Maintaining proteostasis under mechanical stress
暂无分享,去创建一个
Pitter F. Huesgen | Markus M. Rinschen | M. Hesse | T. Benzing | B. Warscheid | Dagmar Wachten | W. Bloch | M. Köhn | J. Höhfeld | R. Merkel | B. Hoffmann | W. Kolanus | W. Pokrzywa | T. Hoppe | C. Niessen | S. Gehlert | D. Fürst | D. Wachten
[1] Pitter F. Huesgen,et al. Overexpression of human BAG3P209L in mice causes restrictive cardiomyopathy , 2021, Nature Communications.
[2] A. Mankodi,et al. Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCα and TSC2-mTOR downregulation , 2021, Communications biology.
[3] Maximilian T. Strauss,et al. Quantitative single-protein imaging reveals molecular complex formation of integrin, talin, and kindlin during cell adhesion , 2021, Nature Communications.
[4] François Bordeleau,et al. Chaperone-Assisted Mitotic Actin Remodeling by BAG3 and HSPB8 Involves the Deacetylase HDAC6 and Its Substrate Cortactin , 2020, International journal of molecular sciences.
[5] M. Hipp,et al. Sis1 potentiates the stress response to protein aggregation and elevated temperature , 2020, Nature Communications.
[6] F. Santorelli,et al. Protein aggregates and autophagy involvement in a family with a mutation in Z-band alternatively spliced PDZ-motif protein , 2020, Neuromuscular Disorders.
[7] E. Malfatti,et al. Pathogenic Variants in the Myosin Chaperone UNC-45B Cause Progressive Myopathy with Eccentric Cores. , 2020, American journal of human genetics.
[8] Nadinath B. Nillegoda,et al. HSP40 proteins use class-specific regulation to drive HSP70 functional diversity , 2020, Nature.
[9] Thomas M. Kitzler,et al. Recessive Mutations in SYNPO2 as a Candidate of Monogenic Nephrotic Syndrome , 2020, Kidney international reports.
[10] M. Butte,et al. Unraveling the mechanobiology of immune cells , 2020, Current Opinion in Biotechnology.
[11] J. Schmitt,et al. Regulation of titin-based cardiac stiffness by unfolded domain oxidation (UnDOx) , 2020, Proceedings of the National Academy of Sciences.
[12] W. Linke,et al. Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin , 2020, Nature Communications.
[13] W. Bloch,et al. Coordinated CRYAB phosphorylation and desmin expression indicate adaptation and de-adaptation to resistance exercise-induced loading in human skeletal muscle. , 2020, American journal of physiology. Cell physiology.
[14] C. Kreutz,et al. Phosphoproteomics identifies dual-site phosphorylation in an extended basophilic motif regulating FILIP1-mediated degradation of filamin-C , 2020, Communications Biology.
[15] Markus M. Rinschen,et al. A molecular mechanism explaining albuminuria in kidney disease , 2020, Nature Metabolism.
[16] A. Feldman,et al. Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover , 2020, Nature Communications.
[17] H. Vihinen,et al. Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage , 2020, Cell.
[18] N. Green,et al. Drosophila NUAK functions with Starvin/BAG3 in autophagic protein turnover , 2020, PLoS genetics.
[19] Markus M. Rinschen,et al. Proteome Analysis of Isolated Podocytes Reveals Stress Responses in Glomerular Sclerosis. , 2020, Journal of the American Society of Nephrology : JASN.
[20] J. Concordet,et al. Heat Shock Factor 2 Protects against Proteotoxicity by Maintaining Cell-Cell Adhesion. , 2020, Cell reports.
[21] D. Discher,et al. Forced unfolding of proteins directs biochemical cascades. , 2019, Biochemistry.
[22] V. Weaver,et al. Tissue mechanics, an important regulator of development and disease , 2019, Philosophical Transactions of the Royal Society B.
[23] Nolan J. Hoffman,et al. Phosphoproteomics reveals conserved exercise‐stimulated signaling and AMPK regulation of store‐operated calcium entry , 2019, The EMBO journal.
[24] Nadinath B. Nillegoda,et al. The Hsp70 chaperone network , 2019, Nature Reviews Molecular Cell Biology.
[25] Pere Roca-Cusachs,et al. Integrins as biomechanical sensors of the microenvironment , 2019, Nature Reviews Molecular Cell Biology.
[26] J. Lammerding,et al. The Driving Force: Nuclear Mechanotransduction in Cellular Function, Fate, and Disease. , 2019, Annual review of biomedical engineering.
[27] W. Bloch,et al. Phosphorylation of αB-crystallin and its cytoskeleton association differs in skeletal myofiber types depending on resistance exercise intensity and volume. , 2019, Journal of applied physiology.
