Bacterial proteolytic complexes as therapeutic targets
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[1] Celeste B. Burness,et al. Dabigatran Etexilate , 2012, Drugs.
[2] Camilla Rodrigues,et al. Totally drug-resistant tuberculosis in India. , 2012, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
[3] A. Goldberg,et al. Mycobacterium tuberculosis ClpP1 and ClpP2 Function Together in Protein Degradation and Are Required for Viability in vitro and During Infection , 2012, PLoS pathogens.
[4] Jonas Boström,et al. Oxadiazoles in medicinal chemistry. , 2012, Journal of medicinal chemistry.
[5] Ying Zhang,et al. Pyrazinamide Inhibits Trans-Translation in Mycobacterium tuberculosis , 2011, Science.
[6] P. Mazodier,et al. Acyl depsipeptide (ADEP) resistance in Streptomyces. , 2011, Microbiology.
[7] P. Niyomrattanakit,et al. The natural product cyclomarin kills Mycobacterium tuberculosis by targeting the ClpC1 subunit of the caseinolytic protease. , 2011, Angewandte Chemie.
[8] F. Narberhaus,et al. The Escherichia coli replication inhibitor CspD is subject to growth‐regulated degradation by the Lon protease , 2011, Molecular microbiology.
[9] Petra Schneider,et al. Inhibitors of Helicobacter pylori Protease HtrA Found by ‘Virtual Ligand’ Screening Combat Bacterial Invasion of Epithelia , 2011, PloS one.
[10] Sprint Investigators,et al. Boceprevir for Untreated Chronic HCV Genotype 1 Infection , 2011 .
[11] E. Benarroch. Heat shock proteins , 2011, Neurology.
[12] Qun Ma,et al. Antitoxin MqsA Helps Mediate the Bacterial General Stress Response , 2011, Nature chemical biology.
[13] C. Sarrazin,et al. New HCV therapies on the horizon. , 2011, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
[14] O. Coux,et al. Proteasome inhibitors: Dozens of molecules and still counting. , 2010, Biochimie.
[15] G. Schneider,et al. Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E‐cadherin to disrupt intercellular adhesion , 2010, EMBO reports.
[16] R. Ghirlando,et al. Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: A model for the ClpX/ClpA-bound state of ClpP. , 2010, Chemistry & biology.
[17] G. Salvesen,et al. Emerging principles in protease-based drug discovery , 2010, Nature Reviews Drug Discovery.
[18] J. Dziadek,et al. Mycobacterium tuberculosis ClpX Interacts with FtsZ and Interferes with FtsZ Assembly , 2010, PloS one.
[19] Chuan Wang,et al. Role of spx in biofilm formation of Staphylococcus epidermidis. , 2010, FEMS immunology and medical microbiology.
[20] Rebecca Page,et al. Escherichia coli toxin/antitoxin pair MqsR/MqsA regulate toxin CspD. , 2010, Environmental microbiology.
[21] H. Song,et al. Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism , 2010, Nature Structural &Molecular Biology.
[22] V. Sperandio,et al. Anti-virulence strategies to combat bacteria-mediated disease , 2010, Nature Reviews Drug Discovery.
[23] Bernd Bukau,et al. Principles of general and regulatory proteolysis by AAA+ proteases in Escherichia coli. , 2009, Research in microbiology.
[24] Zeljka Maglica,et al. Clp chaperone-proteases: structure and function. , 2009, Research in microbiology.
[25] Huilin Li,et al. Inhibitors Selective for Mycobacterial versus Human Proteasomes , 2009, Nature.
[26] S. Imbeaud,et al. Global Analysis of Extracytoplasmic Stress Signaling in Escherichia coli , 2009, PLoS genetics.
[27] C. Ottmann,et al. Peptidic small molecule activators of the stress sensor DegS. , 2009, Molecular bioSystems.
[28] S. Sieber,et al. β‐Lactones Decrease the Intracellular Virulence of Listeria monocytogenes in Macrophages , 2009, ChemMedChem.
