Hepatitis C virus structural proteins can exacerbate or ameliorate acetaminophen-induced liver injury in mice

[1]  Takao Iwawaki,et al.  CHOP is a critical regulator of acetaminophen-induced hepatotoxicity. , 2013, Journal of hepatology.

[2]  Mitchell R. McGill,et al.  Fas receptor-deficient lpr mice are protected against acetaminophen hepatotoxicity due to higher glutathione synthesis and enhanced detoxification of oxidant stress. , 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[3]  Hartmut Jaeschke,et al.  Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications. , 2013, Toxicology and applied pharmacology.

[4]  Fei Li,et al.  Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity. , 2013, Chemical research in toxicology.

[5]  Mitchell R. McGill,et al.  Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis , 2013, Pharmaceutical Research.

[6]  I. Rusyn,et al.  Acetaminophen-induced acute liver injury in HCV transgenic mice. , 2013, Toxicology and applied pharmacology.

[7]  Mitchell R. McGill,et al.  Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury. , 2012, Toxicological sciences : an official journal of the Society of Toxicology.

[8]  H. Jaeschke,et al.  Autophagy and acetaminophen hepatotoxicity: how useful are Atg7-deficient mice? , 2012, Journal of Gastroenterology.

[9]  Hartmut Jaeschke,et al.  The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation. , 2012, The Journal of clinical investigation.

[10]  Y. Igusa,et al.  Loss of autophagy promotes murine acetaminophen hepatotoxicity , 2012, Journal of gastroenterology.

[11]  Mitchell R. McGill,et al.  Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity , 2012, Drug metabolism reviews.

[12]  H. Jaeschke,et al.  Activation of autophagy protects against acetaminophen‐induced hepatotoxicity , 2012, Hepatology.

[13]  H. Jaeschke,et al.  Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity. , 2011, Toxicological sciences : an official journal of the Society of Toxicology.

[14]  Hartmut Jaeschke,et al.  Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products. , 2011, Life sciences.

[15]  L. MacMillan-Crow,et al.  Acetaminophen-Induced Hepatotoxicity in Mice Occurs with Inhibition of Activity and Nitration of Mitochondrial Manganese Superoxide Dismutase , 2011, Journal of Pharmacology and Experimental Therapeutics.

[16]  H. Jaeschke,et al.  The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity. , 2011, Toxicology and applied pharmacology.

[17]  H. Jaeschke,et al.  Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury , 2011, Free radical research.

[18]  H. Jaeschke,et al.  Acetaminophen‐induced hepatic neutrophil accumulation and inflammatory liver injury in CD18‐deficient mice , 2010, Liver international : official journal of the International Association for the Study of the Liver.

[19]  H. Jaeschke,et al.  The oxygen tension modulates acetaminophen-induced mitochondrial oxidant stress and cell injury in cultured hepatocytes. , 2010, Toxicological sciences : an official journal of the Society of Toxicology.

[20]  H. Jaeschke,et al.  c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity. , 2010, Toxicology and applied pharmacology.

[21]  William M. Lee,et al.  Susceptibility to acetaminophen (APAP) toxicity unexpectedly is decreased during acute viral hepatitis in mice. , 2010, Biochemical pharmacology.

[22]  H. Jaeschke,et al.  Mechanism of protection by metallothionein against acetaminophen hepatotoxicity. , 2010, Toxicology and applied pharmacology.

[23]  C. Rice,et al.  Towards a small animal model for hepatitis C , 2009, EMBO reports.

[24]  S. Manabe,et al.  Sensitivity of Liver Injury in Heterozygous Sod2 Knockout Mice Treated with Troglitazone or Acetaminophen , 2009, Toxicologic pathology.

[25]  Justina J. Sam,et al.  Hepatitis C is a predictor of acute liver injury among hospitalizations for acetaminophen overdose in the United States: A nationwide analysis , 2008, Hepatology.

[26]  M. Karin,et al.  Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation. , 2008, Gastroenterology.

[27]  Neil Kaplowitz,et al.  Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury* , 2008, Journal of Biological Chemistry.

[28]  W. Zong,et al.  Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress , 2008, Cell Death and Differentiation.

[29]  H. Jaeschke,et al.  Mitochondrial Bax Translocation Accelerates DNA Fragmentation and Cell Necrosis in a Murine Model of Acetaminophen Hepatotoxicity , 2008, Journal of Pharmacology and Experimental Therapeutics.