[28] H. Watkins,et al. HspB1 phosphorylation regulates its intramolecular dynamics and mechanosensitive molecular chaperone interaction with filamin C , 2019, Science Advances.
[29] H. Okamoto,et al. RNA-sequencing reveals altered skeletal muscle contraction, E3 ligases, autophagy, apoptosis, and chaperone expression in patients with critical illness myopathy , 2019, Skeletal Muscle.
[30] T. Benzing,et al. Glomerular podocytes in kidney health and disease , 2019, The Lancet.
[31] F. Schnorrer,et al. A small proportion of Talin molecules transmit forces at developing muscle attachments in vivo , 2019, PLoS biology.
[32] M. Sheetz,et al. Steps in Mechanotransduction Pathways that Control Cell Morphology. , 2019, Annual review of physiology.
[33] M. Hipp,et al. The proteostasis network and its decline in ageing , 2019, Nature Reviews Molecular Cell Biology.
[34] B. Asselbergh,et al. Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies , 2019, Autophagy.
[35] G. Johnson,et al. BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes , 2019, bioRxiv.
[36] M. Varjosalo,et al. Talin-mediated force transmission and talin rod domain unfolding independently regulate adhesion signaling , 2019, Journal of Cell Science.
[37] H. Kampinga,et al. Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks , 2018, Nature Communications.
[38] Samantha K. Barrick,et al. Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions , 2018, Nature Communications.
[39] J. Höhfeld,et al. The Hippo network kinase STK38 contributes to protein homeostasis by inhibiting BAG3-mediated autophagy , 2018, bioRxiv.
[40] T. Srivastava,et al. Hyperfiltration-mediated Injury in the Remaining Kidney of a Transplant Donor. , 2018, Transplantation.
[41] Jie Yan,et al. Talin as a mechanosensitive signaling hub , 2018, The Journal of cell biology.
[42] G. Dreissen,et al. Transition of responsive mechanosensitive elements from focal adhesions to adherens junctions on epithelial differentiation , 2018, Molecular biology of the cell.
[43] D. Reiner,et al. Small GTPases. , 2018, WormBook : the online review of C. elegans biology.
[44] J. Höhfeld,et al. Ub and Down: Ubiquitin Exercise for the Elderly. , 2018, Trends in cell biology.
[45] Markus M. Rinschen,et al. A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes , 2018, Cell reports.
[46] P. Csermely,et al. Roles of heat shock factor 1 beyond the heat shock response , 2018, Cellular and Molecular Life Sciences.
[47] Nadinath B. Nillegoda,et al. Protein Disaggregation in Multicellular Organisms. , 2018, Trends in biochemical sciences.
[48] T. Acker,et al. Dysregulated autophagy in restrictive cardiomyopathy due to Pro209Leu mutation in BAG3. , 2018, Molecular genetics and metabolism.
[49] D. Klionsky,et al. Cargo recognition and degradation by selective autophagy , 2018, Nature Cell Biology.
[50] Pere Roca-Cusachs,et al. Mechanosensing at integrin-mediated cell-matrix adhesions: from molecular to integrated mechanisms. , 2018, Current opinion in cell biology.
[51] W. Linke,et al. Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes , 2018, Nature Communications.
[52] L. Larsson,et al. Weak by the machines: muscle motor protein dysfunction – a side effect of intensive care unit treatment , 2018, Acta physiologica.
[53] R. Morimoto,et al. Rethinking HSF1 in Stress, Development, and Organismal Health. , 2017, Trends in cell biology.
[54] T. B. Huber,et al. The Evolving Complexity of the Podocyte Cytoskeleton. , 2017, Journal of the American Society of Nephrology : JASN.
[55] Pitter F. Huesgen,et al. N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton. , 2017, Journal of the American Society of Nephrology : JASN.
[56] V. Timmerman,et al. Novel insights in the disease biology of mutant small heat shock proteins in neuromuscular diseases. , 2017, Brain : a journal of neurology.
[57] M. Rief,et al. Multiplexing molecular tension sensors reveals piconewton force gradient across talin-1 , 2017, Nature Methods.
[58] J. Höhfeld,et al. BAG3-mediated proteostasis at a glance , 2017, Journal of Cell Science.
[59] M. Huse. Mechanical forces in the immune system , 2017, Nature Reviews Immunology.
[60] Robyn M. Kaake,et al. A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress. , 2017, JCI insight.
[61] K. Endlich,et al. Stressed podocytes—mechanical forces, sensors, signaling and response , 2017, Pflügers Archiv - European Journal of Physiology.
[62] M. Sheetz,et al. Molecular stretching modulates mechanosensing pathways , 2017, Protein science : a publication of the Protein Society.
