts of chemical research.
[145] E. Mazzon,et al. Beneficial effects of GW274150, a novel, potent and selective inhibitor of iNOS activity, in a rodent model of collagen-induced arthritis. , 2002, European journal of pharmacology.
[146] S. Wolf. The protein arginine methyltransferase family: an update about function, new perspectives and the physiological role in humans , 2009, Cellular and Molecular Life Sciences.
[147] E. Kun. Enzyme Inhibitors , 1967, Nature.
[148] J. le Gall,et al. Cardiovascular effects of the nitric oxide synthase inhibitor NG-methyl-l-arginine hydrochloride (546C88) in patients with septic shock: Results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002)* , 2004, Critical care medicine.
[149] Ryosuke Ijuin,et al. Evaluation of 3-substituted arginine analogs as selective inhibitors of human nitric oxide synthase isozymes. , 2005, Bioorganic & medicinal chemistry letters.
[150] S. Daff. NO synthase: structures and mechanisms. , 2010, Nitric oxide : biology and chemistry.
[151] P. Kubes,et al. Nitric oxide: an endogenous modulator of leukocyte adhesion. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[152] T. Fulmer. Rethinking mechanisms of drug discovery , 2011 .
[153] S. Cuzzocrea,et al. A novel, potent and selective inhibitor of the activity of inducible nitric oxide synthase (GW274150) reduces the organ injury in hemorrhagic shock. , 2002, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
[154] L. Ignarro,et al. Constitutive nitric oxide synthase from cerebellum is reversibly inhibited by nitric oxide formed from L-arginine. , 1992, Biochemical and biophysical research communications.
[155] P. Vallance,et al. Cardiovascular Biology of the Asymmetric Dimethylarginine:Dimethylarginine Dimethylaminohydrolase Pathway , 2004, Arteriosclerosis, thrombosis, and vascular biology.
[156] J. Loscalzo,et al. Nitric oxide and its role in the cardiovascular system. , 1995, Progress in cardiovascular diseases.
[157] Hiroshi Nishimune,et al. Motoneuron Death Triggered by a Specific Pathway Downstream of Fas Potentiation by ALS-Linked SOD1 Mutations , 2002, Neuron.
[158] S. Moncada,et al. Endogenous Dimethylarginine as an Inhibitor of Nitric Oxide Synthesis , 1992, Journal of cardiovascular pharmacology.
[159] G. Oliva,et al. Virtual screening and its integration with modern drug design technologies. , 2008, Current medicinal chemistry.
[160] M. Marletta,et al. Potent and selective inhibition of neuronal nitric oxide synthase by N(ω)-propyl-L-arginine , 1997 .
[161] O. Griffith,et al. Nitric oxide synthase inhibitors: amino acids. , 1996, Methods in enzymology.
[162] C. Alling,et al. Role of nitric oxide in ethanol-induced up-regulation of muscarinic acetylcholine receptors in SH-SY5Y cells. , 2001, Alcoholism, clinical and experimental research.
[163] S. Schwartz,et al. Pharmacokinetics, disposition and metabolism of 546C88 (L-NG-methylarginine hydrochloride) in rat and dog. , 1997, Xenobiotica; the fate of foreign compounds in biological systems.
[164] O. Griffith,et al. S-alkyl-L-thiocitrullines. Potent stereoselective inhibitors of nitric oxide synthase with strong pressor activity in vivo , 1995, The Journal of Biological Chemistry.
[165] S. Moncada,et al. Inhibition of nitric oxide synthase as a potential therapeutic target. , 1999, Annual review of pharmacology and toxicology.
[166] P. Martásek,et al. Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. , 2003, Journal of medicinal chemistry.
[167] P Rhodes,et al. Roles of nitric oxide in tumor growth. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[168] R. Böger. Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, explains the "L-arginine paradox" and acts as a novel cardiovascular risk factor. , 2004, The Journal of nutrition.
[169] Y. Wang,et al. Pharmacokinetics, metabolism and excretion of an inhibitor of inducible nitric oxide synthase, L-NIL-TA, in dog , 2003, Xenobiotica; the fate of foreign compounds in biological systems.
[170] D. Yates,et al. Endogenous nitric oxide is decreased in asthmatic patients by an inhibitor of inducible nitric oxide synthase. , 1996, American journal of respiratory and critical care medicine.
[171] M. Currie,et al. Nitric oxide: a key mediator in the early and late phase of carrageenan‐induced rat paw inflammation , 1996, British journal of pharmacology.
[172] D. J. Wolff,et al. Inactivation of nitric oxide synthase isoforms by diaminoguanidine and NG-amino-L-arginine. , 1996, Archives of biochemistry and biophysics.
[173] R. Komers,et al. Effects of systemic inhibition of neuronal nitric oxide synthase in diabetic rats. , 2000, Hypertension.
[174] Role of nitric oxide in local blood flow control in the anaesthetized dog , 1992, Pflügers Archiv.
[175] J. Lorente,et al. L‐arginine pathway in the sepsis syndrome , 1993, Critical care medicine.
[176] L. Navar,et al. Neuronal nitric oxide synthase modulates rat renal microvascular function. , 1998, The American journal of physiology.
[177] J. Olesen,et al. Nitric Oxide Synthase Inhibition: A New Principle in the Treatment of Migraine Attacks , 1998, Cephalalgia : an international journal of headache.