Dissociative Anesthesia: Further Pharmacologic Studies and First Clinical Experience with the Phencyclidine Derivative Cl‐581

HERE IS A definite need for safe and T potent intravenously administered anesthetics of short duration which combine analgesic and sleep-producing effects without significant cardiovascular and respiratory depression. Recently, a number of compounds related to phenylcyclohexylamine have aroused clinical interest because they appear to approach such requirements. Phencyclidine hydrochloride was the prototype of this group of agents. After preliminary laboratory studies1 its clinical usefulness as an anesthetic was investigated by Greifenstein and associates.2