[63] I. Dikič. Proteasomal and Autophagic Degradation Systems. , 2017, Annual review of biochemistry.
[64] S. Novak,et al. Overview of the Muscle Cytoskeleton. , 2017, Comprehensive Physiology.
[65] A. Dinkova-Kostova,et al. Regulation of the mammalian heat shock factor 1 , 2017, The FEBS journal.
[66] R. Morimoto,et al. Shaping proteostasis at the cellular, tissue, and organismal level , 2017, The Journal of cell biology.
[67] T. Springer,et al. Integrin extension enables ultrasensitive regulation by cytoskeletal force , 2017, Proceedings of the National Academy of Sciences.
[68] Markus M. Rinschen,et al. YAP-mediated mechanotransduction determines the podocyte’s response to damage , 2017, Science Signaling.
[69] J. Landry,et al. Fine-tuning of actin dynamics by the HSPB8-BAG3 chaperone complex facilitates cytokinesis and contributes to its impact on cell division , 2017, Cell Stress and Chaperones.
[70] Sangkyun Cho,et al. Mechanosensing by the nucleus: From pathways to scaling relationships , 2017, The Journal of cell biology.
[71] J. Gestwicki,et al. BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins. , 2017, Journal of molecular biology.
[72] Lena Reimann,et al. Myofibrillar Z-discs Are a Protein Phosphorylation Hot Spot with Protein Kinase C (PKCα) Modulating Protein Dynamics* , 2016, Molecular & Cellular Proteomics.
[73] S. Tans,et al. Small heat shock proteins sequester misfolding proteins in near-native conformation for cellular protection and efficient refolding , 2016, Nature Communications.
[74] G. Remuzzi,et al. Podocyte–actin dynamics in health and disease , 2016, Nature Reviews Nephrology.
[75] A. Ciechanover,et al. The ubiquitin-proteasome system and autophagy: Coordinated and independent activities. , 2016, The international journal of biochemistry & cell biology.
[76] M. Mora,et al. DNAJB6 Myopathies: Focused Review on an Emerging and Expanding Group of Myopathies , 2016, Front. Mol. Biosci..
[77] Sanjay Kumar,et al. Actomyosin stress fiber mechanosensing in 2D and 3D , 2016, F1000Research.
[78] Markus M. Rinschen,et al. Quantitative deep mapping of the cultured podocyte proteome uncovers shifts in proteostatic mechanisms during differentiation. , 2016, American journal of physiology. Cell physiology.
[79] G. Leo,et al. A Surveillance Function of the HSPB8-BAG3-HSP70 Chaperone Complex Ensures Stress Granule Integrity and Dynamism. , 2016, Molecular cell.
[80] G. Balogh,et al. The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction , 2016, Science Translational Medicine.
[81] K. Murray,et al. Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling. , 2016, The American journal of pathology.
[82] D. Bourboulia,et al. Structural and functional basis of protein phosphatase 5 substrate specificity , 2016, Proceedings of the National Academy of Sciences.
[83] Jie Yan,et al. The mechanical response of talin , 2016, Nature Communications.
[84] David Balchin,et al. In vivo aspects of protein folding and quality control , 2016, Science.
[85] Dennis E. Discher,et al. SnapShot: Mechanosensing Matrix , 2016, Cell.
[86] Markus M. Rinschen,et al. A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes. , 2016, JCI insight.
[87] D. Surdez,et al. Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation , 2016, Oncotarget.
[88] P. Iglesias,et al. Mechanoaccumulative Elements of the Mammalian Actin Cytoskeleton , 2016, Current Biology.
[89] K. Burridge,et al. Mechanotransduction and nuclear function. , 2016, Current opinion in cell biology.
[90] C. Ballestrem,et al. Mechanosensitive components of integrin adhesions: Role of vinculin , 2016, Experimental cell research.
[91] N. Jones,et al. Nephrin Suppresses Hippo Signaling through the Adaptor Proteins Nck and WTIP* , 2016, The Journal of Biological Chemistry.
[92] R. Bryson-Richardson,et al. FLNC myofibrillar myopathy results from impaired autophagy and protein insufficiency. , 2016, Human molecular genetics.
[93] C. Cereda,et al. Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases , 2016, Scientific Reports.
[94] W. H. Goldmann,et al. Role of vinculin in cellular mechanotransduction , 2016, Cell biology international.
[95] F. Hartl,et al. Failure of RQC machinery causes protein aggregation and proteotoxic stress , 2016, Nature.
[96] D. Picard,et al. A Remodeled Hsp90 Molecular Chaperone Ensemble with the Novel Cochaperone Aarsd1 Is Required for Muscle Differentiation , 2016, Molecular and Cellular Biology.
[97] A. Philp,et al. Live strong and prosper: the importance of skeletal muscle strength for healthy ageing , 2016, Biogerontology.
