Optical coherence tomography – current and future applications

Purpose of review Optical coherence tomography (OCT) has revolutionized the clinical practice of ophthalmology. It is a noninvasive imaging technique that provides high-resolution, cross-sectional images of the retina, retinal nerve fiber layer and the optic nerve head. This review discusses the present applications of the commercially available spectral-domain OCT (SD-OCT) systems in the diagnosis and management of retinal diseases, with particular emphasis on choroidal imaging. Future directions of OCT technology and their potential clinical uses are discussed. Recent findings Analysis of the choroidal thickness in healthy eyes and disease states such as age-related macular degeneration, central serous chorioretinopathy, diabetic retinopathy and inherited retinal dystrophies has been successfully achieved using SD-OCT devices with software improvements. Future OCT innovations such as longer-wavelength OCT systems including the swept-source technology, along with Doppler OCT and en-face imaging, may improve the detection of subtle microstructural changes in chorioretinal diseases by improving imaging of the choroid. Summary Advances in OCT technology provide for better understanding of pathogenesis, improved monitoring of progression and assistance in quantifying response to treatment modalities in diseases of the posterior segment of the eye. Further improvements in both hardware and software technologies should further advance the clinician's ability to assess and manage chorioretinal diseases.

[1]  Justis P. Ehlers,et al.  Evaluation of choroidal thickness in retinitis pigmentosa using enhanced depth imaging optical coherence tomography , 2012, British Journal of Ophthalmology.

[2]  Chen D. Lu,et al.  Retinal, anterior segment and full eye imaging using ultrahigh speed swept source OCT with vertical-cavity surface emitting lasers , 2012, Biomedical optics express.

[3]  A. Tsujikawa,et al.  Choroidal thickness after intravitreal ranibizumab injections for choroidal neovascularization , 2012, Clinical ophthalmology.

[4]  J. Duker,et al.  CHOROIDAL IMAGING USING SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY , 2012, Retina.

[5]  Soon-Sun Kwon,et al.  COMPARISON OF CHOROIDAL THICKNESS AMONG PATIENTS WITH HEALTHY EYES, EARLY AGE-RELATED MACULOPATHY, NEOVASCULAR AGE-RELATED MACULAR DEGENERATION, CENTRAL SEROUS CHORIORETINOPATHY, AND POLYPOIDAL CHOROIDAL VASCULOPATHY , 2011, Retina.

[6]  J. Duker,et al.  Analysis of choroidal thickness in age-related macular degeneration using spectral-domain optical coherence tomography. , 2011, American journal of ophthalmology.

[7]  Bernhard Baumann,et al.  Reproducibility of choroidal thickness measurements across three spectral domain optical coherence tomography systems. , 2011, Ophthalmology.

[8]  Boris Hermann,et al.  Mapping choroidal and retinal thickness variation in type 2 diabetes using three-dimensional 1060-nm optical coherence tomography. , 2011, Investigative ophthalmology & visual science.

[9]  Yoshiaki Yasuno,et al.  Reproducibility of retinal and choroidal thickness measurements in enhanced depth imaging and high-penetration optical coherence tomography. , 2011, Investigative ophthalmology & visual science.

[10]  Y. Ikuno,et al.  Transient Choroidal Thinning after Intravitreal Bevacizumab Injection for Myopic Choroidal Neovascularization , 2011 .

[11]  P. Finger,et al.  Spectral domain-optical coherence tomography analysis of choroidal osteoma , 2011, British Journal of Ophthalmology.

[12]  James G Fujimoto,et al.  CHOROIDAL THICKNESS IN PATIENTS WITH DIABETIC RETINOPATHY ANALYZED BY SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY , 2011, Retina.

[13]  M. Larsen,et al.  Choroidal thickness following extrafoveal photodynamic treatment with verteporfin in patients with central serous chorioretinopathy , 2011, Acta ophthalmologica.

[14]  J. Duker,et al.  The Effect of Intravitreal Anti-VEGF Therapy on Choroidal Thickness in Wet AMD using Spectral Domain Optical Coherence Tomography , 2011 .

[15]  Peter K Kaiser,et al.  Optical coherence tomography enhanced depth imaging of choroidal tumors. , 2011, American journal of ophthalmology.

[16]  Y. Yasuno,et al.  Three-dimensional visualization of ocular vascular pathology by optical coherence angiography in vivo. , 2011, Investigative ophthalmology & visual science.

