Methodologies to examine the importance of host factors in bioavailability of metals.

Bioavailability provides a link between intrinsic toxicity and the ability to produce that toxic effect in an organism. Biomonitoring tools are essential to assess the health of ecosystems and their component parts, including humans. While field and laboratory data are available, two critical issues to our understanding of bioavailability are often missing: 1) knowing the relationship between dose and tissue concentrations, and 2) species extrapolations. Understanding of high to low dose extrapolation is also critical. Methods to understand the importance of host factors in bioavailability of metals must assess gender, age, nutritional status, individual variability, temporal changes, and critical habitat effects. Methods to examine these variables include correlational, observational, experimental, epidemiological, and modeling studies, or a combination of these. Data gaps include developing more representative studies of human and animal populations, better analytical tools for rapid determination of metal content in the field, improved analytical characterization of metal bioavailability, and concurrent studies of different metals.

[1]  G. Heinz.  Methylmercury: second-generation reproductive and behavioral effects on mallard ducks , 1976 .

[2]  P. Bourdeau,et al.  Methods to Assess the Effects of Chemicals on Ecosystems. , 1996 .

[3]  Guillermo Marshall,et al.  Lung Cancer and Arsenic Concentrations in Drinking Water in Chile , 2000, Epidemiology.

[4]  F. Díaz-Barriga,et al.  Arsenic-cadmium interaction in rats: toxic effects in the heart and tissue metal shifts. , 1991, Toxicology.

[5]  B. Goldstein,et al.  Use of longitudinal analysis of peripheral blood counts to validate historical reconstructions of benzene exposure. , 1989, Environmental health perspectives.

[6]  P. Goering,et al.  Metallothionein and other cadmium-binding proteins: recent developments. , 1990, Chemical research in toxicology.

[7]  J. S. Quinn.  The Black Skimmer: Social Dynamics of a Colonial Species, Joanna Burger, Michael Gochfeld. Columbia University Press, New York (1990), xiv, +355. Price $45·00 , 1991 .

[8]  E. McCabe.  Age and sensitivity to lead toxicity: a review. , 1979, Environmental health perspectives.

[9]  M. Ikeda,et al.  Correlation between urine and blood concentrations, and dietary intake of cadmium and lead among women in the general population of Japan , 2000, International archives of occupational and environmental health.

[10]  A. Todd,et al.  Maternal bone lead contribution to blood lead during and after pregnancy. , 2000, Environmental research.

[11]  H. Mason.  A biokinetic model for lead metabolism with a view to its extension to pregnancy and lactation; (1). Further validation of the original model for non-pregnant adults. , 2000, The Science of the total environment.

[12]  M. Patriarca,et al.  Environmental exposure to metals of newborns, infants and young children , 2000 .

[13]  J. J. Hickey,et al.  Oological Data on Egg and Breeding Characteristics of Brown Pelicans , 1970 .

[14]  R. A. Rubino,et al.  Role of Airborne Lead in Increased Body Burden of Lead in Hartford Children* , 1974, Environmental health perspectives.

[15]  D. Welsh,et al.  Nest success, cause-specific nest failure, and hatchability of aquatic birds at selenium-contaminated Kesterson Reservoir and a reference site , 1989 .

[16]  F. Díaz-Barriga,et al.  Arsenic-cadmium interaction in rats. , 1990, Toxicology.

[17]  I. Romieu,et al.  Blood lead levels and calcium intake in Mexico City children under five years of age , 2000, International journal of environmental health research.

[18]  T. Colborn,et al.  Chemically-induced alterations in sexual and functional development : the wildlife/human connection , 1992 .

[19]  T. Y. Toribara.  Analysis of single hair by XRF discloses mercury intake , 2001, Human & experimental toxicology.

[20]  J. Lincer.  DDE-Induced Eggshell-Thinning in the American Kestrel: A Comparison of the Field Situation and Laboratory Results , 1975 .

[21]  L. Sileo,et al.  PAINT CHIP POISONING OF LAYSAN ALBATROSS AT MIDWAY ATOLL , 1987, Journal of wildlife diseases.

[22]  C. S. Boring,et al.  Mercury and selenium in fish from the Savannah river: species, trophic level, and locational differences. , 2001, Environmental research.

[23]  H. Roels,et al.  Placental transfer of lead, mercury, cadmium, and carbon monoxide in women. I. Comparison of the frequency distributions of the biological indices in maternal and umbilical cord blood. , 1978, Environmental research.