[98] M. Mann,et al. Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA , 2016, Science.
[99] M. Gautel,et al. The sarcomeric cytoskeleton: from molecules to motion , 2016, Journal of Experimental Biology.
[100] Nolan J Hoffman,et al. Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates. , 2015, Cell metabolism.
[101] M. Rief,et al. Extracellular rigidity sensing by talin isoform–specific mechanical linkages , 2015, Nature Cell Biology.
[102] B. Reif,et al. The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client , 2015, Nature Structural &Molecular Biology.
[103] C. Bauvy,et al. The Pro-apoptotic STK38 Kinase Is a New Beclin1 Partner Positively Regulating Autophagy , 2015, Current Biology.
[104] W J Nelson,et al. The mechanotransduction machinery at work at adherens junctions. , 2015, Integrative biology : quantitative biosciences from nano to macro.
[105] J. Landry,et al. A Role for the Chaperone Complex BAG3-HSPB8 in Actin Dynamics, Spindle Orientation and Proper Chromosome Segregation during Mitosis , 2015, PLoS genetics.
[106] Adam Byron,et al. Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly , 2015, Nature Cell Biology.
[107] Frederick Sachs,et al. Mechanical dynamics in live cells and fluorescence-based force/tension sensors. , 2015, Biochimica et biophysica acta.
[108] A. Knicker,et al. High force development augments skeletal muscle signalling in resistance exercise modes equalized for time under tension , 2015, Pflügers Archiv - European Journal of Physiology.
[109] J. Southern,et al. BAG3 myofibrillar myopathy presenting with cardiomyopathy , 2015, Neuromuscular Disorders.
[110] U. Jakob,et al. Protein quality control under oxidative stress conditions. , 2015, Journal of molecular biology.
[111] C. Ugrinowitsch,et al. A Review of Resistance Training-Induced Changes in Skeletal Muscle Protein Synthesis and Their Contribution to Hypertrophy , 2015, Sports Medicine.
[112] W. Bloch,et al. Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle , 2015, Autophagy.
[113] K. Lemley,et al. A potential role for mechanical forces in the detachment of podocytes and the progression of CKD. , 2015, Journal of the American Society of Nephrology : JASN.
[114] Corey O. Brizzee,et al. BAG3 facilitates the clearance of endogenous tau in primary neurons , 2015, Neurobiology of Aging.
[115] G. Lienhard,et al. SPECHT - single-stage phosphopeptide enrichment and stable-isotope chemical tagging: quantitative phosphoproteomics of insulin action in muscle. , 2015, Journal of proteomics.
[116] E. Yusko,et al. Force is a signal that cells cannot ignore , 2014, Molecular biology of the cell.
[117] W. Pokrzywa,et al. Challenging muscle homeostasis uncovers novel chaperone interactions in Caenorhabditis elegans , 2014, Front. Mol. Biosci..
[118] Niels Volkmann,et al. The minimal cadherin-catenin complex binds to actin filaments under force , 2014, Science.
[119] Michael J. Randles,et al. The Importance of Podocyte Adhesion for a Healthy Glomerulus , 2014, Front. Endocrinol..
[120] R. Bryson-Richardson,et al. Zebrafish models of BAG3 myofibrillar myopathy suggest a toxic gain of function leading to BAG3 insufficiency , 2014, Acta Neuropathologica.
[121] Marius Sudol,et al. The Hippo signal transduction network in skeletal and cardiac muscle , 2014, Science Signaling.
[122] Jie Yan,et al. Force-dependent conformational switch of α-catenin controls vinculin binding , 2014, Nature Communications.
[123] J. Hartwig,et al. Documentation and Localization of Force-mediated Filamin A Domain Perturbations in Moving Cells , 2014, Nature Communications.
[124] Markus M. Rinschen,et al. Phosphoproteomic analysis reveals regulatory mechanisms at the kidney filtration barrier. , 2014, Journal of the American Society of Nephrology : JASN.
[125] Laura A. New,et al. Advances in slit diaphragm signaling , 2014, Current opinion in nephrology and hypertension.
[126] Bonnie Berger,et al. A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways , 2014, Cell.
[127] D. Pilgrim,et al. Unc45b is essential for early myofibrillogenesis and costamere formation in zebrafish. , 2014, Developmental biology.
[128] Jie Yan,et al. Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation , 2014, Scientific Reports.
[129] Matthias Rief,et al. Force-dependent isomerization kinetics of a highly conserved proline switch modulates the mechanosensing region of filamin , 2014, Proceedings of the National Academy of Sciences.
