Iodide Effects on the Thyroid: Biochemical, Physiological, Pharmacological, and Clinical Effects of Iodide in the Thyroid

[1]  Haiyan S. Li,et al.  Induction of goitrous hypothyroidism by dietary iodide in SJL mice. , 2007, Endocrinology.

[2]  K. Markou,et al.  Thyroid hormone synthesis and secretion in humans after 80 milligrams of iodine for 15 days and subsequent withdrawal. , 2007, The Journal of clinical endocrinology and metabolism.

[3]  T. Jørgensen,et al.  Increase in incidence of hyperthyroidism predominantly occurs in young people after iodine fortification of salt in Denmark. , 2006, The Journal of clinical endocrinology and metabolism.

[4]  K. Takano,et al.  Iodide inhibits vascular endothelial growth factor-A expression in cultured human thyroid follicles: a microarray search for effects of thyrotropin and iodide on angiogenesis factors. , 2006, Thyroid : official journal of the American Thyroid Association.

[5]  J. Oates,et al.  Iodination of docosahexaenoic acid by lactoperoxidase and thyroid gland in vitro: Formation of an lodolactone , 1981, Lipids.

[6]  W. Hubbard,et al.  Lactoperoxidase-catalyzed lodination of arachidonic acid: Formation of macrolides , 1981, Lipids.

[7]  C. Ginter,et al.  The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance. , 2003, Endocrine reviews.

[8]  Stanislas C. Morand,et al.  Identification of a truncated dual oxidase 2 (DUOX2) messenger ribonucleic acid (mRNA) in two rat thyroid cell lines. Insulin and forskolin regulation of DUOX2 mRNA levels in FRTL-5 cells and porcine thyrocytes. , 2003, Endocrinology.

[9]  K. Takano,et al.  Genes regulated by thyrotropin and iodide in cultured human thyroid follicles: analysis by cDNA microarray. , 2003, Thyroid : official journal of the American Thyroid Association.

[10]  P. Courtoy,et al.  The endocytic catalysts, Rab5a and Rab7, are tandem regulators of thyroid hormone production , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[11]  H. Harach,et al.  Thyroid cancer and thyroiditis in Salta, Argentina: A 40-yr study in relation to iodine prophylaxis , 2002, Endocrine pathology.

[12]  A. Fusco,et al.  Regulation of thyroid cell proliferation by TSH and other factors: a critical evaluation of in vitro models. , 2001, Endocrine reviews.

[13]  E. Hindié,et al.  The perinatal thyroid in iodine deficient regions: risks of radioiodines--hazards of stable iodine overload. A study in the newborn rat. , 2001, Cellular and molecular biology.

[14]  U. Feldt-Rasmussen Iodine and cancer. , 2001, Thyroid : official journal of the American Thyroid Association.

[15]  J. Wolff Physiology and Pharmacology of Iodized Oil in Goiter Prophylaxis , 2001, Medicine.

[16]  L. Braverman,et al.  Iodine-induced hyperthyroidism: occurrence and epidemiology. , 1998, Thyroid : official journal of the American Thyroid Association.

[17]  J. Dumont,et al.  Moderate doses of iodide in vivo inhibit cell proliferation and the expression of thyroperoxidase and Na+/I− symporter mRNAs in dog thyroid , 1997, Molecular and Cellular Endocrinology.

[18]  J. Braekman,et al.  Biosynthesis and Metabolism of 2-Iodohexadecanal in Cultured Dog Thyroid Cells* , 1996, The Journal of Biological Chemistry.

[19]  J. Denef,et al.  Iodine-induced thyroid inhibition and cell necrosis: two consequences of the same free-radical mediated mechanism? , 1996, Molecular and Cellular Endocrinology.

[20]  N. Bagchi,et al.  Thyroid cell injury is an initial event in the induction of autoimmune thyroiditis by iodine in obese strain chickens. , 1995, Endocrinology.

