Effect of Gd substitution on the crystal structure, magnetic susceptibility and biocompatibility of nano-sized Ca10-x Gd x (PO4)6(OH)2 particles

This research investigated the crystal structure, magnetic susceptibility, and biocompatibility of the nano-sized Ca10-x Gd x (PO4)6(OH)2 particles for x = 0%, 1.00%, 1.25%, 1.50%, and 1.75%. The hydrolysis method was employed to produce the nano-sized Ca10-x Gd x (PO4)6(OH)2 particles from natural calcite. The crystal structure and magnetic susceptibility of the nano-sized Ca10-x Gd x (PO4)6(OH)2 particles were characterized by means of X-ray diffraction (XRD) and susceptibility meter, respectively. The elemental data analysis presented that the natural calcite as the main precursor contained calcium of 98.84%. Moreover, the diffraction data showed that the increase in Gd content decreased the lattice parameters and crystal volume of the nano-sized Ca10-x Gd x (PO4)6(OH)2 particles. The magnetic character of the nano-sized Ca10-x Gd x (PO4)6(OH)2 particles changed from diamagnetic to paramagnetic as the increase of Gd content. Interestingly, the increasing Gd content enhanced the magnetic susceptibility of the nano-sized Ca10-x Gd x (PO4)6(OH)2 particles. Furthermore, the nano-sized Ca10-x Gd x (PO4)6(OH)2 particles had an excellent biocompatibility. Therefore, the prepared nano-sized Ca10-x Gd x (PO4)6(OH)2 particles open a potency to be applied for biomedical treatment.

[1]  Wei Yang,et al.  Hierarchically Porous Hydroxyapatite Hybrid Scaffold Incorporated with Reduced Graphene Oxide for Rapid Bone Ingrowth and Repair. , 2019, ACS nano.

[2]  Jiping Cheng,et al.  Effect of TiO2 doping on densification and mechanical properties of hydroxyapatite by microwave sintering , 2019, Ceramics International.

[3]  Sunaryono,et al.  Study on Structural Characters of Nano-sized Hydroxyapatite Prepared from Limestone , 2019, IOP Conference Series: Materials Science and Engineering.

[4]  S. Mondal,et al.  Comparative characterization of biogenic and chemical synthesized hydroxyapatite biomaterials for potential biomedical application , 2019, Materials Chemistry and Physics.

[5]  Pengfei Li,et al.  A strong, tough, and osteoconductive hydroxyapatite mineralized polyacrylamide/dextran hydrogel for bone tissue regeneration. , 2019, Acta biomaterialia.

[6]  Tahsin Tecelli Öpöz,et al.  Ti6Al4V Surface Modification by Hydroxyapatite Powder Mixed Electrical Discharge Machining for Medical Application , 2019, International Journal of Advances in Engineering and Pure Sciences.

[7]  Margarete T. G. de Almeida,et al.  One-Pot Synthesis and Antifungal Activity of Nontoxic Silver-Loaded Hydroxyapatite Nanocomposites against Candida Species , 2019, ACS Applied Nano Materials.

[8]  R. Jain,et al.  Biomimetic Hydroxyapatite a Potential Universal Nanocarrier for Cellular Internalization & Drug Delivery , 2019, Pharmaceutical Research.

[9]  S. Ramakrishna,et al.  Ramification of zinc oxide doped hydroxyapatite biocomposites for the mineralization of osteoblasts. , 2019, Materials science & engineering. C, Materials for biological applications.

[10]  Kezheng Chen,et al.  Novel fluoridated hydroxyapatite/MAO composite coating on AZ31B magnesium alloy for biomedical application , 2019, Applied Surface Science.

[11]  J. Lopes,et al.  New insights into nanohydroxyapatite/chitosan nanocomposites for bone tissue regeneration , 2019, Materials for Biomedical Engineering.

[12]  David McCoul,et al.  Self-Assembled Hydroxyapatite-Graphene Scaffold for Photothermal Cancer Therapy and Bone Regeneration. , 2018, Journal of biomedical nanotechnology.

[13]  S. Safi,et al.  Mesoporous and hollow hydroxyapatite nanostructured particles as a drug delivery vehicle for the local release of ibuprofen. , 2018, Materials science & engineering. C, Materials for biological applications.

[14]  K. Pickering,et al.  A Review on the Use of Hydroxyapatite-Carbonaceous Structure Composites in Bone Replacement Materials for Strengthening Purposes , 2018, Materials.

[15]  Sudip Mondal,et al.  Recent progress on fabrication and drug delivery applications of nanostructured hydroxyapatite. , 2018, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[16]  Le Yu,et al.  Magnetic properties and cytocompatibility of transition-metal-incorporated hydroxyapatite. , 2018, Materials science & engineering. C, Materials for biological applications.

[17]  Jianjun Du,et al.  Biodegradable Drug-Loaded Hydroxyapatite Nanotherapeutic Agent for Targeted Drug Release in Tumors. , 2018, ACS applied materials & interfaces.

[18]  Li Zhang,et al.  Dual signal amplification strategy for amperometric aptasensing using hydroxyapatite nanoparticles. Application to the sensitive detection of the cancer biomarker platelet-derived growth factor BB , 2017, Microchimica Acta.

[19]  M. Usta,et al.  Bioactivity and biocompatibility of hydroxyapatite-based bioceramic coatings on zirconium by plasma electrolytic oxidation. , 2017, Materials science & engineering. C, Materials for biological applications.

[20]  Matthias Epple,et al.  Synthesis of nanosized hydroxyapatite/agarose powders for bone filler and drug delivery application , 2016 .

[21]  M. Ferraris,et al.  Synthesis of magnetic hydroxyapatite by hydrothermal–microwave technique: Dielectric, protein adsorption, blood compatibility and drug release studies , 2015 .

[22]  D. Vashaee,et al.  In situ preparation of iron oxide nanoparticles in natural hydroxyapatite/chitosan matrix for bone tissue engineering application , 2015 .

[23]  K. Madhumathi,et al.  Silver and Gadolinium Ions Co-substituted Hydroxyapatite Nanoparticles as Bimodal Contrast Agent for Medical Imaging , 2014 .

[24]  Marcel Warntjes,et al.  Gd2O3 nanoparticles in hematopoietic cells for MRI contrast enhancement , 2011, International Journal of Nanomedicine.

[25]  Jin Wu,et al.  The photoluminescence, drug delivery and imaging properties of multifunctional Eu3+/Gd3+ dual-doped hydroxyapatite nanorods. , 2011, Biomaterials.

[26]  S. Nair,et al.  A molecular receptor targeted, hydroxyapatite nanocrystal based multi-modal contrast agent. , 2010, Biomaterials.