[130] B. Schermer,et al. Breaking the chain at the membrane: paraoxonase 2 counteracts lipid peroxidation at the plasma membrane , 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[131] Wolfgang A. Linke,et al. Gigantic Business: Titin Properties and Function Through Thick and Thin , 2014, Circulation research.
[132] A. Nagy,et al. Low-force transitions in single titin molecules reflect a memory of contractile history , 2014, Journal of Cell Science.
[133] L. Cantley,et al. Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome , 2014, Cell.
[134] T. Hornberger,et al. The mechanical activation of mTOR signaling: an emerging role for late endosome/lysosomal targeting , 2014, Journal of Muscle Research and Cell Motility.
[135] W. Linke,et al. Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins , 2014, The Journal of cell biology.
[136] L. Sistonen,et al. HSF1 at a glance , 2014, Journal of Cell Science.
[137] J. Lammerding,et al. Nuclear Mechanics and Mechanotransduction in Health and Disease , 2013, Current Biology.
[138] E. Zuiderweg,et al. The Molecular Chaperone Hsp70 Activates Protein Phosphatase 5 (PP5) by Binding the Tetratricopeptide Repeat (TPR) Domain* , 2013, The Journal of Biological Chemistry.
[139] C. Betz,et al. Where is mTOR and what is it doing there? , 2013, The Journal of cell biology.
[140] Pablo A Iglesias,et al. Molecular Mechanisms of Cellular Mechanosensing , 2013, Nature materials.
[141] Donald E Ingber,et al. Mechanobiology and developmental control. , 2013, Annual review of cell and developmental biology.
[142] F. Grahammer,et al. The podocyte slit diaphragm—from a thin grey line to a complex signalling hub , 2013, Nature Reviews Nephrology.
[143] Johannes Buchner,et al. Regulated structural transitions unleash the chaperone activity of αB-crystallin , 2013, Proceedings of the National Academy of Sciences.
[144] W. H. Goldmann,et al. CAS directly interacts with vinculin to control mechanosensing and focal adhesion dynamics , 2013, Cellular and Molecular Life Sciences.
[145] Y. Li,et al. Mechanical stretch changes coronary artery fibroblasts function by upregulating HSF1 protein expression. , 2013, International journal of biological macromolecules.
[146] W. Pokrzywa,et al. Chaperoning myosin assembly in muscle formation and aging , 2013, Worm.
[147] Yujin E. Kim,et al. Molecular chaperone functions in protein folding and proteostasis. , 2013, Annual review of biochemistry.
[148] T. Benzing,et al. The role of the podocyte in albumin filtration , 2013, Nature Reviews Nephrology.
[149] R. Fässler,et al. Mechanosensitivity and compositional dynamics of cell–matrix adhesions , 2013, EMBO reports.
[150] W. Rottbauer,et al. Lysine methyltransferase Smyd2 regulates Hsp90-mediated protection of the sarcomeric titin springs and cardiac function. , 2013, Biochimica et biophysica acta.
[151] A. Sonnenberg,et al. Cell–matrix adhesion of podocytes in physiology and disease , 2013, Nature Reviews Nephrology.
[152] P. Saftig,et al. Cellular Mechanotransduction Relies on Tension-Induced and Chaperone-Assisted Autophagy , 2013, Current Biology.
[153] K. Guan,et al. The Hippo pathway: regulators and regulations. , 2013, Genes & development.
[154] J. Lippincott-Schwartz,et al. NBR1 acts as an autophagy receptor for peroxisomes , 2013, Journal of Cell Science.
[155] J. Zierath,et al. Exercise metabolism and the molecular regulation of skeletal muscle adaptation. , 2013, Cell metabolism.
[156] G. Dreissen,et al. The constant beat: cardiomyocytes adapt their forces by equal contraction upon environmental stiffening , 2013, Biology Open.
[157] N. Hogg,et al. T lymphocytes orient against the direction of fluid flow during LFA-1-mediated migration. , 2013, Biophysical journal.
[158] T. Clausen,et al. The Myosin Chaperone UNC-45 Is Organized in Tandem Modules to Support Myofilament Formation in C. elegans , 2013, Cell.
[159] Stephan Huveneers,et al. Mechanosensitive systems at the cadherin–F-actin interface , 2013, Journal of Cell Science.
[160] Nobuyuki Itoh,et al. Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine , 2012, Nature Medicine.
[161] Matthias Rief,et al. Dynamic force sensing of filamin revealed in single-molecule experiments , 2012, Proceedings of the National Academy of Sciences.
[162] A. Cuervo,et al. Chaperone-mediated autophagy: a unique way to enter the lysosome world. , 2012, Trends in cell biology.
[163] K. Endlich,et al. The challenge and response of podocytes to glomerular hypertension. , 2012, Seminars in nephrology.