[21]  C. Maenhaut,et al.  Large goitre as a maladaptation to iodine deficiency , 1995, Clinical endocrinology.

[22]  R. Gärtner,et al.  delta-Iodolactones decrease epidermal growth factor-induced proliferation and inositol-1,4,5-trisphosphate generation in porcine thyroid follicles--a possible mechanism of growth inhibition by iodide. , 1995, European journal of endocrinology.

[23]  L. Hofbauer,et al.  Insulin-like growth factor I messenger ribonucleic acid expression in porcine thyroid follicles is regulated by thyrotropin and iodine. , 1995, European journal of endocrinology.

[24]  J. Braekman,et al.  Inhibition of human thyroid adenylyl cyclase by 2-iodoaldehydes , 1994, Molecular and Cellular Endocrinology.

[25]  G. Bechtner,et al.  Identification of δ-Iodolactone in Iodide Treated Human Goiter and its Inhibitory Effect on Proliferation of Human Thyroid Follicles , 1994, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[26]  E. Laurent,et al.  Role of the cyclic adenosine 3',5'-monophosphate and the phosphatidylinositol-Ca2+ cascades in mediating the effects of thyrotropin and iodide on hormone synthesis and secretion in human thyroid slices. , 1994, The Journal of clinical endocrinology and metabolism.

[27]  H. Gerber,et al.  The degree of inhibition of thyroid follicular cell proliferation by iodide is a highly individual characteristic of each cell and differs profoundly in vitro and in vivo. , 1994, European journal of endocrinology.

[28]  J. Braekman,et al.  Inhibition of H2O2 production by iodoaldehydes in cultured dog thyroid cells , 1994, Molecular and Cellular Endocrinology.

[29]  J. Braekman,et al.  Inhibition of thyroid NADPH-oxidase by 2-iodohexadecanal in a cell-free system , 1994, Molecular and Cellular Endocrinology.

[30]  J. Davis,et al.  Transforming growth factor-beta 1 production in porcine thyroid follicular cells: regulation by intrathyroidal organic iodine. , 1992, Journal of molecular endocrinology.

[31]  M. Pisarev,et al.  Effect of Iodoarachidonates on Thyroid FRTL-5 Cells Growth , 1992, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[32]  G. Brabant,et al.  Early adaptation of thyrotropin and thyroglobulin secretion to experimentally decreased iodine supply in man. , 1992, Metabolism: clinical and experimental.

[33]  N. Ishikawa,et al.  Effects of iodine on thyroid status of fetus versus mother in treatment of Graves' disease complicated by pregnancy. , 1992, The Journal of clinical endocrinology and metabolism.

[34]  C. Mestdagh,et al.  In vitro study of acute toxic effects of high iodide doses in human thyroid follicles. , 1992, Endocrinology.

[35]  J. Meinkoth,et al.  Iodide Induces Transforming Growth Factor Beta1 (TGF-β1) mRNA in Sheep Thyroid Cells , 1992 .

[36]  A. Meinders,et al.  Inverse relation between iodine intake and thyroid blood flow: color Doppler flow imaging in euthyroid humans. , 1991, The Journal of clinical endocrinology and metabolism.

[37]  M. Pisarev,et al.  Thyroid autoregulation: evidence for an action of iodoarachidonates and iodide at the cell membrane level. , 1991, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[38]  E. Laurent,et al.  The H2O2-generating system modulates protein iodination and the activity of the pentose phosphate pathway in dog thyroid. , 1991, Endocrinology.

[39]  J. Braekman,et al.  Identification of a major iodolipid from the horse thyroid gland as 2-iodohexadecanal. , 1990, The Journal of biological chemistry.

[40]  G. Bechtner,et al.  Evidence that an iodolactone mediates the inhibitory effect of iodide on thyroid cell proliferation but not on adenosine 3',5'-monophosphate formation. , 1990, Endocrinology.