[17]  Joel S Schuman,et al.  Documentation of intraretinal retinal pigment epithelium migration via high-speed ultrahigh-resolution optical coherence tomography. , 2010, Ophthalmology.

[18]  A. Lotery,et al.  Central serous chorioretinopathy: an update on pathogenesis and treatment , 2010, Eye.

[19]  J. Duker,et al.  Cirrus HD-OCT high definition imaging is another tool available for visualization of the choroid and provides agreement with the finding that the choroidal thickness is increased in central serous chorioretinopathy in comparison to normal eyes. , 2010, Retina.

[20]  R. Spaide,et al.  Subfoveal choroidal thickness after treatment of central serous chorioretinopathy. , 2010, Ophthalmology.

[21]  James G Fujimoto,et al.  Choroidal thickness in normal eyes measured using Cirrus HD optical coherence tomography. , 2010, American journal of ophthalmology.

[22]  R. Kawasaki,et al.  Subfoveal choroidal thickness in typical age-related macular degeneration and polypoidal choroidal vasculopathy , 2010, Graefe's Archive for Clinical and Experimental Ophthalmology.

[23]  Adnan Tufail,et al.  Choroidal imaging in inherited retinal disease using the technique of enhanced depth imaging optical coherence tomography , 2010, Graefe's Archive for Clinical and Experimental Ophthalmology.

[24]  G. Holló,et al.  Reproducibility of retinal nerve fiber layer and macular thickness measurement with the RTVue-100 optical coherence tomograph. , 2010, Ophthalmology.

[25]  J. Duker,et al.  COMPARISON OF SPECTRAL/FOURIER DOMAIN OPTICAL COHERENCE TOMOGRAPHY INSTRUMENTS FOR ASSESSMENT OF NORMAL MACULAR THICKNESS , 2010, Retina.

[26]  C. Costagliola,et al.  Enhanced depth imaging spectral-domain optical coherence tomography. , 2010, Retina.

[27]  R. Spaide,et al.  ENHANCED DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHY OF THE CHOROID IN CENTRAL SEROUS CHORIORETINOPATHY , 2009, Retina.

[28]  E. Campos,et al.  Subfoveal choroidal blood flow and central retinal function in retinitis pigmentosa. , 2009, Investigative ophthalmology & visual science.

[29]  Richard F Spaide,et al.  Age-related choroidal atrophy. , 2009, American journal of ophthalmology.

[30]  R. Spaide,et al.  Enhanced Depth Imaging Optical Coherence Tomography of the Choroid in Normal Eyes , 2009 .

[31]  J. Izatt,et al.  Measurement of total blood flow in the normal human retina using Doppler Fourier-domain optical coherence tomography , 2009, British Journal of Ophthalmology.

[32]  Iwona Gorczynska,et al.  Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head. , 2008, Investigative ophthalmology & visual science.

[33]  Wolfgang Drexler,et al.  State-of-the-art retinal optical coherence tomography , 2008, Progress in Retinal and Eye Research.

[34]  C. Regillo,et al.  Anti-VEGF agents in the treatment of neovascular age-related macular degeneration: applying clinical trial results to the treatment of everyday patients. , 2007, American journal of ophthalmology.

[35]  Alan Diego Negretto,et al.  Emprego das medidas anatômicas do buraco macular idiopático obtidas pela tomografia de coerência óptica como fator preditivo nos resultados visuais: um estudo piloto , 2007 .

[36]  J. Fujimoto,et al.  Fourier domain mode locking at 1050 nm for ultra-high-speed optical coherence tomography of the human retina at 236,000 axial scans per second. , 2007, Optics letters.

[37]  W. Drexler,et al.  Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients. , 2007, Journal of biomedical optics.

[38]  Masanori Hangai,et al.  Measurement of Retinal Nerve Fiber Layer Thickness and Macular Volume for Glaucoma Detection Using Optical Coherence Tomography , 2007, Japanese Journal of Ophthalmology.

[39]  H. Sachs,et al.  Retreatment of full-thickness macular hole: predictive value of optical coherence tomography , 2007, British Journal of Ophthalmology.

[40]  I. Gorczynska,et al.  High-speed, high-resolution optical coherence tomography retinal imaging with a frequency-swept laser at 850 nm. , 2007, Optics letters.

[41]  Wolfgang Drexler,et al.  Ultra-high resolution optical coherence tomography assessment of photoreceptors in retinitis pigmentosa and related diseases. , 2006, American journal of ophthalmology.