[164] R. Liddington,et al. αE-catenin is an autoinhibited molecule that coactivates vinculin , 2012, Proceedings of the National Academy of Sciences.
[165] A. Oberhauser,et al. Tracking UNC-45 chaperone-myosin interaction with a titin mechanical reporter. , 2012, Biophysical journal.
[166] A. Kakita,et al. Autophagic adapter protein NBR1 is localized in Lewy bodies and glial cytoplasmic inclusions and is involved in aggregate formation in α-synucleinopathy , 2012, Acta Neuropathologica.
[167] J. Pollard,et al. A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells , 2012, Science.
[168] D. Sabatini,et al. mTOR Signaling in Growth Control and Disease , 2012, Cell.
[169] R. Schrier,et al. Glomerular hyperfiltration: definitions, mechanisms and clinical implications , 2012, Nature Reviews Nephrology.
[170] N. Kirchgessner,et al. Cyclic stretch induces reorientation of cells in a Src family kinase- and p130Cas-dependent manner. , 2012, European journal of cell biology.
[171] M. Hauser,et al. Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy , 2012, Nature Genetics.
[172] Herman I. May,et al. Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis , 2012, Nature.
[173] Wolfgang Rottbauer,et al. Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization. , 2012, Genes & development.
[174] M. Looso,et al. On Marathons and Sprints: An Integrated Quantitative Proteomics and Transcriptomics Analysis of Differences Between Slow and Fast Muscle Fibers* , 2011, Molecular & Cellular Proteomics.
[175] P. Garg,et al. Nephrin Regulates Lamellipodia Formation by Assembling a Protein Complex That Includes Ship2, Filamin and Lamellipodin , 2011, PloS one.
[176] T. Arimura,et al. Dilated cardiomyopathy‐associated BAG3 mutations impair Z‐disc assembly and enhance sensitivity to apoptosis in cardiomyocytes , 2011, Human mutation.
[177] K. Wilson,et al. The nucleoskeleton as a genome-associated dynamic 'network of networks' , 2011, Nature Reviews Molecular Cell Biology.
[178] K. Richter,et al. Downregulation of the Hsp90 System Causes Defects in Muscle Cells of Caenorhabditis Elegans , 2011, PloS one.
[179] Wei Guo,et al. Differential turnover of myosin chaperone UNC-45A isoforms increases in metastatic human breast cancer. , 2011, Journal of molecular biology.
[180] D. Weitz,et al. Mechanical strain in actin networks regulates FilGAP and integrin binding to Filamin A , 2011, Nature.
[181] K. Ocorr,et al. The UNC-45 Chaperone Is Critical for Establishing Myosin-Based Myofibrillar Organization and Cardiac Contractility in the Drosophila Heart Model , 2011, PloS one.
[182] Andreas Bracher,et al. Molecular chaperones in protein folding and proteostasis , 2011, Nature.
[183] Brenton D. Hoffman,et al. Dynamic molecular processes mediate cellular mechanotransduction , 2011, Nature.
[184] K. Fischbach,et al. The BAR Domain Protein PICK1 Regulates Cell Recognition and Morphogenesis by Interacting with Neph Proteins , 2011, Molecular and Cellular Biology.
[185] Nicola Elvassore,et al. Role of YAP/TAZ in mechanotransduction , 2011, Nature.
[186] Matthew J. Paszek,et al. Balancing forces: architectural control of mechanotransduction , 2011, Nature Reviews Molecular Cell Biology.
[187] K. Nair,et al. Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: underlying mechanisms , 2011, The Journal of physiology.
[188] D. Selcen. Myofibrillar myopathies , 2011, Neuromuscular Disorders.
[189] J. Hartwig,et al. The filamins , 2011, Cell adhesion & migration.
[190] U. Wolfrum,et al. BAG3 mediates chaperone‐based aggresome‐targeting and selective autophagy of misfolded proteins , 2011, EMBO reports.
[191] J. Buchner,et al. The heat shock response: life on the verge of death. , 2010, Molecular cell.
[192] B. Bukau,et al. Protein quality control in the cytosol and the endoplasmic reticulum: brothers in arms. , 2010, Molecular cell.
[193] Peter M. Douglas,et al. Protein homeostasis and aging in neurodegeneration , 2010, The Journal of cell biology.
[194] C. Bendotti,et al. The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS). , 2010, Human molecular genetics.
[195] S. Thrun,et al. Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture , 2010, Science.
[196] Pere Roca-Cusachs,et al. Stretchy proteins on stretchy substrates: the important elements of integrin-mediated rigidity sensing. , 2010, Developmental cell.
[197] S. Yonemura,et al. α-Catenin as a tension transducer that induces adherens junction development , 2010, Nature Cell Biology.
[198] M. Sandri. Autophagy in skeletal muscle , 2010, FEBS letters.