[41]  J. Mockel,et al.  Stimulation of generation of inositol phosphates by carbamoylcholine and its inhibition by phorbol esters and iodide in dog thyroid cells. , 1989, The Biochemical journal.

[42]  G. Burton,et al.  Thyroid autoregulation. Inhibition of goiter growth and of cyclic AMP formation in rat thyroid by iodinated derivatives of arachidonic acid , 1988, Journal of endocrinological investigation.

[43]  G. Burton,et al.  Thyroid autoregulation. Inhibitory effects of iodinated derivatives of arachidonic acid on iodine metabolism. , 1988, Prostaglandins.

[44]  G. Burton,et al.  The inhibition of PB125I formation in calf thyroid caused by 14-iodo-15-hydroxy-eicosatrienoic acid is due to decreased H2O2 availability. , 1988, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[45]  S. Swillens,et al.  Iodide-induced inhibition of adenylate cyclase activity in horse and dog thyroid. , 1987, European journal of biochemistry.

[46]  D. J. Price,et al.  Autoregulation of iodide transport in the rabbit: absence of autoregulation in fetal tissue and comparison of maternal and fetal thyroid iodination products. , 1986, Endocrinology.

[47]  S. Filetti,et al.  Thyroid autoregulation: effect of iodine on glucose transport in cultured thyroid cells. , 1986, Endocrinology.

[48]  B. Westermark,et al.  Inhibition of cyclic AMP formation by iodide in suspension cultures of porcine thyroid follicle cells , 1985, Molecular and Cellular Endocrinology.

[49]  J. Dumont,et al.  Further characterization of the iodide inhibitory effect on the cyclic AMP system in dog thyroid slices , 1985, Molecular and Cellular Endocrinology.

[50]  K. Ichikawa,et al.  Thyrotropin-induced acceleration of calcium efflux from mouse thyroid: evidence for inhibition by excess iodide. , 1984, Endocrinology.

[51]  J. Dumont,et al.  IODIDE ORGANIFICATION DEFECT IN A COLD THYROID NODULE: ABSENCE OF IODIDE EFFECT ON CYCLIC AMP ACCUMULATION , 1984, Clinical endocrinology.

[52]  B. Rapoport,et al.  Evidence that organic iodine attenuates the adenosine 3',5'-monophosphate response to thyrotropin stimulation in thyroid tissue by an action at or near the adenylate cyclase catalytic unit. , 1983, Endocrinology.

[53]  J. Sherwin Development of Regulatory Mechanisms in the Thyroid: Failure of Iodide to Suppress Iodide Transport Activity , 1982, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[54]  S. Tarui,et al.  Effects of iodide and propylthiouracil on the release of 3,5,3'-triiodothyronine and of cyclic adenosine 3',5'-monophosphate from perifused rat thyroids. , 1982, Endocrinology.

[55]  J. Pommier,et al.  Formation of thyroid hormones. , 1982, Vitamins and hormones.

[56]  I. Rosenberg,et al.  Effects of hydrogen peroxide-generating systems on the Wolff-Chaikoff effect. , 1981, Endocrinology.

[57]  M. Pisarev,et al.  Uptake, metabolism and action of triiodothyronine in calf-thyroid slices , 1981, Molecular and Cellular Endocrinology.

[58]  W. Hubbard,et al.  Transformation of arachidonic acid into an iodolactone by the rat thyroid. , 1980, The Journal of biological chemistry.

[59]  J. Dumont,et al.  Inhibition by iodide of the cholinergic stimulation of prostaglandin synthesis in dog thyroid. , 1979, Endocrinology.

[60]  L. Vanhaelst,et al.  Pituitary-thyroid axis during short term, mild and severe, iodine depletion in the rat. , 1978, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[61]  A. Rossier,et al.  Goitre and hypothyroidism in the newborn after cutaneous absorption of iodine. , 1978, Archives of disease in childhood.

[62]  B. Rapoport,et al.  Cultured thyroid cell adenosine 3',5'-cyclic monophosphate response to thyrotropin: loss and restoration of sensitivity to iodide inhibition. , 1977, Endocrinology.