[29] J. Hoskins,et al. ClpXP protease degrades the cytoskeletal protein, FtsZ, and modulates FtsZ polymer dynamics , 2009, Proceedings of the National Academy of Sciences.
[30] H. Lilie,et al. The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease , 2009, EMBO molecular medicine.
[31] H. Skovierová,et al. Salmonella enterica Serovar Typhimurium HtrA: regulation of expression and role of the chaperone and protease activities during infection. , 2009, Microbiology.
[32] L. Dick,et al. Distinct Specificities of Mycobacterium tuberculosis and Mammalian Proteasomes for N-Acetyl Tripeptide Substrates* , 2008, Journal of Biological Chemistry.
[33] S. Gygi,et al. Ubiquitin-Like Protein Involved in the Proteasome Pathway of Mycobacterium tuberculosis , 2008, Science.
[34] Lucy Shapiro,et al. A bacterial control circuit integrates polar localization and proteolysis of key regulatory proteins with a phospho-signaling cascade , 2008, Proceedings of the National Academy of Sciences.
[35] S. Sieber,et al. Beta-lactones as specific inhibitors of ClpP attenuate the production of extracellular virulence factors of Staphylococcus aureus. , 2008, Journal of the American Chemical Society.
[36] R. Sauer,et al. Recognition of misfolded proteins by Lon, a AAA(+) protease. , 2008, Genes & development.
[37] S. Sieber,et al. Beta-lactones as privileged structures for the active-site labeling of versatile bacterial enzyme classes. , 2008, Angewandte Chemie.
[38] S. Gottesman,et al. Multiple pathways for regulation of σS (RpoS) stability in Escherichia coli via the action of multiple anti‐adaptors , 2008, Molecular microbiology.
[39] A. Blanc-Potard,et al. Peptide‐assisted degradation of the Salmonella MgtC virulence factor , 2008, The EMBO journal.
[40] A. Coates,et al. Novel approaches to developing new antibiotics for bacterial infections , 2007, British journal of pharmacology.
[41] A. Blanc-Potard,et al. MgtC: a key player in intramacrophage survival. , 2007, Trends in microbiology.
[42] H. Ingmer,et al. Clp ATPases and ClpP proteolytic complexes regulate vital biological processes in low GC, Gram‐positive bacteria , 2007, Molecular microbiology.
[43] T. Langer,et al. Protein Degradation within Mitochondria: Versatile Activities of AAA Proteases and Other Peptidases , 2007, Critical reviews in biochemistry and molecular biology.
[44] Patrick T McGrath,et al. A phospho-signaling pathway controls the localization and activity of a protease complex critical for bacterial cell cycle progression. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[45] J. Hudak,et al. Identification of the proteasome inhibitor MG262 as a potent ATP-dependent inhibitor of the Salmonella enterica serovar Typhimurium Lon protease. , 2006, Biochemistry.
[46] S. Butler,et al. Self‐compartmentalized bacterial proteases and pathogenesis , 2006, Molecular microbiology.
[47] Markus Meister,et al. The molecular architecture of the metalloprotease FtsH. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[48] J. Schneider-Mergener,et al. ClpS is an essential component of the N-end rule pathway in Escherichia coli , 2006, Nature.
[49] T. Silhavy,et al. The extracytoplasmic adaptor protein CpxP is degraded with substrate by DegP. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[50] H. Sahl,et al. Dysregulation of bacterial proteolytic machinery by a new class of antibiotics , 2005, Nature Medicine.
[51] T. Baker,et al. Remodeling protein complexes: Insights from the AAA+ unfoldase ClpX and Mu transposase , 2005, Protein science : a publication of the Protein Society.
[52] M. Parker,et al. The HtrA Protease of Campylobacter jejuni Is Required for Heat and Oxygen Tolerance and for Optimal Interaction with Human Epithelial Cells , 2005, Applied and Environmental Microbiology.
[53] K. Kim,et al. Structure and function of HtrA family proteins, the key players in protein quality control. , 2005, Journal of biochemistry and molecular biology.
