Pilot feasibility study of in vivo intraoperative quantitative optical coherence tomography of human brain tissue during glioma resection

Abstract This study investigates the feasibility of in vivo quantitative optical coherence tomography (OCT) of human brain tissue during glioma resection surgery in six patients. High‐resolution detection of glioma tissue may allow precise and thorough tumor resection while preserving functional brain areas, and improving overall survival. In this study, in vivo 3D OCT datasets were collected during standard surgical procedure, before and after partial resection of the tumor, both from glioma tissue and normal parenchyma. Subsequently, the attenuation coefficient was extracted from the OCT datasets using an automated and validated algorithm. The cortical measurements yield a mean attenuation coefficient of 3.8 ± 1.2 mm−1 for normal brain tissue and 3.6 ± 1.1 mm−1 for glioma tissue. The subcortical measurements yield a mean attenuation coefficient of 5.7 ± 2.1 and 4.5 ± 1.6 mm−1 for, respectively, normal brain tissue and glioma. Although the results are inconclusive with respect to trends in attenuation coefficient between normal and glioma tissue due to the small sample size, the results are in the range of previously reported values. Therefore, we conclude that the proposed method for quantitative in vivo OCT of human brain tissue is feasible during glioma resection surgery.

[1]  Theo J M Ruers,et al.  Optical coherence tomography in vulvar intraepithelial neoplasia , 2012, Journal of biomedical optics.

[2]  A. Welch,et al.  A review of the optical properties of biological tissues , 1990 .

[3]  Mitchel S Berger,et al.  An extent of resection threshold for newly diagnosed glioblastomas. , 2011, Journal of neurosurgery.

[4]  Dirk J. Faber,et al.  Measurement of the axial point spread function in scattering media using single-mode fiber-based optical coherence tomography , 2003 .

[5]  S. Yun,et al.  In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve. , 2004, Optics express.

[6]  E. McVeigh,et al.  Detection of human brain cancer infiltration ex vivo and in vivo using quantitative optical coherence tomography , 2015, Science Translational Medicine.

[7]  David D Sampson,et al.  Correlation of static speckle with sample properties in optical coherence tomography. , 2006, Optics letters.

[8]  I. Vitkin,et al.  Texture analysis of optical coherence tomography speckle for characterizing biological tissues in vivo. , 2013, Optics letters.

[9]  O. Carrasco-Zevallos,et al.  Review of intraoperative optical coherence tomography: technology and applications [Invited]. , 2017, Biomedical optics express.

[10]  Ivan Popov,et al.  K‐distribution three‐dimensional mapping of biological tissues in optical coherence tomography , 2018, Journal of biophotonics.

[11]  Angelika Unterhuber,et al.  Imaging ex vivo healthy and pathological human brain tissue with ultra-high-resolution optical coherence tomography. , 2005, Journal of biomedical optics.

[12]  David A Boas,et al.  Characterizing the optical properties of human brain tissue with high numerical aperture optical coherence tomography. , 2017, Biomedical optics express.

[13]  T. V. van Leeuwen,et al.  OCT Amplitude and Speckle Statistics of Discrete Random Media , 2017, Scientific Reports.

[14]  Simon D. Strackee,et al.  Feasibility of Optical Coherence Tomography (OCT) for Intra-Operative Detection of Blood Flow during Gastric Tube Reconstruction , 2018, Sensors.

[15]  R. Agid,et al.  Preoperative Grading of Presumptive Low-Grade Astrocytomas on MR Imaging: Diagnostic Value of Minimum Apparent Diffusion Coefficient , 2008, American Journal of Neuroradiology.

[16]  Dirk Faber,et al.  Parametric imaging of attenuation by optical coherence tomography: review of models, methods, and clinical translation , 2020, Journal of biomedical optics.

[17]  D. Sampson,et al.  Parametric imaging of cancer with optical coherence tomography. , 2010, Journal of biomedical optics.

[18]  Dirk J. Faber,et al.  Validation of quantitative attenuation and backscattering coefficient measurements by optical coherence tomography in the concentration-dependent and multiple scattering regime , 2015, Journal of biomedical optics.

[19]  Jia Xu,et al.  MicroRNA-346 inhibits the growth of glioma by directly targeting NFIB , 2019, Cancer Cell International.

[20]  Susan M. Chang,et al.  Role of extent of resection in the long-term outcome of low-grade hemispheric gliomas. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[21]  D. D. de Bruin,et al.  Optical phantoms of varying geometry based on thin building blocks with controlled optical properties. , 2010, Journal of biomedical optics.

[22]  D. D. de Bruin,et al.  Quantitative attenuation analysis for identification of early Barrett's neoplasia in volumetric laser endomicroscopy. , 2017, Journal of biomedical optics.

[23]  Ton G van Leeuwen,et al.  Quantitative measurement of attenuation coefficients of bladder biopsies using optical coherence tomography for grading urothelial carcinoma of the bladder. , 2010, Journal of biomedical optics.

[24]  T. G. van Leeuwen,et al.  Quantitative comparison of the OCT imaging depth at 1300 nm and 1600 nm , 2010, Biomedical optics express.

[25]  D. Sampson,et al.  Parametric imaging of the local attenuation coefficient in human axillary lymph nodes assessed using optical coherence tomography , 2012, Biomedical optics express.

[26]  G. Pazour,et al.  Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness , 2017, Scientific Reports.

[27]  B. Devaux,et al.  Imaging of non-tumorous and tumorous human brain tissues with full-field optical coherence tomography☆ , 2013, NeuroImage: Clinical.

[28]  S. Koekkoek,et al.  Functional Ultrasound (fUS) During Awake Brain Surgery: The Clinical Potential of Intra-Operative Functional and Vascular Brain Mapping , 2020, Frontiers in Neuroscience.

[29]  A. Giese,et al.  Time‐domain and spectral‐domain optical coherence tomography in the analysis of brain tumor tissue , 2006, Lasers in surgery and medicine.