Secondary prevention and estimation of fracture risk.

The key questions addressed in this chapter are: • How can individual risk of fracture be best estimated? • What is the best system to prevent a further fracture? • How to implement systems for preventing further fractures? Absolute fracture risk calculators (FRCs) provide a means to estimate an individual's future fracture risk. FRCs are widely available and provide clinicians and patients a platform to discuss the need for intervention to prevent fragility fractures. Despite availability of effective osteoporosis medicines for almost two decades, most patients presenting with new fragility fractures do not receive secondary preventive care. The Fracture Liaison Service (FLS) model has been shown in a number of countries to eliminate the care gap in a clinically and cost-effective manner. Leading international and national organisations have developed comprehensive resources and/or national strategy documents to provide guidance on implementation of FLS in local, regional and national health-care systems.

[1]  C. Cooper,et al.  Capture the Fracture: a Best Practice Framework and global campaign to break the fragility fracture cycle , 2013, Osteoporosis International.

[2]  J. Reginster,et al.  Efficacy and tolerability of intravenous ibandronate injections in postmenopausal osteoporosis: 2-year results from the DIVA study. , 2008, The Journal of rheumatology.

[3]  D. Milne,et al.  Incidental vertebral fractures on computed tomography. , 2012, The New Zealand medical journal.

[4]  P. Geusens,et al.  Assessment of Individual Fracture Risk: FRAX and Beyond , 2010, Current osteoporosis reports.

[5]  P. Mitchell Fracture Liaison Services: the UK experience , 2011, Osteoporosis International.

[6]  E. Barrett-Connor,et al.  Treatment with alendronate prevents fractures in women at highest risk: results from the Fracture Intervention Trial. , 1997, Archives of internal medicine.

[7]  E. M. Lewiecki,et al.  Clinician’s Guide to Prevention and Treatment of Osteoporosis , 2014, Osteoporosis International.

[8]  P Geusens,et al.  Effect of risedronate on the risk of hip fracture in elderly women. Hip Intervention Program Study Group. , 2001, The New England journal of medicine.

[9]  D. Beaton,et al.  Factors influencing the pharmacological management of osteoporosis after fragility fracture: results from the Ontario Osteoporosis Strategy’s fracture clinic screening program , 2013, Osteoporosis International.

[10]  J. A. Kanis,et al.  European guidance for the diagnosis and management of osteoporosis in postmenopausal women , 2013, Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.

[11]  C. Cooper,et al.  Epidemiology of fractures in England and Wales. , 2001, Bone.

[12]  C. Mitchell,et al.  Closing the osteoporosis management gap in primary care: a secondary prevention of fracture programme* , 2005, Current medical research and opinion.

[13]  J. Adachi,et al.  Combined Vertebral Fracture Assessment and Bone Mineral Density Measurement: A Patient-friendly New Tool with an Important Impact on the Canadian Risk Fracture Classification , 2010, Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes.

[14]  S. Beard,et al.  Fracture liaison services for the evaluation and management of patients with osteoporotic fracture: a cost-effectiveness evaluation based on data collected over 8 years of service provision , 2011, Osteoporosis International.

[15]  David A Hanley,et al.  2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary , 2010, Canadian Medical Association Journal.

[16]  J. Cramer,et al.  Non-compliance: the Achilles' heel of anti-fracture efficacy , 2007, Osteoporosis International.

[17]  T. Abbott,et al.  Patients with Prior Fractures Have an Increased Risk of Future Fractures: A Summary of the Literature and Statistical Synthesis , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[18]  L. Peng,et al.  Unrecognized vertebral body fractures (VBFs) in chest radiographic reports in Taiwan: a hospital-based study. , 2012, Archives of gerontology and geriatrics.

[19]  R. Cumming,et al.  Osteoporotic fracture: missed opportunity for intervention , 2003, Osteoporosis International.

[20]  J. Reginster,et al.  Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. , 2001, The New England journal of medicine.

[21]  S. Boonen,et al.  Coordinator-based systems for secondary prevention in fragility fracture patients , 2011, Osteoporosis International.

[22]  Jacques P. Brown,et al.  Two-year efficacy and tolerability of risedronate once a week for the treatment of women with postmenopausal osteoporosis , 2004, Current medical research and opinion.