[54] C. Patten,et al. RpoS-Regulated Genes of Escherichia coli Identified by Random lacZ Fusion Mutagenesis , 2004, Journal of bacteriology.
[55] E. Isogai,et al. Degradation of the HilC and HilD regulator proteins by ATP‐dependent Lon protease leads to downregulation of Salmonella pathogenicity island 1 gene expression , 2004, Molecular microbiology.
[56] E. Silva-Herzog,et al. The ATP‐dependent ClpXP and Lon proteases regulate expression of the Yersinia pestis type III secretion system via regulated proteolysis of YmoA, a small histone‐like protein , 2004, Molecular microbiology.
[57] C. Gross,et al. Fine-tuning of the Escherichia coli sigmaE envelope stress response relies on multiple mechanisms to inhibit signal-independent proteolysis of the transmembrane anti-sigma factor, RseA. , 2004, Genes & development.
[58] H. Ohtake,et al. Effects of Inorganic Polyphosphate on the Proteolytic and DNA-binding Activities of Lon in Escherichia coli* , 2004, Journal of Biological Chemistry.
[59] M. Woodward,et al. Role of the Two-Component Regulator CpxAR in the Virulence of Salmonella enterica Serotype Typhimurium , 2004, Infection and Immunity.
[60] Tim Clausen,et al. Crystal Structure of the DegS Stress Sensor How a PDZ Domain Recognizes Misfolded Protein and Activates a Protease , 2004, Cell.
[61] A. Wlodawer,et al. The Catalytic Domain of Escherichia coli Lon Protease Has a Unique Fold and a Ser-Lys Dyad in the Active Site* , 2004, Journal of Biological Chemistry.
[62] J. Withey,et al. A Salvage Pathway for Protein Synthesis: tmRNA and Trans-Translation , 2003 .
[63] H. Ingmer,et al. Alternative roles of ClpX and ClpP in Staphylococcus aureus stress tolerance and virulence , 2003, Molecular microbiology.
[64] C. Supuran,et al. Bacterial protease inhibitors , 2002, Medicinal research reviews.
[65] J. D. Di Santo,et al. Stress-Induced ClpP Serine Protease ofListeria monocytogenes Is Essential for Induction of Listeriolysin O-Dependent Protective Immunity , 2001, Infection and Immunity.
[66] C. Craik,et al. Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[67] A. Goldberg,et al. Why Does Threonine, and Not Serine, Function as the Active Site Nucleophile in Proteasomes?* , 2000, The Journal of Biological Chemistry.
[68] P. Berche,et al. The ClpP serine protease is essential for the intracellular parasitism and virulence of Listeria monocytogenes , 2000, Molecular microbiology.
[69] A. Lupas,et al. Structure and mechanism of ATP-dependent proteases. , 1999, Current opinion in chemical biology.
[70] R. Hengge-aronis,et al. Regulation of RpoS proteolysis in Escherichia coli: the response regulator RssB is a recognition factor that interacts with the turnover element in RpoS. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[71] E V Koonin,et al. AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes. , 1999, Genome research.
[72] S. Gottesman,et al. Regulation of Proteolysis of the Stationary-Phase Sigma Factor RpoS , 1998, Journal of bacteriology.
[73] L. Shapiro,et al. Negative control of bacterial DNA replication by a cell cycle regulatory protein that binds at the chromosome origin. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[74] T. Silhavy,et al. Transduction of envelope stress in Escherichia coli by the Cpx two-component system , 1997, Journal of bacteriology.
[75] S. Gottesman,et al. Regulatory Subunits of Energy-Dependent Proteases , 1997, Cell.
[76] W Baumeister,et al. Self-compartmentalizing proteases. , 1997, Trends in biochemical sciences.
[77] D. Markovitz,et al. Bacterial Protease Lon Is a Site-specific DNA-binding Protein* , 1997, The Journal of Biological Chemistry.
