论文信息 - VISCOSUPPLEMENTATION IN OSTEOARTHRITIS

VISCOSUPPLEMENTATION IN OSTEOARTHRITIS

Viscosupplementation is a new therapy for the treatment of OA and refers to the i.a. injection of hyaluronic acid (HA), a high molecular weight polysaccharide which is a major component of synovial fluid and cartilage, in order to relieve pain and improve function; In OA, the molecular weight and concentration of HA are diminished. The concept of viscosupplementation is based on the hypothesis that IA injections of HA could help restore the viscoelasticity of the synovial fluid and promote the endogenous synthesis of a higer molecular weight and possibly more functional hyaluronan, thereby improving mobility and articular function, and reducing pain. Hyaluronan and its derivatives to have a structure modifying action by retarding structural progression in OA of the knee is considered.

M. Banciu | P. Tuduce | L. Marian

[1] R. Petrella. Hyaluronic Acid for the Treatment of Knee Osteoarthritis: Long-Term Outcomes from a Naturalistic Primary Care Experience , 2005, American journal of physical medicine & rehabilitation.

[2] R. Petrella,et al. Intra-articular Hyaluronic Acid Treatment for Golfer's Toe , 2004, The Physician and sportsmedicine.

[3] M. Dougados,et al. Intra-articular treatments in osteoarthritis: from the symptomatic to the structure modifying , 2004, Annals of the Rheumatic Diseases.

[4] P. Gishen,et al. A ONE‐YEAR, RANDOMISED, PLACEBO (SALINE) CONTROLLED CLINICAL TRIAL OF 500–730 KDA SODIUM HYALURONATE (HYALGAN®) ON THE RADIOLOGICAL CHANGE IN OSTEOARTHRITIS OF THE KNEE , 2003, International journal of clinical practice.