[23]  I. Pillay,et al.  Fracture liaison service in a non-regional orthopaedic clinic--a cost-effective service. , 2012, Irish medical journal.

[24]  H. Genant,et al.  Underdiagnosis of Vertebral Fractures Is a Worldwide Problem: The IMPACT Study , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[25]  I. Reid,et al.  Effect of osteoporosis treatment on mortality: a meta-analysis. , 2010, The Journal of clinical endocrinology and metabolism.

[26]  Carol Coupland,et al.  Derivation and validation of updated QFracture algorithm to predict risk of osteoporotic fracture in primary care in the United Kingdom: prospective open cohort study , 2012, BMJ : British Medical Journal.

[27]  Beate Sander,et al.  A coordinator program in post-fracture osteoporosis management improves outcomes and saves costs. , 2008, The Journal of bone and joint surgery. American volume.

[28]  J. Reginster,et al.  Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study. , 2005, The Journal of clinical endocrinology and metabolism.

[29]  David A Hanley,et al.  Independent external validation of nomograms for predicting risk of low-trauma fracture and hip fracture , 2011, Canadian Medical Association Journal.

[30]  S. Cummings,et al.  Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures , 1996, The Lancet.

[31]  J. Dungan Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis , 2010 .

[32]  Mark J Bolland,et al.  Evaluation of the FRAX and Garvan fracture risk calculators in older women , 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[33]  C. Cooper,et al.  Breaking the fragility fracture cycle , 2011, Osteoporosis International.

[34]  C C Glüer,et al.  Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators. , 1999, JAMA.

[35]  H. Genant,et al.  Enhanced prediction of fracture risk combining vertebral fracture status and BMD , 2007, Osteoporosis International.

[36]  B. Riggs,et al.  Epidemiology of fractures of the proximal femur in Rochester, Minnesota. , 1980, Clinical orthopaedics and related research.

[37]  R. Dell Fracture prevention in Kaiser Permanente Southern California , 2011, Osteoporosis International.

[38]  Kim Brixen,et al.  Risk assessment tools to identify women with increased risk of osteoporotic fracture: Complexity or simplicity? A systematic review , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[39]  E. Ollagnier,et al.  Management of osteoporosis in fracture liaison service associated with long-term adherence to treatment , 2011, Osteoporosis International.

[40]  L. Giangregorio,et al.  Fragility fractures and the osteoporosis care gap: an international phenomenon. , 2006, Seminars in arthritis and rheumatism.

[41]  J. Eisman,et al.  Models of care for the secondary prevention of osteoporotic fractures: a systematic review and meta-analysis , 2013, Osteoporosis International.

[42]  M. Cooper,et al.  Cost-effectiveness of the Concord Minimal Trauma Fracture Liaison service, a prospective, controlled fracture prevention study , 2011, Osteoporosis International.

[43]  M. van der Elst,et al.  Implementation of osteoporosis guidelines: a survey of five large fracture liaison services in the Netherlands , 2010, Osteoporosis International.

[44]  R. Rizzoli Two‐Year Results of Once‐Weekly Administration of Alendronate 70 mg for the Treatment of Postmenopausal Osteoporosis , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[45]  B. Edwards,et al.  Prior Fractures are Common in Patients with Subsequent Hip Fractures , 2007, Clinical orthopaedics and related research.

[46]  R. Dell,et al.  Osteoporosis disease management: the role of the orthopaedic surgeon. , 2008, The Journal of bone and joint surgery. American volume.

[47]  M. Eccles,et al.  A systematic review of the effectiveness of interventions to improve post-fracture investigation and management of patients at risk of osteoporosis , 2010, Implementation science : IS.

[48]  S. Berney,et al.  Once-Yearly Zoledronic Acid for Treatment of Postmenopausal Osteoporosis , 2008 .

[49]  J. Eisman,et al.  Incidence of Hip and Other Osteoporotic Fractures in Elderly Men and Women: Dubbo Osteoporosis Epidemiology Study , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[50]  María,et al.  Guías 2012 para el diagnóstico, la prevención y el tratamiento de la osteoporosis , 2013 .

[51]  C. Cooper,et al.  Guidelines for the diagnosis and management of osteoporosis in postmenopausal women and men from the age of 50 years in the UK. , 2009, Maturitas.