[199] Junjie Hou,et al. Phosphoproteome analysis of rat L6 myotubes using reversed-phase C18 prefractionation and titanium dioxide enrichment. , 2010, Journal of proteome research.
[200] M. Hoch,et al. Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance , 2010, Current Biology.
[201] F. Ding,et al. N‐terminal strands of filamin Ig domains act as a conformational switch under biological forces , 2010, Proteins.
[202] D. Metzger,et al. Autophagy is required to maintain muscle mass. , 2009, Cell metabolism.
[203] C. Flynn,et al. In vivo phosphoproteome of human skeletal muscle revealed by phosphopeptide enrichment and HPLC-ESI-MS/MS. , 2009, Journal of proteome research.
[204] J. Cross,et al. Translational signaling responses preceding resistance training-mediated myofiber hypertrophy in young and old humans. , 2009, Journal of applied physiology.
[205] Roger D. Kamm,et al. Biomechanics: Cell Research and Applications for the Next Decade , 2009, Annals of Biomedical Engineering.
[206] M. Komatsu,et al. A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. , 2009, Molecular cell.
[207] F. Hartl,et al. Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3 , 2009, The EMBO journal.
[208] Michael P. Sheetz,et al. Stretching Single Talin Rod Molecules Activates Vinculin Binding , 2009, Science.
[209] V. Hill,et al. Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease. , 2008, Human molecular genetics.
[210] F. Muntoni,et al. Mutation in BAG3 causes severe dominant childhood muscular dystrophy , 2008, Annals of neurology.
[211] Klaus Ley,et al. Cells on the run: shear-regulated integrin activation in leukocyte rolling and arrest on endothelial cells. , 2008, Current opinion in cell biology.
[212] T. Hoppe,et al. Protein quality control gets muscle into shape. , 2008, Trends in cell biology.
[213] M. Turco,et al. bag3 gene expression is regulated by heat shock factor 1 , 2008, Journal of cellular physiology.
[214] U. Strähle,et al. Shuttling of the chaperones Unc45b and Hsp90a between the A band and the Z line of the myofibril , 2008, The Journal of cell biology.
[215] J. Landry,et al. HspB8 Chaperone Activity toward Poly(Q)-containing Proteins Depends on Its Association with Bag3, a Stimulator of Macroautophagy* , 2008, Journal of Biological Chemistry.
[216] Yongwang Zhong,et al. Heat-shock protein 90α1 is required for organized myofibril assembly in skeletal muscles of zebrafish embryos , 2008, Proceedings of the National Academy of Sciences.
[217] I. Shih,et al. Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility. , 2007, The American journal of pathology.
[218] M. Cybulsky,et al. Getting to the site of inflammation: the leukocyte adhesion cascade updated , 2007, Nature Reviews Immunology.
[219] Olli T Pentikäinen,et al. Structure of three tandem filamin domains reveals auto-inhibition of ligand binding , 2007, The EMBO journal.
[220] D. Speicher,et al. Forced Unfolding of Proteins Within Cells , 2007, Science.
[221] A. Cumano,et al. Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior , 2007, Science.
[222] R. Geisler,et al. The UCS factor Steif/Unc-45b interacts with the heat shock protein Hsp90a during myofibrillogenesis. , 2007, Developmental biology.
[223] R. Geha,et al. Transcellular diapedesis is initiated by invasive podosomes. , 2007, Immunity.
[224] B. Schermer,et al. Podocin Organizes Ion Channel-Lipid Supercomplexes: Implications for Mechanosensation at the Slit Diaphragm , 2007, Nephron Experimental Nephrology.
[225] Hanns Lochmüller,et al. The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy , 2007, Nature Cell Biology.
[226] D. Pilgrim,et al. The myosin co-chaperone UNC-45 is required for skeletal and cardiac muscle function in zebrafish. , 2007, Developmental biology.
[227] Michael P. Sheetz,et al. Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130Cas , 2006, Cell.
[228] M. Chalfie,et al. Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels , 2006, Proceedings of the National Academy of Sciences.
[229] A. Russell,et al. Akt signalling through GSK‐3β, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy , 2006, The Journal of physiology.
[230] John Calvin Reed,et al. BAG3 deficiency results in fulminant myopathy and early lethality. , 2006, The American journal of pathology.
[231] S. Sen,et al. Matrix Elasticity Directs Stem Cell Lineage Specification , 2006, Cell.
[232] H. Katus,et al. The sarcomeric Z-disc: a nodal point in signalling and disease , 2006, Journal of Molecular Medicine.
[233] Anthony Shield,et al. Early signaling responses to divergent exercise stimuli in skeletal muscle from well‐trained humans , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[234] J. Small,et al. The comings and goings of actin: coupling protrusion and retraction in cell motility. , 2005, Current opinion in cell biology.