[78] Koreaki Ito,et al. FtsH (HflB) Is an ATP-dependent Protease Selectively Acting on SecY and Some Other Membrane Proteins* , 1996, The Journal of Biological Chemistry.
[79] A. Goldberg,et al. HslV-HslU: A novel ATP-dependent protease complex in Escherichia coli related to the eukaryotic proteasome. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[80] H. Mori,et al. Escherichia coli FtsH is a membrane‐bound, ATP‐dependent protease which degrades the heat‐shock transcription factor sigma 32. , 1995, The EMBO journal.
[81] S. Morimura,et al. The Escherichia coli FtsH protein is a prokaryotic member of a protein family of putative ATPases involved in membrane functions, cell cycle control, and gene expression , 1993, Journal of bacteriology.
[82] J. Tobias,et al. The N-end rule in bacteria. , 1991, Science.
[83] F. Eisenmenger,et al. A fast unbiased comparison of protein structures by means of the Needleman-Wunsch algorithm , 1991, Journal of Molecular Evolution.
[84] S. Gottesman,et al. The ClpP component of Clp protease is the sigma 32-dependent heat shock protein F21.5 , 1990, Journal of bacteriology.
[85] S. Gottesman,et al. Clp P represents a unique family of serine proteases. , 1990, The Journal of biological chemistry.
[86] C. Georgopoulos,et al. The HtrA (DegP) protein, essential for Escherichia coli survival at high temperatures, is an endopeptidase , 1990, Journal of bacteriology.
[87] C. Georgopoulos,et al. Identification, characterization, and mapping of the Escherichia coli htrA gene, whose product is essential for bacterial growth only at elevated temperatures , 1989, Journal of bacteriology.
[88] C. Georgopoulos,et al. Sequence analysis and regulation of the htrA gene of Escherichia coli: a sigma 32-independent mechanism of heat-inducible transcription. , 1988, Nucleic acids research.
[89] S. Gottesman,et al. Insertional mutagenesis of the lon gene in Escherichia coli: lon is dispensable , 1985, Journal of bacteriology.
[90] A. Goldberg,et al. Heat shock regulatory gene htpR influences rates of protein degradation and expression of the lon gene in Escherichia coli. , 1984, Proceedings of the National Academy of Sciences of the United States of America.
[91] G. Wiseman. The hemolysins of Staphylococcus aureus , 1975, Bacteriological reviews.
[92] H. Kowarzyk. Structure and Function. , 1910, Nature.
[93] M. Manns,et al. Boceprevir for untreated chronic HCV genotype 1 infection. , 2011, The New England journal of medicine.
[94] P. Richardson,et al. Bortezomib in the treatment of multiple myeloma , 2011 .
[95] D. Pompliano,et al. Drugs for bad bugs: confronting the challenges of antibacterial discovery , 2007, Nature Reviews Drug Discovery.
[96] J. Maupin-Furlow,et al. Proteasomes from structure to function: perspectives from Archaea. , 2006, Current topics in developmental biology.
[97] P. Cossart,et al. The listeriolysin O gene: A chromosomal locus crucial for the virulence of Listeria monocytogenes , 2005, Infection.
[98] J. Withey,et al. A salvage pathway for protein structures: tmRNA and trans-translation. , 2003, Annual review of microbiology.
[99] C. Sohaskey,et al. Nonreplicating persistence of mycobacterium tuberculosis. , 2001, Annual review of microbiology.
[100] R. Huber,et al. The structures of HsIU and the ATP-dependent protease HsIU-HsIV. , 2000, Nature.
[101] N. Thornberry,et al. A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE). , 1997, Chemistry & biology.
[102] A. Plaut. The IgA1 proteases of pathogenic bacteria. , 1983, Annual review of microbiology.
[103] A. Goldberg,et al. Intracellular protein degradation in mammalian and bacterial cells: Part 2. , 1976, Annual review of biochemistry.
[104] A. Goldberg,et al. Intracellular protein degradation in mammalian and bacterial cells. , 1974, Annual review of biochemistry.