[52]  O Johnell,et al.  A meta-analysis of previous fracture and subsequent fracture risk. , 2004, Bone.

[53]  L. Munuera,et al.  Interventions to improve inpatient osteoporosis management following first osteoporotic fracture: the PREVENT project , 2009, Archives of Orthopaedic and Trauma Surgery.

[54]  R. Cumming,et al.  Oral bisphosphonates are associated with reduced mortality in frail older people: a prospective five-year study , 2011, Osteoporosis International.

[55]  E. Lespessailles,et al.  2012 update of French guidelines for the pharmacological treatment of postmenopausal osteoporosis. , 2012, Joint, bone, spine : revue du rhumatisme.

[56]  D. Beaton,et al.  Systematic review on interventions to improve osteoporosis investigation and treatment in fragility fracture patients , 2011, Osteoporosis International.

[57]  F. Callachand,et al.  An evaluation of an enhanced fracture liaison service as the optimal model for secondary prevention of osteoporosis , 2011, JRSM short reports.

[58]  S. Boonen,et al.  Efficacy and safety of risedronate 150-mg once a month in the treatment of postmenopausal osteoporosis: 2-year data , 2012, Osteoporosis International.

[59]  P. Hoffmeyer,et al.  An Osteoporosis Clinical Pathway for the Medical Management of Patients with Low-Trauma Fracture , 2002, Osteoporosis International.

[60]  S. Majumdar,et al.  Oral bisphosphonates are associated with reduced mortality after hip fracture , 2011, Osteoporosis International.

[61]  L. Jeys,et al.  Are osteoporotic fractures being adequately investigated?: A questionnaire of GP & orthopaedic surgeons , 2006, BMC family practice.

[62]  M. Drezner,et al.  Efficacy and tolerability of once-monthly oral ibandronate in postmenopausal osteoporosis: 2 year results from the MOBILE study , 2005, Annals of the rheumatic diseases.

[63]  S. Silverman,et al.  Making the first fracture the last fracture: ASBMR task force report on secondary fracture prevention , 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[64]  B. Clarke,et al.  Diagnosis, screening, prevention, and treatment of osteoporosis. , 2006, Mayo Clinic proceedings.

[65]  J. Eisman,et al.  Individualized fracture risk assessment: progresses and challenges , 2013, Current opinion in rheumatology.

[66]  S. Gallacher,et al.  The fracture liaison service: success of a program for the evaluation and management of patients with osteoporotic fracture , 2003, Osteoporosis International.

[67]  M. Seibel,et al.  Targeted intervention reduces refracture rates in patients with incident non-vertebral osteoporotic fractures: a 4-year prospective controlled study , 2011, Osteoporosis International.

[68]  L. Lix,et al.  Comparison between various fracture risk assessment tools , 2013, Osteoporosis International.

[69]  S. Tan,et al.  Secondary prevention of osteoporotic fractures—an “OPTIMAL” model of care from Singapore , 2013, Osteoporosis International.

[70]  D. Beaton,et al.  Practice patterns in the diagnosis and treatment of osteoporosis after a fragility fracture: a systematic review , 2004, Osteoporosis International.

[71]  O. Johnell,et al.  FRAX™ and the assessment of fracture probability in men and women from the UK , 2008, Osteoporosis International.

[72]  S. Boonen,et al.  Zoledronic acid and clinical fractures and mortality after hip fracture. , 2007, The New England journal of medicine.

[73]  J. Eisman,et al.  Osteoporosis medication and reduced mortality risk in elderly women and men. , 2011, The Journal of clinical endocrinology and metabolism.

[74]  D. Beaton,et al.  Effective initiation of osteoporosis diagnosis and treatment for patients with a fragility fracture in an orthopaedic environment. , 2006, The Journal of bone and joint surgery. American volume.

[75]  D. Torgerson,et al.  Hormone replacement therapy and prevention of nonvertebral fractures: a meta-analysis of randomized trials. , 2001, JAMA.

[76]  Carol Coupland,et al.  Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFractureScores , 2009, BMJ : British Medical Journal.

[77]  S. Gehlbach,et al.  Recognition of Vertebral Fracture in a Clinical Setting , 2000, Osteoporosis International.

[78]  A. Negri,et al.  [Guidelines for the diagnosis, prevention and treatment of osteoporosis, 2012]. , 2013, Medicina.