[235] Thomas Sejersen,et al. The Kinase Domain of Titin Controls Muscle Gene Expression and Protein Turnover , 2005, Science.
[236] Thomas Benzing,et al. The slit diaphragm: a signaling platform to regulate podocyte function , 2005, Current opinion in nephrology and hypertension.
[237] Waldemar Kolanus,et al. Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines , 2005, Nature Immunology.
[238] T. Hoppe,et al. Regulation of the Myosin-Directed Chaperone UNC-45 by a Novel E3/E4-Multiubiquitylation Complex in C. elegans , 2004, Cell.
[239] Thomas Benzing,et al. Signaling at the slit diaphragm. , 2004, Journal of the American Society of Nephrology : JASN.
[240] W. Pyle,et al. At the crossroads of myocardial signaling: the role of Z-discs in intracellular signaling and cardiac function. , 2004, Circulation research.
[241] Bernhard Schermer,et al. Nephrin and CD2AP Associate with Phosphoinositide 3-OH Kinase and Stimulate AKT-Dependent Signaling , 2003, Molecular and Cellular Biology.
[242] Ashok Kumar,et al. Distinct Signaling Pathways Are Activated in Response to Mechanical Stress Applied Axially and Transversely to Skeletal Muscle Fibers* , 2002, The Journal of Biological Chemistry.
[243] J. Barral,et al. Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions , 2002, Journal of Cell Science.
[244] M. Nilges,et al. Pathways and intermediates in forced unfolding of spectrin repeats. , 2002, Structure.
[245] Mark J. Miller,et al. Two-Photon Imaging of Lymphocyte Motility and Antigen Response in Intact Lymph Node , 2002, Science.
[246] F. Hartl,et al. Role of the Myosin Assembly Protein UNC-45 as a Molecular Chaperone for Myosin , 2002, Science.
[247] U. Proske,et al. Muscle damage from eccentric exercise: mechanism, mechanical signs, adaptation and clinical applications , 2001, The Journal of physiology.
[248] C. Rommel,et al. Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways , 2001, Nature Cell Biology.
[249] G. Yancopoulos,et al. Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo , 2001, Nature Cell Biology.
[250] R. Lüllmann-Rauch,et al. Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice , 2000, Nature.
[251] M. Rief,et al. Single molecule force spectroscopy of spectrin repeats: low unfolding forces in helix bundles. , 1999, Journal of molecular biology.
[252] J. Barral,et al. Unc-45 Mutations in Caenorhabditis elegans Implicate a CRO1/She4p-like Domain in Myosin Assembly , 1998, The Journal of cell biology.
[253] J. Spudich,et al. Single myosin molecule mechanics: piconewton forces and nanometre steps , 1994, Nature.
[254] R. Waterston,et al. The unc-45 gene of Caenorhabditis elegans is an essential muscle-affecting gene with maternal expression. , 1990, Genetics.
[255] H. Kimpton,et al. The Kidney in Health and Disease , 1935, The Indian Medical Gazette.
[256] J. Buchner,et al. Functional principles and regulation of molecular chaperones. , 2019, Advances in protein chemistry and structural biology.
[257] S. Züchner,et al. Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks , 2018, Nature Communications.
[258] B. Fleischmann,et al. The cochaperone BAG3 coordinates protein synthesis and autophagy under mechanical strain through spatial regulation of mTORC1. , 2017, Biochimica et biophysica acta. Molecular cell research.
[259] C. Behl,et al. Ubiquitin-Dependent And Independent Signals In Selective Autophagy. , 2016, Trends in cell biology.
[260] V. D’Agati,et al. Podocyte-Specific Deletion of Yes-Associated Protein Causes FSGS and Progressive Renal Failure. , 2016, Journal of the American Society of Nephrology : JASN.
[261] C. Goodman. The role of mTORC1 in regulating protein synthesis and skeletal muscle mass in response to various mechanical stimuli. , 2014, Reviews of physiology, biochemistry and pharmacology.
[262] Jonathan A. Coles,et al. Two-photon imaging , 2009 .
[263] Michael Loran Dustin,et al. Force as a facilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cells. , 2007, Immunity.
[264] Amos Etzioni. Leukocyte adhesion deficiencies: molecular basis, clinical findings, and therapeutic options. , 2007, Advances in experimental medicine and biology.
[265] Frank E. Marino,et al. Designing Resistance Training Programmes to Enhance Muscular Fitness , 2005, Sports medicine.
[266] Kenneth C Holmes,et al. The molecular mechanism of muscle contraction. , 2005, Advances in protein chemistry.
[267] A. Mehta,et al. Single myosin molecule mechanics , 1999 .