[42]  J. Izatt,et al.  Swept source optical coherence tomography using an all-fiber 1300-nm ring laser source. , 2005, Journal of biomedical optics.

[43]  W. Drexler,et al.  In vivo retinal optical coherence tomography at 1040 nm - enhanced penetration into the choroid. , 2005, Optics express.

[44]  Ali Erginay,et al.  Diagnosis of macular pseudoholes and lamellar macular holes by optical coherence tomography. , 2004, American journal of ophthalmology.

[45]  Shigeki Fujii,et al.  Prediction of postoperative visual outcome based on hole configuration by optical coherence tomography in eyes with idiopathic macular holes. , 2004, American journal of ophthalmology.

[46]  C. Puliafito,et al.  Clinical applications of optical coherence tomography for the diagnosis and management of macular diseases. , 2004, Ophthalmology clinics of North America.

[47]  Maciej Wojtkowski,et al.  Real-time measurement of in vitro flow by Fourier-domain color Doppler optical coherence tomography. , 2004, Optics letters.

[48]  Teresa C. Chen,et al.  In vivo dynamic human retinal blood flow imaging using ultra-high-speed spectral domain optical Doppler tomography , 2003 .

[49]  R. Zawadzki,et al.  Real-time assessment of retinal blood flow with ultrafast acquisition by color Doppler Fourier domain optical coherence tomography. , 2003, Optics express.

[50]  Changhuei Yang,et al.  Instantaneous quadrature low coherence interferometry with 3 x 3 fiber optic couplers , 2003, Conference on Lasers and Electro-Optics, 2003. CLEO '03..

[51]  B. Bouma,et al.  Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography. , 2003, Optics letters.

[52]  A. Fercher,et al.  Enhanced visualization of choroidal vessels using ultrahigh resolution ophthalmic OCT at 1050 nm. , 2003, Optics express.

[53]  A. Fercher,et al.  Performance of fourier domain vs. time domain optical coherence tomography. , 2003, Optics express.

[54]  T. Matsuo,et al.  Risk factors for diabetic choroidopathy in patients with diabetic retinopathy , 2002, Graefe's Archive for Clinical and Experimental Ophthalmology.

[55]  J. Izatt,et al.  In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography. , 1997, Optics letters.

[56]  Thomas E. Milner,et al.  Two-dimensional birefringence imaging in biological tissue using polarization-sensitive optical coherence tomography , 1997, European Conference on Biomedical Optics.

[57]  J. Fujimoto,et al.  Optical coherence tomography using a frequency-tunable optical source. , 1997, Optics letters.

[58]  L. Laatikainen,et al.  Diabetic retinopathy in people aged 70 years or older. The Oulu Eye Study , 1997, The British journal of ophthalmology.

[59]  D. S. Mcleod,et al.  Intrachoroidal microvascular abnormality: a previously unrecognized form of choroidal neovascularization. , 1996, American journal of ophthalmology.

[60]  R N Weinreb,et al.  Confocal scanning infrared laser ophthalmoscopy for indocyanine green angiography. , 1995, American journal of ophthalmology.

[61]  R. Klein,et al.  Prevalence of age-related maculopathy. The Beaver Dam Eye Study. , 1992, Ophthalmology.

[62]  B. S. Fine,et al.  Diabetic choroidopathy. Light and electron microscopic observations of seven cases. , 1985, Ophthalmology.

[63]  Ahmad A. Alwassia,et al.  De novo appearance of a choroidal osteoma in an eye with previous branch retinal vein occlusion. , 2013, Ophthalmic surgery, lasers & imaging retina.

[64]  Y. Nakashima,et al.  [Use of anatomical measures of idiopathic macular hole obtained through optical coherence tomography as a predictive factor in visual results: a pilot study]. , 2007, Arquivos brasileiros de oftalmologia.

[65]  William J Feuer,et al.  An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration. , 2007, American journal of ophthalmology.

[66]  K. Shiraki,et al.  Age-related scattered hypofluorescent spots on late-phase indocyanine green angiograms , 2004, International Ophthalmology.

[67]  Barry Cense,et al.  In vivo dynamic human retinal blood flow imaging using ultra-high-speed spectral domain optical coherence tomography. , 2003, Optics express.

[68]  G. Ripandelli,et al.  Optical coherence tomography. , 1998, Seminars in ophthalmology.