[30]  C. Yeh,et al.  Acute expression of hepatitis C core protein in adult mouse liver: Mitochondrial stress and apoptosis , 2008, Scandinavian journal of gastroenterology.

[31]  Dean P. Jones,et al.  Mitochondrial thioredoxin-2/peroxiredoxin-3 system functions in parallel with mitochondrial GSH system in protection against oxidative stress. , 2007, Archives of biochemistry and biophysics.

[32]  G. Nagy,et al.  Acetaminophen induces ER dependent signaling in mouse liver. , 2007, Archives of biochemistry and biophysics.

[33]  H. Jaeschke,et al.  Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.

[34]  S. Weinman,et al.  Causes and consequences of mitochondrial reactive oxygen species generation in hepatitis C , 2006, Journal of gastroenterology and hepatology.

[35]  William M. Lee,et al.  Acetaminophen‐induced acute liver failure: Results of a United States multicenter, prospective study , 2005, Hepatology.

[36]  S. Weinman,et al.  Hepatitis C Virus Core Protein Inhibits Mitochondrial Electron Transport and Increases Reactive Oxygen Species (ROS) Production* , 2005, Journal of Biological Chemistry.

[37]  H. Jaeschke,et al.  Peroxynitrite-Induced Mitochondrial and Endonuclease-Mediated Nuclear DNA Damage in Acetaminophen Hepatotoxicity , 2005, Journal of Pharmacology and Experimental Therapeutics.

[38]  R. Bartenschlager,et al.  Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletion , 2005, Oncogene.

[39]  R. Kurten,et al.  Mechanisms of Acetaminophen-Induced Hepatotoxicity: Role of Oxidative Stress and Mitochondrial Permeability Transition in Freshly Isolated Mouse Hepatocytes , 2005, Journal of Pharmacology and Experimental Therapeutics.

[40]  H. Jaeschke,et al.  Mitochondrial permeability transition in acetaminophen‐induced necrosis and apoptosis of cultured mouse hepatocytes , 2004, Hepatology.

[41]  H. Jaeschke,et al.  Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis? , 2002, Toxicological sciences : an official journal of the Society of Toxicology.

[42]  Frank Scholle,et al.  Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. , 2002, Gastroenterology.

[43]  J. Hinson,et al.  Vascular and hepatocellular peroxynitrite formation during acetaminophen toxicity: role of mitochondrial oxidant stress. , 2001, Toxicological sciences : an official journal of the Society of Toxicology.

[44]  K. Koike,et al.  Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis. , 2001, Cancer research.

[45]  K. Kang,et al.  Glutathione S-Transferase Mu Modulates the Stress-activated Signals by Suppressing Apoptosis Signal-regulating Kinase 1* , 2001, The Journal of Biological Chemistry.

[46]  S. Vonderfecht,et al.  Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: evidence for a postmitochondrial processing of caspase-8. , 2000, Toxicological sciences : an official journal of the Society of Toxicology.

[47]  J. Hayes,et al.  Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. , 1999, Free radical research.

[48]  T. Pineau,et al.  Role of CYP2E1 in the Hepatotoxicity of Acetaminophen (*) , 1996, The Journal of Biological Chemistry.

[49]  H. Jaeschke,et al.  Glutathione disulfide formation and oxidant stress during acetaminophen-induced hepatotoxicity in mice in vivo: the protective effect of allopurinol. , 1990, The Journal of pharmacology and experimental therapeutics.

[50]  S. Nelson Molecular Mechanisms of the Hepatotoxicity Caused by Acetaminophen , 1990, Seminars in liver disease.

[51]  W B Jakoby,et al.  Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. , 1974, The Journal of biological chemistry.

[52]  B B Brodie,et al.  Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. , 1973, The Journal of pharmacology and experimental therapeutics.

[53]  Mitchell R. McGill,et al.  Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation. , 2013, Toxicological sciences : an official journal of the Society of Toxicology.

[54]  T. Ueno,et al.  LC3 and Autophagy. , 2008, Methods in molecular biology.

[55]  Toshiharu Horie,et al.  Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice. , 2005, Journal of hepatology.

[56]  J. Hayes,et al.  The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. , 1995, Critical reviews in biochemistry and molecular biology.

[57]  M. Black,et al.  Acetaminophen hepatotoxicity. , 1980, Gastroenterology.

[58]  S. Thorgeirsson,et al.  Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen. , 1974, Pharmacology.