THE IMMUNOHISTOLOGY OF HODGKIN’S THEIR VARIANTS DISEASE-REED-STERNBERG CELLS A N D

SUMMARY Thirty-three cases of Hodgkin’s disease were analysed by immunoalkaline phosphatase and immunoperoxidase techniques, using a monoclonal antibody panel, including markers of B-cells, T-cells, macrophages, granulocytes, and the antibody Ki-1. Hodgkin’s cells were found to express markers generally regarded as T-cell, B-cell, myeloid, or monocyte associated. Furthermore, heterogeneity of marker expression was also seen within the Hodgkin’s cell population in any single case. Morphological and immunohistological analogies between cells involved in antigen presentation and Hodgkin’s cells are described, suggesting possible relationships between these cell types. Anti-Leu MI was not found to be a particularly sensitive marker of Hodgkin’s disease under the conditions used in this study.

[1]  R. Warnke,et al.  Immunoglobulin gene rearrangements in Hodgkin's disease. , 1986, Human pathology.

[2]  I. Lauder,et al.  The demonstration of B‐cell, T‐cell and myeloid antigens in paraffin sections , 1986, The Journal of pathology.

[3]  K. Lennert,et al.  Reed-Sternberg and Hodgkin cells in lymphocyte-predominant Hodgkin's disease of nodular subtype contain J chain. , 1986, American journal of clinical pathology.

[4]  S. Poppema,et al.  Nodular lymphocyte predominance type of Hodgkin's disease is a germinal center lymphoma. , 1986, Laboratory investigation; a journal of technical methods and pathology.

[5]  H. Stein,et al.  Immunohistological analysis of human mononuclear phagocytes and dendritic cells by using monoclonal antibodies. , 1986, Laboratory investigation; a journal of technical methods and pathology.

[6]  D. Cunningham,et al.  Use of Leu M1 and antiepithelial membrane antigen monoclonal antibodies for diagnosing Hodgkin's disease. , 1986, Journal of clinical pathology.

[7]  R. Wieczorek,et al.  Leu-M1 antigen expression in T-cell neoplasia. , 1985, The American journal of pathology.

[8]  V. Diehl,et al.  Antigen presentation by Hodgkin's disease cells. , 1985, Journal of immunology.

[9]  K. Lennert,et al.  The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. , 1985, Blood.

[10]  J. Said,et al.  Lymphomatoid papulosis. A cutaneous proliferation of activated helper T cells expressing Hodgkin's disease-associated antigens. , 1985, The American journal of pathology.

[11]  E. Jaffe,et al.  Phenotypic expression of Hodgkin's and Reed-Sternberg cells in Hodgkin's disease. , 1985, The American journal of pathology.

[12]  N. Hogg,et al.  Monoclonal antibodies specific for human monocytes, granulocytes and endothelium. , 1984, Immunology.

[13]  H. Stein,et al.  HUMAN LYMPHOID CELLS EXPRESS EPITHELIAL MEMBRANE ANTIGEN Implications for Diagnosis of Human Neoplasms , 1984, The Lancet.

[14]  V. Diehl,et al.  Interleukin-1-like activity constitutively generated by Hodgkin derived cell lines. I. Measurement in a human lymphocyte co-stimulator assay. , 1984, Immunobiology.

[15]  H. Stein,et al.  An immunohistological study of the cellular constituents of Hodgkin's disease using a monoclonal antibody panel , 1984, Histopathology.

[16]  H. Stein,et al.  Production of a monoclonal antibody reactive with human dendritic reticulum cells and its use in the immunohistological analysis of lymphoid tissue. , 1983, Journal of clinical pathology.

[17]  Johannes Gerdes,et al.  Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation , 1983, International journal of cancer.

[18]  V. Diehl,et al.  Identification of Hodgkin and sternberg‐reed cells as a unique cell type derived from a newly‐detected small‐cell population , 1982, International journal of cancer.

[19]  H. Stein,et al.  The normal and malignant germinal centre. , 1982, Clinics in haematology.

[20]  V. Diehl,et al.  Production of a monoclonal antibody specific for Hodgkin and Sternberg–Reed cells of Hodgkin's disease and a subset of normal lymphoid cells , 1982, Nature.

[21]  J. Kearney,et al.  A monoclonal antibody (MMA) that identifies a differentiation antigen on human myelomonocytic cells. , 1982, Clinical immunology and immunopathology.

[22]  M. Kadin.  Possible origin of the Reed-Sternberg cell from an interdigitating reticulum cell. , 1982, Cancer treatment reports.

[23]  D. Wright,et al.  Macrophage origin of Reed-Sternberg cells: an immunohistochemical study , 1982, Journal of clinical pathology.

[24]  E. Reinherz,et al.  In situ immunologic characterization of cellular constituents in lymph nodes and spleens involved by Hodgkin's disease. , 1982, Blood.

[25]  A. McMichael,et al.  Monoclonal Antibody to Human Platelet Glycoprotein I I. IMMUNOLOGICAL STUDIES , 1981, British journal of haematology.

[26]  C. Balch,et al.  A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1). , 1981, Journal of immunology.

[27]  S. Poppema.  The diversity of the immunohistological staining pattern of Sternberg-Reed cells. , 1980, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[28]  S. Mehta,et al.  T-lymphocyte/monocyte interaction in response to phytohemagglutinin. , 1979, Cellular immunology.

[29]  B. Mepham,et al.  The use of proteolytic enzymes to improve immunoglobulin staining by the PAP technique , 1979, The Histochemical Journal.

[30]  C. Taylor.  The nature of Reed-Sternberg cells and other malignant "reticulum" cells. , 1974, Lancet.

[31]  L. Craver,et al.  Report of the Nomenclature Committee , 1966 .

[32]  R. Lukes,et al.  The pathology and nomenclature of Hodgkin's disease. , 1966, Cancer research.

[33]  K. Maclennan,et al.  The prognostic significance of cellular subtypes in nodular sclerosing Hodgkin's disease: an analysis of 271 non-laparotomised cases (BNLI report no. 22). , 1983, Clinical radiology.