[24]  G. Killough,et al.  Evaluation of Atmospheric Transport Models for Use in Phase II of the Historical Public Exposures Studies at the Rocky Flats Plant , 1999, Risk analysis : an official publication of the Society for Risk Analysis.

[25]  R. Haque,et al.  Environmental Dynamics of Pesticides , 1975 .

[26]  M. Berglund,et al.  Bioavailability of cadmium from shellfish and mixed diet in women. , 1996, Toxicology and applied pharmacology.

[27]  D Mergler,et al.  Sequential analysis of hair mercury levels in relation to fish diet of an Amazonian population, Brazil. , 2001, The Science of the total environment.

[28]  D. Peakall.  Animal biomarkers as pollution indicators , 1992 .

[29]  H. Needleman,et al.  Temporal trends in the lead concentrations of umbilical cord blood. , 1982, Science.

[30]  J. Burger,et al.  Methodologies for assessing exposure to metals: speciation, bioavailability of metals, and ecological host factors. , 2003, Ecotoxicology and environmental safety.

[31]  J. Burger,et al.  Risk, mercury levels, and birds: relating adverse laboratory effects to field biomonitoring. , 1997, Environmental research.

[32]  G A Fox,et al.  Practical causal inference for ecoepidemiologists. , 1991, Journal of toxicology and environmental health.

[33]  M. Robson.  Methodologies for assessing exposures to metals: human host factors. , 2003, Ecotoxicology and environmental safety.

[34]  Joanna Burger, Michael Gochfeld.  EFFECTS OF LEAD ON BIRDS (LARIDAE): A REVIEW OF LABORATORY AND FIELD STUDIES , 2000, Journal of toxicology and environmental health. Part B, Critical reviews.

[35]  J. Bogden,et al.  Effects of lead exposure before pregnancy and dietary calcium during pregnancy on fetal development and lead accumulation. , 2000, Environmental health perspectives.

[36]  L. Lacerda,et al.  Fish contamination and human exposure to mercury in Tartarugalzinho River, Amapa State, Northern Amazon, Brazil. A screening approach , 1997 .

[37]  D. Bellinger,et al.  Prenatal exposure to toxicants : developmental consequences , 1994 .

[38]  R. Furness,et al.  Using bird feathers to measure mercury in the environment: Relationships between mercury content and moult , 1986 .

[39]  M. Gochfeld,et al.  Factors influencing susceptibility to metals. , 1997, Environmental health perspectives.

[40]  Children.  Pesticides in the Diets of Infants and Children , 1993 .

[41]  J.-G. Park,et al.  Mercury Distribution in Sediments and Bioaccumulation by Fish in Two Oregon Reservoirs: Point-Source and Nonpoint-Source Impacted Systems , 1997, Archives of environmental contamination and toxicology.

[42]  I. Drabæk,et al.  Mercury monitoring: mercury stability in bird feathers , 1984 .

[43]  F. Díaz-Barriga,et al.  Human exposure to metals. Pathways of exposure, biomarkers of effect, and host factors. , 2003, Ecotoxicology and environmental safety.

[44]  J. Hamilton,et al.  Arsenic alters the function of the glucocorticoid receptor as a transcription factor. , 2001, Environmental health perspectives.

[45]  J. Burger,et al.  Lead and neurobehavioral development in gulls: a model for understanding effects in the laboratory and the field. , 1997, Neurotoxicology.

[46]  S. Casteel,et al.  Refining the risk assessment of metal-contaminated soils. , 2001, International journal of hygiene and environmental health.

[47]  B D Beck,et al.  Assessing the contribution from lead in mining wastes to blood lead. , 1990, Regulatory toxicology and pharmacology : RTP.

[48]  Deborah J. Pain,et al.  Lead in the environment , 2003 .

[49]  M. Berglund,et al.  Metal-bone interactions. , 2000, Toxicology letters.

[50]  I. Romieu,et al.  Higher milk intake during pregnancy is associated with lower maternal and umbilical cord lead levels in postpartum women. , 1997, Environmental research.

[51]  D. Peakall.  Physiological Effects of Chlorinated Hydrocarbons on Avian Species , 1975 .

[52]  P. Rodier,et al.  Developing brain as a target of toxicity. , 1995, Environmental health perspectives.

[53]  H. Needleman.  Human Lead Exposure , 1991 .