[63]  J. Dodion,et al.  Adverse effect of amniofetography on fetal thyroid function. , 1976, American journal of obstetrics and gynecology.

[64]  L. Braverman,et al.  Adverse effects of iodides on thyroid function. , 1975, The Medical clinics of North America.

[65]  B. Rapoport,et al.  Inhibitory effect of dietary iodine on the thyroid adenylate cyclase response to thyrotropin in the hypophysectomized rat. , 1975, The Journal of clinical investigation.

[66]  J. Dumont,et al.  Inhibition by iodide of the activation of the thyroid cyclic 3',5'-AMP system. , 1975, Endocrinology.

[67]  J. Dumont,et al.  Effects of thyrotropin, prostaglandin E1 and iodide on cyclic 3',5'-AMP concentration in dog thyroid slices. , 1973, Biochimica et biophysica acta.

[68]  D. Becker,et al.  Necrosis of follicular cells and discharge of thyroidal iodine induced by administering iodide to iodine-deficient dogs. , 1973, The Journal of clinical endocrinology and metabolism.

[69]  M. Itoiz,et al.  Action of KI on stimulated thyroid protein biosynthesis. , 1972, Endocrinology.

[70]  T. Yamada,et al.  Inhibitory effect of excess iodide on thyroid hormone release as measured by intracellular colloid droplets. , 1972, Endocrinology.

[71]  L. Degroot,et al.  KI and imidazole inhibition of TSH and c-AMP induced thyroidal iodine secretion. , 1971, Endocrinology.

[72]  L. Degroot,et al.  Serum TSH and Thyroxine in Goitrous Subjects in Argentina , 1970 .

[73]  B. Ransil,et al.  Inhibition by iodine of the release of thyroxine from the thyroid glands of patients with thyrotoxicosis. , 1970, The Journal of clinical investigation.

[74]  J. Wolff Iodide goiter and the pharmacologic effects of excess iodide. , 1969, The American journal of medicine.

[75]  R. Sobel,et al.  A correlative study of the effect of iodide administration in the rat on thyroidal iodide transport and organic iodine content. , 1968, Endocrinology.

[76]  G. Bray Increased sensitivity of the thyroid in iodine-depleted rats to the goitrogenic effects of thyrotropin. , 1968, The Journal of clinical investigation.

[77]  T. Yamada,et al.  Studies on the mechanism of the inhibitory action of excess iodide on the release of radioiodine from the rat thyroid gland. , 1968, Endocrinology.

[78]  T. Yamada,et al.  Effect of excess iodide on thyroid hormone synthesis in hypophysectomized, thyrotropin administered rats. , 1966, Metabolism: clinical and experimental.

[79]  R. Harden,et al.  QUANTITATIVE STUDIES OF IODINE METABOLISM IN IODIDE-TREATED THYROTOXICOSIS. , 1964, Clinical science.

[80]  S. Ingbar,et al.  The effect of iodide on the rate of release of I-131 from autonomous thyroid nodules. , 1962, The Journal of clinical investigation.

[81]  S. Lissitzky,et al.  The presence and in vitro activity of free iodinated peptides in the thyroid gland of mammals and man. , 1961, General and comparative endocrinology.

[82]  A. Taurog,et al.  Thyroid I131 metabolism in the absence of the pituitary: the untreated, hypophysectomized rat. , 1958, Endocrinology.

[83]  Halmi Ns,et al.  Problems of thyroidal self-regulation. , 1956 .

[84]  L. Degroot,et al.  The effect of stable iodide on thyroid secretion in man. , 1956, Metabolism: clinical and experimental.

[85]  N. Freinkel,et al.  The metabolism of I131 by surviving slices of rat mammary tissue. , 1956, Endocrinology.

[86]  J. Wolff,et al.  Plasma inorganic iodide as a homeostatic regulator of thyroid function. , 1948, The Journal of biological chemistry.