Fasting and bed rest, even for a relatively short period, are risk factors for ceftriaxone‐associated pseudolitiasis

Cholelithiasis is one of the side‐effects of ceftriaxone (CTRX). Reportedly, the cholelithiasis resolves relatively soon after cessation of CTRX, hence, it is called pseudolithiasis. Previous reports have suggested that biliary pseudolithiasis can cause not only gallstone attacks, but also severe adverse events, such as cholecystitis and pancreatitis. The purpose of this study was to prospectively elucidate the risk factors and clinical features of CTRX‐associated pseudolithiasis in pediatric patients.

[1]  J. Hyams,et al.  Pediatric Gastrointestinal and Liver Disease , 2015 .

[2]  R. N. Brogden,et al.  Cefuroxime: A Review of its Antibacterial Activity, Pharmacological Properties and Therapeutic Use , 2012, Drugs.

[3]  D. Fishman,et al.  79 – Diseases of the Gallbladder , 2011 .

[4]  A. Capuano,et al.  Ceftriaxone-Induced Pancreatitis in a Pediatric Patient: Case Report , 2010, Journal of chemotherapy.

[5]  N. Endo,et al.  Clinical Features of Ceftriaxone-associated Biliary Pseudolithiasis in Children , 2006 .

[6]  S. Karasalihoǧlu,et al.  Ceftriaxone‐associated biliary pseudolithiasis in children , 2006, Journal of clinical ultrasound : JCU.

[7]  Sendia Kim,et al.  Acute necrotizing cholecystitis: a rare complication of ceftriaxone-associated pseudolithiasis , 2006, Pediatric Surgery International.

[8]  A. Randolph,et al.  International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics* , 2005, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

[9]  S. Gündoğdu,et al.  Gallbladder and urinary tract precipitations associated with ceftriaxone therapy in children: a prospective study , 2004, Annals of tropical paediatrics.

[10]  A. Somer,et al.  Sonographic assessment of ceftriaxone‐associated biliary pseudolithiasis in children , 2000, Journal of clinical ultrasound : JCU.

[11]  S. Efremidis,et al.  Incidence of ceftriaxone‐associated gallbladder pseudolithiasis , 1999, Acta paediatrica.

[12]  W. Schwinger,et al.  Ceftriaxon-induzierte Cholelithiasis - eine harmlose Nebenwirkung? , 1993 .

[13]  M. Riccabona,et al.  [Ceftriaxone-induced cholelithiasis--a harmless side-effect?]. , 1993, Klinische Padiatrie.

[14]  S. Lee,et al.  Ceftriaxone-associated gallbladder sludge: Identification of calcium-ceftriaxone salt as a major component of gallbladder precipitate , 1991 .

[15]  M. Shiffman,et al.  Pathogenesis of ceftriaxone-associated biliary sludge: In vitro studies of calcium-ceftriaxone binding and solubility , 1990 .

[16]  E. W. Moore,et al.  Pathogenesis of ceftriaxone-associated biliary sludge. In vitro studies of calcium-ceftriaxone binding and solubility. , 1990, Gastroenterology.

[17]  U. Schaad,et al.  REVERSIBLE CEFTRIAXONE-ASSOCIATED BILIARY PSEUDOLITHIASIS IN CHILDREN , 1988, The Lancet.

[18]  U. Schaad,et al.  Transient formation of precipitations in the gallbladder associated with ceftriaxone therapy. , 1986, Pediatric infectious disease.

[19]  R. N. Brogden,et al.  Ceftriaxone. A review of its antibacterial activity, pharmacological properties and therapeutic use. , 1984, Drugs.